A Comparative Assessment of Biological Effects and Chemical Profile of Italian Asphodeline lutea Extracts

Abstract

The present study aims to highlight the therapeutic potential of Asphodeline lutea (AL), a wild edible plant of the Mediterranean diet. Roots, aerial parts, and flowers of AL at two different phenological stages were collected from three locations in Italy. The inhibitory activities of extracts on strategic enzymes linked to human diseases were assessed. The antioxidant properties were evaluated in vitro, using six standard bioassays. The phenolic and anthraquinone profiles were also established using HPLC-PDA. Zinc, cadmium, lead, and copper contents were also determined. All the samples inhibited acetylcholinesterase (from 1.51 to 2.20 mg GALAEs/g extract), tyrosinase (from 7.50 to 25.3 mg KAEs/g extract), and α-amylase (from 0.37 to 0.51 mmol ACAEs/g extract). Aloe-emodin and physcion were present in all parts, while rhein was not detected. The phenolic profile and the heavy metals composition of specimens gathered from three different regions of Italy were different. It can be argued that samples collected near the street can contain higher concentrations of heavy metals. The experimental data confirm that the A. lutea species could be considered as a potential source of bioactive metabolites, and its consumption could play a positive and safe role in human health maintenance.

Graminex Pollen: Phenolic Pattern, Colorimetric Analysis and Protective Effects in Immortalized Prostate Cells (PC3) and Rat Prostate Challenged with LPS

“…The in vitro antioxidant effects induced by the pollen extract are consistent with the reported antiradical role of polyphenolic constituents of bee pollen [ 32 , 33 ]. On the other hand, it is not possible to exclude direct interactions between the treatments present in cell medium.…”

A Review of Biologically Active Natural Products from Mediterranean Wild Edible Plants: Benefits in the Treatment of Obesity and Its Related Disorders

“…Melucci and co-workers evaluated the α-amylase and α-glucosidase inhibitory potential of extracts from Asphodeline lutea Reichenb., collected in diverse sites in the Italian Central Apennines, at different phenological stages [38]. The results showed that the samples possessed high α-glucosidase-inhibitory effects, particularly the roots of flowering samples.…”

HPLC–PDA Polyphenolic Quantification, UHPLC–MS Secondary Metabolite Composition, and In Vitro Enzyme Inhibition Potential of Bougainvillea glabra

“…The inhibition of clinically relevant enzymes could be considered as an essential therapeutic approach for managing global health issues [16]. The present research work was carried out to evaluate the inhibition potential of B. glabra aerial and flower extracts against three clinically significant enzymes involved in most common pathologies including skin problems (tyrosinase), diabetes (α-amylase), and inflammatory disorders (lipoxygenase (LOX)); the results are presented in Table 4.…”

“…Compact (LabService, Anzola dell'Emilia, Italy). Gradient elution was performed using the mobile phase water-acetonitrile (93:7, v/v, 3% acetic acid) as reported in the literature [16,17]. All prepared sample solutions were centrifuged, and the supernatant was injected into the stock solutions of phenolics made at a concentration of 1 mg/mL in a final volume of 10 mL of methanol.…”