A comparative analysis of gut microbial dysbiosis by select antibiotics and DSS to understand the effects of perturbation on the host immunity and metabolism

Mukhopadhyay, Sohini; Ray, Pratikshya; Aich, Palok

doi:10.1016/j.lfs.2022.121212

Cited by 5 publications

(2 citation statements)

References 79 publications

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“…Intestinal permeability assay FITC-dextran was obtained for the evaluation of intestinal permeability. 15 Briefly, after being deprived of water and food for 4 h, each mouse was gavaged with 4 kDa FITC-dextran (44 mg per 100 g body weight). Blood was collected by eyeball extraction 4 h later.…”

Section: Biochemical Detectionmentioning

confidence: 99%

Agaricus bisporus polysaccharides ameliorate ulcerative colitis in mice by modulating gut microbiota and its metabolism

Liu,

Wang,

Yuan

et al. 2024

Food Funct.

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Section: Biochemical Detectionmentioning

confidence: 99%

Agaricus bisporus polysaccharides ameliorate ulcerative colitis in mice by modulating gut microbiota and its metabolism

Liu,

Wang,

Yuan

et al. 2024

Food Funct.

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“…[22,23] Also, the extent of perturbation depends on the class, spectrum, and duration (broad or narrow) of the antibiotics treated. [24,25] This antibiotic-mediated gut microbiota perturbation is linked to alteration in intestinal epithelial gene expression, [26] barrier function, [27] immune cell homeostasis, and response. [28,29] The pathophysiological impact of dysbiosis is limited to not only the gut but also energy expenditure, [30] longevity, [31] brain function, and gene expression [32][33][34] in early life as well as adulthood.…”

Section: Introductionmentioning

confidence: 99%

Postnatal 14D is the Key Window for Mice Intestinal Development‐ An Insight from Age‐Dependent Antibiotic‐Mediated Gut Microbial Dysbiosis Study

2023

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The postnatal period is one of the critical windows for the structure-function development of the gastrointestinal tract and associated mucosal immunity. Along with other constituent members, recent studies suggest the contribution of gut microbiota in maintaining host health, immunity, and development. Although the gut microbiota's role in maintaining barrier integrity is known, its function in early life development still needs to be better understood. To understand the details of gut microbiota's effects on intestinal integrity, epithelium development, and immune profile, the route of antibiotic-mediated perturbation is taken. Mice on days 7(P7D), 14(P14D), 21(P21D) and 28(P28D) are sacrificed and 16S rRNA metagenomic analysis is performed. The barrier integrity, tight junction proteins (TJPs) expression, intestinal epithelial cell (IEC) markers, and inflammatory cytokines are analyzed. Results reveal a postnatal age-related impact of gut microbiota perturbation, with a gradual increase in the relative abundance of Proteobacteria and a reduction in Bacteroidetes and Firmicutes. Significant barrier integrity disruption, reduced TJPs and IECs marker expression, and increased systemic inflammation at P14D of AVNM-treated mice are found. Moreover, the microbiota transplantation shows recolonization of Verrucomicrobia, proving a causal role in barrier functions. The investigation reveals P14D as a critical period for neonatal intestinal development, regulated by specific microbiota composition.

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Decoding the role of the gut microbiome in gut-brain axis, stress-resilience, or stress-susceptibility: A review

Sah,

Nandan,

et al. 2024

Asian Journal of Psychiatry

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A comparative analysis of gut microbial dysbiosis by select antibiotics and DSS to understand the effects of perturbation on the host immunity and metabolism

Cited by 5 publications

References 79 publications

Agaricus bisporus polysaccharides ameliorate ulcerative colitis in mice by modulating gut microbiota and its metabolism

Agaricus bisporus polysaccharides ameliorate ulcerative colitis in mice by modulating gut microbiota and its metabolism

Postnatal 14D is the Key Window for Mice Intestinal Development‐ An Insight from Age‐Dependent Antibiotic‐Mediated Gut Microbial Dysbiosis Study

Decoding the role of the gut microbiome in gut-brain axis, stress-resilience, or stress-susceptibility: A review

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