Decoding the role of the gut microbiome in gut-brain axis, stress-resilience, or stress-susceptibility: A review

Sah, Ranjay Kumar; Nandan, Amritasree; KV, Athira; S, Prashant; S, Sathianarayanan; Jose, Asha; Venkidasamy, Baskar; Nile, Shivraj Hariram

doi:10.1016/j.ajp.2023.103861

Cited by 7 publications

(2 citation statements)

References 261 publications

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“…[20][21][22] Further investigations are needed in the field of the gut microbiome for the elucidation of the mechanisms by which gut dysbiosis contributes to the pathophysiology of neuropsychiatric disorders. 23,24 In adiccion stress is related to socio-economic adversity -but not overall early life stressis associated with a less diverse microbiome in the general population. 25,26 The specific objective is to identify stress levels in individuals during the COVID-19 pandemic, Tumbes 2022.…”

Section: Health Psychology Researchmentioning

confidence: 99%

DNA metabarcoding technology for the identification of the fecal microbiome in patients with chronic stress

Pérez Urruchi,

Ramírez Elizalde,

Zapata Cornejo

et al. 2024

Health Psychology Research

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In the latest research, the concept of stress is associated with the deregulation of several biological systems sensitive to stress, such as the immune system, the microbiome, the endocrine system and neuroanatomical substrates. The objective of the research was to identify the fecal microbiome in patients diagnosed with chronic stress and in healthy patients through a metabarcoding analysis. The methodology used fecal samples collected from 20 patients with stress and 20 healthy patients. For the diagnosis of stress, psychological tools previously validated by external researchers were used. For metabarcoding analysis, metagenomic DNA extraction was performed from the fecal samples. Next Generation Illumina genetic sequencing targeting the 16S rDNA gene was then performed, followed by bioinformatic analysis using QUIME II software. The results, at the psychological test level, 20 people with chronic stress were diagnosed, on the other hand, at the metabarcoding level, specifically at the Gender level, the Asteroleplasma bacteria present only in the 20 healthy patients was molecularly identified. On the other hand, the bacteria Alistipes and Bifidobacterium were identified with greater predominance in the 20 patients with stress. Concluding, the bacteria Alistipes and Bifidobacterium are candidates as possible markers of the intestinal microbiome in patients with chronic stress, and the bacteria Asteroleplasma are candidates as a bacterial marker of the intestinal microbiome in healthy people. Finally, the identification of the microbiome in patients with stress opens a new path to understanding stress and its relationship to dysregulation with the microbiome.

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Section: Health Psychology Researchmentioning

confidence: 99%

DNA metabarcoding technology for the identification of the fecal microbiome in patients with chronic stress

Pérez Urruchi,

Ramírez Elizalde,

Zapata Cornejo

et al. 2024

Health Psychology Research

View full text Add to dashboard Cite

show abstract

“…Meanwhile, there exists a bidirectional signaling pathway between the gut and the brain, known as the gut-brain axis. This axis involves various pathways, including neural, endocrine, and immune signaling, allowing the gut microbiota to influence the central nervous system (6)(7)(8). Researches have already identified a potential association between alterations in the composition of the gut microbiota and the risk of GBM (6,9).…”

Section: Introductionmentioning

confidence: 99%

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Unraveling the Role of the Blood-Brain Barrier in the Pathophysiology of Depression: Recent Advances and Future Perspectives

Varghese,

Patel,

Nandan

et al. 2024

Mol Neurobiol

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Decoding the role of the gut microbiome in gut-brain axis, stress-resilience, or stress-susceptibility: A review

Cited by 7 publications

References 261 publications

DNA metabarcoding technology for the identification of the fecal microbiome in patients with chronic stress

DNA metabarcoding technology for the identification of the fecal microbiome in patients with chronic stress

Table_10.XLSX

Unraveling the Role of the Blood-Brain Barrier in the Pathophysiology of Depression: Recent Advances and Future Perspectives

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