A comparative analysis of various flavonoids in the regulation of obesity and diabetes: An in vitro and in vivo study

Varshney, Ritu; Mishra, Rutusmita; Das, Neeladrisingha; Sircar, Debabrata; Roy, Partha

doi:10.1016/j.jff.2019.05.004

Cited by 47 publications

(22 citation statements)

References 52 publications

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“…This paper also confirmed the bioavailability and lipid-lowering effects of plant-originated phenolic compounds, especially hydroxycinnamic acids. Moreover, hydroxycinnamic acids were not only effective in the reduction of lipid accumulation but also upregulated the glucose transporter 4 (GLUT4) expression and glucose uptake [ 44 ], which is in agreement with observed enhanced 2-NBDG analogue uptake by HepG2 treated with PJ and DPJ.…”

Section: Discussionsupporting

confidence: 68%

The Effect of Simulated In Vitro Digestion on Biological Activity of Viburnum opulus Fruit Juices

et al. 2021

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In the present study, an in vitro digestion method has been used to assay the influence of the physiological conditions in the mouth, stomach, and intestine on the stability and activity in different cell models of the main phenolic compounds from Viburnum opulus fresh juice (FJ), phenolic-rich juice (PJ), and the bioavailable fractions (DFJ and DPJ). The data obtained indicate that the V. opulus samples achieved after in vitro digestion had an influence on cellular glucose and lipid metabolism. The bioavailable fraction of both digested juices stimulated glucose uptake and decreased lipid accumulation by L6 myoblasts and HepG2 hepatocytes. Both DFJ and DPJ reduced the secretion of inflammatory cytokines by 3T3-L1 adipocytes: interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α). Simultaneously, DFJ and DPJ enhanced oxidative stress in MIN6 cells and decreased glucose-stimulated insulin secretion (GSIS). UPLC–MS analysis revealed qualitative and quantitative changes in hydroxycinnamic acids. In particular, the content of chlorogenic acid decreased drastically; its content in the bioavailable fraction was almost 7 times and 30 times lower than in the FJ and PJ, respectively. Our results suggested that although the phenolic compounds of V. opulus juices undergo transformation during digestion, they are still potent antioxidant agents with biological activity.

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Section: Discussionsupporting

confidence: 68%

The Effect of Simulated In Vitro Digestion on Biological Activity of Viburnum opulus Fruit Juices

et al. 2021

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“…According to the present findings, CTFV surpassed PFV (functional foods to help reduce body fat) and fenofibrate (a lipid-lowering drug) in reducing body weight gain, hepatic fat or mass, body fats, adipocyte size, serum or liver triacylglycerol, leptin, the atherogenic index, and nitrite, as well as in increasing adiponectin and SOD. The possible mechanisms of the strong anti-obesity ability of CTFV might be due to the presence of metabolites and substances such as chlorogenic acid, caffeic acid, rutin, gastrodin, 4-hydroxybenzoic acid, parishin A, and acetic acid in CTFV, which were known to have anti-oxidative 32,89,90 , anti-obesity 11,18,[90][91][92][93][94][95] , cardioprotective 89,95 , and anti-inflammatory effects 11,95 . www.nature.com/scientificreports/ Liver steatosis and nonalcoholic fatty liver are the most common chronic liver disease.…”

Section: Discussionmentioning

confidence: 99%

Short-term Cudrania tricuspidata fruit vinegar administration attenuates obesity in high-fat diet-fed mice by improving fat accumulation and metabolic parameters

Choi

Kim

Yeo

et al. 2020

Sci Rep

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Previous studies have suggested that vinegar intake can help to reduce body fat and hyperglycemia. Therefore, this study aimed to evaluate the anti-obesity efficacy of vinegar fermented using Cudrania tricuspidata fruits (CTFV) and its main phenolic constituents and to analyze its molecular mechanism and changes in obesity-related metabolizing enzymatic activities. We found that HFD significantly caused hepatic steatosis; increases in body fats, feed efficiency, liver mass, lipids, insulin, oxidative parameters, cardiovascular-associated risk indices, lipase and α-amylase activities, whereas CTFV efficaciously attenuated HFD-induced oxidant stress, fat accumulation, obesity-related enzymatic activity, and the activation or reduction of obesity-related molecular reactions via improving metabolic parameters including phosphorylated insulin receptor substrate 1, protein tyrosine phosphatase 1B, phosphorylated phosphoinositide 3-kinase/protein kinase B, phosphorylated mitogen-activated protein kinases, sterol regulatory element-binding protein 1c, CCAAT/enhancer-binding protein, and fatty acid synthase; and decreases in adiponectin receptor 1, leptin receptor, adenosine monophosphate-activated protein kinase, acetyl-CoA carboxylase, and peroxisome proliferator-activated receptor, subsequently ameliorating HFD-induced obesity. Therefore, CTFV might provide a functional food resource or nutraceutical product for reducing body fat accumulation.

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“…Many researchers have discovered a wide range of biological activities of the flavonoids in prevention and relieve various diseases such as obesity, diabetes, cancer, angiocardiopathy, and heart diseases [ 5 – 7 ]. Therefore, the flavonoids were considered to be candidates for these disease management due to the ROS and iNOS caused [ 8 ]. The capacity of flavonoids depends on their substituent groups, the number of hydroxyl groups, other substitutions, and conjugations.…”

Section: Introductionmentioning

confidence: 99%

Identification of Six Flavonoids as Novel Cellular Antioxidants and Their Structure-Activity Relationship

Zhang

Yang

Liu

et al. 2020

Oxidative Medicine and Cellular Longevity

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This study is aimed at determining the relationship of flavonoid structures to their chemical and intracellular antioxidant activities. The antioxidant activities of 60 flavonoids were investigated by three different antioxidant assays, including 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity, oxygen radical absorption capacity (ORAC), and cellular antioxidant activity (CAA) assays. The result showed 6 flavonoids as good cellular antioxidants evaluated for the first time. The cellular antioxidant activities of compounds 7-methoxy-quercetin, 3-O-methylquercetin, 8-hydroxy-kaempferol, quercetin-3-O-α-arabinofuranose, kaempferol-7-O-glucopyranoside, and luteolin6-C-glucoside were linked with the upregulation of antioxidant enzyme activities (superoxide dismutase, catalase, and glutathione peroxidase). A structure-activity relationship suggested that 2,3-double bond, 4-keto groups, 3′,4′-catechol structure, and 3-hydroxyl in the flavonoid skeleton played important roles in the antioxidant behavior. Furthermore, the cell proliferative assay revealed a low cytotoxicity for 3-O-methylquercetin. The present results provide valuable information for the dietary application of flavonoids with different structures for high antioxidant.

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A comparative analysis of various flavonoids in the regulation of obesity and diabetes: An in vitro and in vivo study

Cited by 47 publications

References 52 publications

The Effect of Simulated In Vitro Digestion on Biological Activity of Viburnum opulus Fruit Juices

The Effect of Simulated In Vitro Digestion on Biological Activity of Viburnum opulus Fruit Juices

Short-term Cudrania tricuspidata fruit vinegar administration attenuates obesity in high-fat diet-fed mice by improving fat accumulation and metabolic parameters

Identification of Six Flavonoids as Novel Cellular Antioxidants and Their Structure-Activity Relationship

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