A comparative study of hematological parameters between hypertensive and normotensive individuals in Harar, eastern Ethiopia

Sileshi, Beza; Urgessa, Fekadu; Wordofa, Moges

doi:10.1371/journal.pone.0260751

Cited by 9 publications

(12 citation statements)

References 32 publications

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“…Platelet count was significantly lower in a preeclamptic group compared to that in a control group, whereas MPV and PDW were significantly higher in women with preeclampsia [ 48 ]. Platelet count had a significant but negative correlation with the duration of hypertension illness, while MPV showed a positive and significant correlation [ 49 ]. Increased platelet activation, and the subsequent occurrence of placental fibrinoid deposition, are linked to placenta pathologies such as preeclampsia [ 50 ].…”

Section: Discussionmentioning

confidence: 99%

A Critical Analysis of the Automated Hematology Assessment in Pregnant Women at Low and at High Altitude: Association between Red Blood Cells, Platelet Parameters, and Iron Status

Figueroa-Mujica

Ccahuantico

Ccorahua-Ríos

et al. 2022

Life

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The objectives of the study were to determine differences in the parameters of red blood cells (RBC), white blood cells (WBC), and platelets at low altitude (LA) and at high altitude (HA) and with the gestation being advanced, and to determine correlations between parameters of RBC and platelets. We also studied the association of RBC and platelets with markers of iron status. In addition, markers of iron status and inflammation were measured and compared at each trimester of gestation in pregnant women at LA and HA. A cross-sectional comparative study was conducted at Lima (150 m above sea level) and Cusco at 3400 m above sea level from May to December 2019. Hematological parameters in pregnant women (233 at LA and 211 at HA) were analyzed using an automated hematology analyzer. Serum ferritin levels, soluble transferrin receptor (sTfR), hepcidin, erythropoietin, testosterone, estradiol, and interleukin-6 (IL6) levels were measured by ELISA. One-way ANOVA supplemented with post hoc test, chi-square test, and Pearson correlation test statistical analyses were performed. p < 0.05 was considered significant. Pregnant woman at HA compared to LA had significantly lower WBC (p < 0.01), associated with higher parameters of the RBC, except for the mean corpuscular volume (MCV) that was no different (p > 0.05). Platelets and mean platelet volume (MPV) were higher (p < 0.01), and platelet distribution width (PDW) was lower at HA than at LA (p < 0.01). A higher value of serum ferritin (p < 0.01), testosterone (p < 0.05), and hepcidin (p < 0.01) was observed at HA, while the concentration of sTfR was lower at HA than at LA (p < 0.01). At LA, neutrophils increased in the third trimester (p < 0.05). RBC parameters decreased with the progress of the gestation, except RDW-CV, which increased. The platelet count decreased and the MPV and PDW were significantly higher in the third trimester. Serum ferritin, hepcidin, and serum testosterone decreased, while sTfR and serum estradiol increased during gestation. At HA, the WBC and red blood cell distribution width- coefficient of variation (RDW-CV), PCT, and serum IL-6 did not change with gestational trimesters. RBC, hemoglobin (Hb), hematocrit (Hct), mean corpuscular hemoglobin concentration (MCHC), and platelet count were lower as gestation advanced. MCV, MPV, and PDW increased in the third trimester. Serum ferritin, testosterone, and hepcidin were lower in the third trimester. Serum estradiol, erythropoietin, and sTfR increased as gestation progressed. Direct or inverse correlations were observed between RBC and platelet parameters and LA and HA. A better number of significant correlations were observed at HA. Hb, Hct, and RDW-CV showed a significant correlation with serum ferritin at LA and HA. Of these parameters, RDW-CV and PDW showed an inversely significant association with ferritin (p < 0.05). In conclusion, a different pattern was observed in hematological markers as well as in iron status markers between pregnant women at LA and HA. In pregnant women a significant correlation between several RBC parameters with platelet marker parameters was also observed. Data suggest that pregnant women at HA have adequate iron status during pregnancy as reflected by higher serum ferritin levels, lower sTfR levels, and higher hepcidin values than pregnant women at LA.

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Section: Discussionmentioning

confidence: 99%

A Critical Analysis of the Automated Hematology Assessment in Pregnant Women at Low and at High Altitude: Association between Red Blood Cells, Platelet Parameters, and Iron Status

Figueroa-Mujica

Ccahuantico

Ccorahua-Ríos

et al. 2022

Life

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“…In a retrospective cohort study, Gang et al found an increased MPV related to an increase in the incidence of hypertension [ 14 ]. In a study by Sileshi et al examining hematological parameters in hypertensive and normotensive individuals, an MPV of 9.5 ± 2.22 fL was found in hypertensive persons and an MPV 9.04 ± 1.06 fL in normotensive individuals; the difference was statistically significant ( p = 0.024) [ 15 ]. Akın et al found an MPV of 9.3 ± 1.4 fL in persons with resistant hypertension, an MPV of 8.8 ± 0.8 fL in patients with controlled hypertension, and an MPV of 8.5 ± 0.8 fL in normotensive individuals.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Mean Platelet Volume in Children with Hypertension

Yildiz,

Kizilca

2023

International Journal of Hypertension

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Background. Childhood hypertension, a disease with increasing prevalence, can lead to severe health problems. With the increased pressure on the vascular endothelium in hypertension, lesions in the endothelium result in endothelial activation and a process of inflammation, which causes platelet activation and in the bone marrow the release of platelet precursor cells into the peripheral blood stream. During inflammation, changes in the number and size of platelets are observed. With the release of platelet precursors into the peripheral blood stream due to platelet activation, an increase in mean platelet volume (MPV) is also seen. Aim. Our aim in this study is the evaluation of MPV changes in the hemogram of children suffering from hypertension, a condition causing severe cardiovascular problems. Material and Methods. This research is a descriptive retrospective cross-sectional study. It consists of a patient group diagnosed with hypertension and a control group of children presenting for routine check-ups with no diagnosed hypertension. Demographic characteristics, arterial pressure values, and hemogram parameters have been evaluated. Results. A total of 90 cases were enrolled in the study, including a patient group of 45 cases with hypertension (19 females, 26 males) and a control group of 45 cases (27 females, 18 males). The median age was 15 years in the hypertension group and 13 years in the control group. In the hypertension cases, the thickness of the carotis intima media was statistically significantly greater than in the control group ( p < 0.001). Echocardiographic findings (IVSd, LVDd, LVPWd, IVSs, LVDs, LVPWs, and LV mass) were significantly higher in the hypertension group compared to the control group ( p < 0.001). A statistically significant difference in platelet count and MPV values between the groups was not found ( p = 0.151, p = 0.405, respectively). Conclusion. While MPV is hypothesized to be higher in hypertensive individuals, there was no statistically significant difference between the hypertensive and non-hypertensive groups in this study.

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“…RDW-CV is usually written as RDW. Recent literature has shown that among the CBC parameters, elevated RDW is a novel biomarker used to predict the incidences and prognoses of many diseases, including hypertension [ 8 ], diabetes [ 9 ], acute ischemic stroke [ 10 ], and cardiovascular diseases [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

“…A recent study in Ethiopia revealed a higher median RDW in hypertensive patients than in apparently healthy individuals [ 8 ]. Early diagnosis and prompt intervention are highly important to reduce the risks of hypertension and its complications (morbidity and mortality).…”

Section: Introductionmentioning

confidence: 99%

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The association between red cell distribution width and newly diagnosed hypertension among adults in Northern Sudan: a case-control study

Hassan,

Musa,

Omer

et al. 2023

Libyan Journal of Medicine

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The existing data have shown inconsistency about the association between red cell distribution width (RDW) and hypertension. Thus, the aim of the present study was to investigate the association between RDW and newly diagnosed hypertension among adults in Sudan. This was a case-control study conducted in Northern Sudan from July to September 2022. The cases were patients with newly diagnosed hypertension ( n = 78), and the controls were healthy participants ( n = 78). A questionnaire was used to collect the participants’ sociodemographic, and clinical data. RDW was measured using an automated hematology analyzer. A logistic regression analysis was performed. The univariate analysis revealed no association between sex, educational level, occupational level, RDW, and newly diagnosed hypertension. In the multivariate analysis, increasing age (adjusted odds ratio [AOR], 1.05; 95% confidence interval [CI], 1.02‒1.08) and body mass index (AOR, 1.12; 95% CI, 1.05‒1.19) were associated with newly diagnosed hypertension. No association was found between RDW and newly diagnosed hypertension. No correlation was found between RDW and systolic ( r = 0.045, P = 0.577) or diastolic blood pressure ( r = 0.023, P = 0.772). In conclusion, no association in RDW was found between the patients with newly diagnosed hypertension and the healthy controls.

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A comparative study of hematological parameters between hypertensive and normotensive individuals in Harar, eastern Ethiopia

Cited by 9 publications

References 32 publications

A Critical Analysis of the Automated Hematology Assessment in Pregnant Women at Low and at High Altitude: Association between Red Blood Cells, Platelet Parameters, and Iron Status

A Critical Analysis of the Automated Hematology Assessment in Pregnant Women at Low and at High Altitude: Association between Red Blood Cells, Platelet Parameters, and Iron Status

Evaluation of Mean Platelet Volume in Children with Hypertension

The association between red cell distribution width and newly diagnosed hypertension among adults in Northern Sudan: a case-control study

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