A comparative bioavailability study of three conventional eye drops versus a single lyophilisate

Lux, Anja; Maier, Stephan E.; Dinslage, Sven; Süverkrüp, Richard; Diestelhorst, Michael

doi:10.1136/bjo.87.4.436

Cited by 41 publications

(13 citation statements)

References 12 publications

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“…Topical delivery of ophthalmic preparations can be advantageous by delivering high drug concentrations directly to the ocular surface, yet challenges remain with this delivery system. Most notably, rapid clearance through the nasolacrimal duct, dilution through the production of reflex tearing, and protein binding are all concerns with topical ophthalmic delivery of antibiotic medications 14,15. Furthermore, the azithromycin molecule is extremely lipophilic, making a stable aqueous formulation of the drug historically difficult to manufacture.…”

Section: Introductionmentioning

confidence: 99%

Azithromycin in DuraSite® for the treatment of blepharitis

Luchs¹

2010

OPTH

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Blepharitis is a common inflammatory disease of the eyelid. Posterior blepharitis affects the posterior lamella of the eyelid and involves inflammation of the meibomian glands, whereas anterior blepharitis affects the anterior lamella of the eyelid and the eyelashes; either version can be inflammatory or infectious in nature. Each of these conditions can incite or propagate the other; anterior blepharitis, if not treated, can lead to meibomian gland disease, and vice versa. Blepharitis is typically chronic, and can be associated with a variety of systemic diseases such as dermatitis, as well as ocular diseases such as dry eye, conjunctivitis, or keratitis. The standard treatment regimen historically consists of lid hygiene with warm compresses and eyelid scrubs, although these treatment modalities may have limited efficacy for many patients, especially those with more severe disease. Adjunctive treatment includes systemic and topical antibiotics, topical corticosteroids, and tear replacement therapy. Topical antibiotics are recommended to decrease the bacterial load, and topical corticosteroids may help in cases of severe inflammation. Azithromycin ophthalmic solution 1% in DuraSite® (AzaSite®; Inspire Pharmaceuticals, Durham, North Carolina, USA) has been proposed as a novel treatment for posterior blepharitis, based on its well-known anti-infective profile, its anti-inflammatory properties, its excellent tissue penetration, and its regulatory approval for the treatment of bacterial conjunctivitis. This review focuses on an off-label indication for topical azithromycin 1% in DuraSite for the treatment of blepharitis.

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Section: Introductionmentioning

confidence: 99%

Azithromycin in DuraSite® for the treatment of blepharitis

Luchs¹

2010

OPTH

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“…Their data have shown significantly higher bioavailability of fluorescein in both the cornea and the mid anterior chamber up to 7 hours in the eyes treated with lyophilisate. 16 Our intention was to examine the first 30 minutes after application in part A and the long term bioavailability up to 12 hours after application of lyophilisate compared with conventional eye drops in part B. During the first 30 minutes after application, the corneal stroma (C) mean fluorescein concentrations in eyes treated with lyophilisates were 46 higher after 2 minutes, 166 higher after 14 minutes, and 56 higher after 30 minutes (Table 1).…”

Section: Discussionmentioning

confidence: 99%

Bioavailability of fluorescein from a new drug delivery system in human eyes

Steinfeld

2004

British Journal of Ophthalmology

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“…[20][21][22][23][24][25][26] It consists of a freeze-dried drop containing the drug and bulk forming water-soluble or swelling excipients (polymers). The main difference between this preparation and our freeze-dried preparation is that different polymers are used and our preparation has a much smaller proportion of polymers per dose.…”

Section: Other Experiments With Powdermentioning

confidence: 99%