A comparative clinical trial of the efficacy of two different aqueous solutions of cyclosporine for the treatment of moderate-to-severe dry eye syndrome

Abstract

Cyclosporine A reduced complaints and improved major ocular signs in patients with moderate-to-severe dry eye disease. The group treated with the 0.1% cyclosporine A aqueous solution outperformed the other groups.

Use of mini scleral contact lenses in moderate to severe dry eye

“…These include topical cyclosporine A in different concentrations (0.05 [12][13][14] or 0.1%) [15] and frequencies [16], plasma rich in growth factors (PRGF) [17], combined 0.05% cyclosporine and 1% methylprednisolone [18], CF101 [19], resolvin E1 [20], fatty acid and androgen supplementation and oral antibiotics [21], and ocular iontophoresis of EGP-437 [22]. Besides medical treatments, different surgical interventions from punctual occlusion either with plugs [23,24] or surgical methods [25], to more extensive ocular surface surgeries such as amniotic membrane transplantation [26] or labial salivary gland transplantation [27][28][29] have been proposed for management of refractory cases of dry eye and other new methods such as reduced submandibular glands [30] or thermodynamic treatments [31] also seem promising.…”

Systematic review of randomised clinical trials on topical ciclosporin A for the treatment of dry eye disease

“…A total of 3 studies evaluated CsA at different concentrations: Baiza-Duran et al evaluated 0.05% and 0.1% CsA in aqueous solution as compared to vehicle in 183 patients for 14 weeks, Sall et al compared 2 concentrations (0.05% and 0.1%) of a CsA ophthalmic emulsion versus vehicle in 877 patients for 6 months and Stevenson et al evaluated 4 different concentrations (0.05%, 0.1%, 0.2% and 0.4%) of a ciclosporin A oil-in-water formulation versus vehicle for 3 months in 162 patients 10 11 18…”

“…All reported a significant amelioration of at least one ocular symptom with CsA eyedrop treatment8 10 11 13 15 16 18 19 24 (see online supplementary table). However, in seven of these trials, CsA treatment induced no amelioration of at least one symptom 8 10 11 13 16 18 19.…”

“…All reported a significant amelioration of at least one ocular symptom with CsA eyedrop treatment8 10 11 13 15 16 18 19 24 (see online supplementary table). However, in seven of these trials, CsA treatment induced no amelioration of at least one symptom 8 10 11 13 16 18 19. Specifically, burning/stinging, foreign body sensation and photophobia were evaluated in six RCTs showing no improvement in 100%, 50% and 83%, respectively 8 10 11 13 16 18 19.…”

Supercritical fluid-mediated liposomes containing cyclosporin A for the treatment of dry eye syndrome in a rabbit model: comparative study with the conventional cyclosporin A emulsion

“…3 The use of topical steroids has been shown to produce relief from dry eye symptoms, but longterm use results in potential side effects such as glaucoma and cataract. 4 Therefore, the development of agents is essential for chronic use of the drug without serious adverse effects.…”