A comparative antibacterial activity and cytocompatibility for different top layers of TiN, Ag or TiN-Ag on nanoscale TiN/Ag multilayers

Zhao, Mengli; Gong, Huanhuan; Ma, Ming; Dong, Lei; Huang, Mengjun; Wan, Rongxin; Gu, Haitao; Kang, Y.B.; Li, Dejun

doi:10.1016/j.apsusc.2018.12.159

Cited by 33 publications

(5 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…where A and B are the average numbers of viable bacterial colonies (cfu/mL) on the uncoated Ti-6Al-4V and the as-deposited coatings, respectively. The viable bacterial were counted according to the National Standard of China GB/T 4789.2 [27]. Prior to SEM observations of bacterial cells, the bacteria were fixed with 2.5% glutaraldehyde solution and then and dehydrated with 60%, 80%, 90% and 100% ethanol for 10 min each.…”

Section: Antibacterial Activity Testsmentioning

confidence: 99%

In vitro antibacterial properties of MoO3/SiO2/Ag2O nanocomposite coating prepared by double cathode glow discharge technique

Zhao

et al. 2020

Surface and Coatings Technology

View full text Add to dashboard Cite

To obtain a self-disinfecting surface to combat nosocomial infections, in situ synthesis of the MoO 3-SiO 2-Ag 2 O nanocomposite antibacterial coating was prepared onto Ti-6Al-4V substrate via a double cathode glow discharge technique conducted in a Ar + O 2 gas mixture. The phase composition, microstructure and chemical structure of the as-prepared coating were systematically characterized by means of a series of microscopic examination methods. The microstructure of the coating exhibited an amorphous/nanocrystalline architecture, and both the MoO 3 and Ag 2 O crystallites were evenly embedded in an amorphous SiO 2 matrix. Photocatalytic activities of the coating were evaluated by photodegradation of rhodamine B (RhB) dye. The results showed that the introduction of Ag 2 O enhanced photocatalytic activity of the MoO 3-SiO 2 nanocomposite coating. In vitro antibacterial activity of the MoO 3-SiO 2-Ag 2 O coating against Gram-negative bacteria, Gram-positive bacteria and fungi were investigated and compared with that of the MoO 3-SiO 2 coating under both dark and visible light conditions. The MoO 3-SiO 2-Ag 2 O coating possessed higher bactericidal activities than the MoO 3-SiO 2 coating, due to the combined effects of surface hydrophobicity, the release of Ag + ions, surface acidic reaction and photocatalytic activity.

show abstract

Section: Antibacterial Activity Testsmentioning

confidence: 99%

In vitro antibacterial properties of MoO3/SiO2/Ag2O nanocomposite coating prepared by double cathode glow discharge technique

Zhao

et al. 2020

Surface and Coatings Technology

View full text Add to dashboard Cite

show abstract

“…40 Based on the above antibacterial mechanisms and the results of silver ion release in the solution, it can be deduced that silver ion sterilization is not the key antibacterial mechanism of silverloaded TiN/Ag-modified SLA-Ti surfaces, and that neutral metallic silver (Ag0) on the SLA/1 × 10 17 -Ag and SLA/1 × 10 18 -Ag surfaces play a dominant role in exerting the antibacterial effect. The underlying factors leading to the antibacterial effects of Ag-NPs are similar to those reported by Zhao et al, 17 Cao and co-workers, 40 and Zhu et al 41 Figure 7 shows the possible antibacterial mechanism of the silver-loaded TiN/Ag-modified SLA-Ti surfaces.…”

Section: In Vitro Bacteriostasis Assays and Possible Antibacterial Me...mentioning

confidence: 99%

“…In this study, TiN/Ag multilayers were synthesized on micro/nanotitanium surfaces using a multiarc ion-plating system (SA-6T, China). TiN is commonly selected as the top layer because of its exceptional hardness, wear resistance, corrosion resistance, and favorable biocompatibility. − However, it should be noted that TiN may not possess sufficient antibacterial properties. To ensure the baseline antibacterial properties of the top layer, it was necessary to implant an appropriate dose of Ag ions on the surface of the TiN/Ag multilayer film.…”

Section: Introductionmentioning

confidence: 99%

Adjusting the Dose of Ag-Ion Implantation on TiN–Ag-Modified SLA-Ti Creates Different Micronanostructures: Implications on Bacteriostasis, Biocompatibility, and Osteogenesis in Dental Implants

Ma,

Zhao,

et al. 2023

ACS Omega

Self Cite

View full text Add to dashboard Cite

The prevention of aseptic loosening and peri-implantitis is crucial for the success of dental implant surgery. In this study, different doses of Ag-implanted TiN/Ag nanomultilayers were prepared on the sandblasting with large grit and acid etching (SLA)-Ti surface using a multiarc ion-plating system and an ion-implantation system, respectively. The physical and chemical properties of the samples were assessed using various techniques, including scanning electron microscopy, energy-dispersive spectroscopy, X-ray diffraction, X-ray photoelectron spectroscopy, atomic force microscopy, inductively coupled plasma atomic emission spectrometry, and water contact angle measurements. In addition, the applicability and biosafety of the SLA/1 × 1017-Ag and SLA/1 × 1018-Ag surfaces were determined via biocompatibility testing in vivo and in vitro. The results demonstrated that the physical and chemical properties of SLA/1 × 1017-Ag and SLA/1 × 1018-Ag surfaces were different to some extent. However, compared with SLA-Ti, silver-loaded TiN/Ag-modified SLA-Ti surfaces (SLA/1 × 1018-Ag) with enhanced bacteriostatis, osteogenesis, and biocompatibility have great potential for dental applications.

show abstract

“…One way to add the antimicrobial function consist on doping a hard coating, such as the pioneering TiN coating, with metallic elements with known antimicrobial effect, e.g. Ag, Cu… [10][11][12][13][14][15][16] Specifically silver shows a strong bactericidal activity even at low concentrations, low toxicity, and most importantly abroad antibacterial spectrum against planktonic and sessile, Gram-positive and Gramnegative, and also multi drug-resistant bacteria. [17][18][19][20] In this regard, this study has aimed at evaluating of the electrotribological and anti-microbial properties of PVD deposited TiN-Ag thin films with a wide range of silver concentrations.…”

Section: Introductionmentioning

confidence: 99%

TiN-Ag as an antimicrobial and wear resistant coating

et al. 2021

View full text Add to dashboard Cite

Nosocomial infections are a major clinical concern, posing great risks for patients and rising costs for health services providers. This work aims at developing a hard, wear resistant coating, whose antimicrobial properties shall prevent the transmission of infections.TiN coatings deposited by Physical Vapour Deposition, PVD, with different Ag contents have been studied, especially in relation to the hardness and adhesion, their microstructure and morphology. The antimicrobial activity of the surfaces has been assessed against Staphylococcus epidermidis at different time frames, one of the most troublesome source of infections in trauma and orthopaedic surgeries. The electro-tribology properties of different silver contest have been studied. Finally, the coatings have been deposited on surgical acetabular reamers and wear resistance tests have been carried out against synthetic composite bone (simulating cortical and cancellous bone).Results have shown a good coating adhesion on stainless steel (both quantitatively in the scratch tests and qualitatively in the tests against synthetic composite bone), while the hardness decreased with higher Ag percentages. Furthermore, coatings exhibited antimicrobial activity against S.epidermidis, limited silver release, a remarkable wear resistance (vs. uncoated surgical acetabular reamers), while the electrical contact resistance provided valuable information about the evolution of friction and the status of the coating. Therefore TiN-Ag coatings present promising features for reducing the risk of infections, monitoring and extending cutting edge life and quality, and thus limiting damage to living tissues, e.g. necrosis.

show abstract

A comparative antibacterial activity and cytocompatibility for different top layers of TiN, Ag or TiN-Ag on nanoscale TiN/Ag multilayers

Cited by 33 publications

References 35 publications

In vitro antibacterial properties of MoO3/SiO2/Ag2O nanocomposite coating prepared by double cathode glow discharge technique

In vitro antibacterial properties of MoO3/SiO2/Ag2O nanocomposite coating prepared by double cathode glow discharge technique

Adjusting the Dose of Ag-Ion Implantation on TiN–Ag-Modified SLA-Ti Creates Different Micronanostructures: Implications on Bacteriostasis, Biocompatibility, and Osteogenesis in Dental Implants

TiN-Ag as an antimicrobial and wear resistant coating

Contact Info

Product

Resources

About