A comparative analysis of core needle biopsy and final excision for breast cancer: histology and marker expression

Ough, Matthew; Velasco, Josè M.; Hieken, Tina J.

doi:10.1016/j.amjsurg.2010.02.015

Cited by 37 publications

(42 citation statements)

References 11 publications

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“…For p53, the concordance rate was 76.7% in our study, which is similar to the results of Ough et al [15]. Other studies have reported concordance rates of 85-100% [7].…”

Section: Disclosure Statementsupporting

confidence: 82%

“…Ough et al [15] and Arnedos et al [8] reported concordance rates of 78 and 85%, respectively for PR, while this rate was 90% in our study. Furthermore, our results showed a higher sensitivity (93.7%) and specificity (85.7%).…”

Section: Resultscontrasting

confidence: 52%

“…Kappa statistical analysis was used to measure the agreement between the 2 tests. Kappa values were defined as follows: 0, none; 0-0.2, slight; 0.2-0.4, fair; 0.4-0.6, moderate; 0.6-0.8, substantial; and 0.8-1.0, complete [15].…”

Section: Methodsmentioning

confidence: 99%

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Accuracy of Prognostic and Predictive Markers in Core Needle Breast Biopsies Compared with Excisional Specimens

et al. 2014

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Background: Core needle biopsy (CNB) is widely accepted for preoperative diagnosis of breast cancer and sometimes can be the only way of providing a suitable specimen for prognostic and predictive marker studies prior to neoadjuvant treatment. The purpose of this study was to evaluate the accuracy of CNB by comparing histological tumor type and grade as well as estrogen receptor (ER), progesterone receptor (PR), p53, and HER2/neu status by immunohistochemistry in CNB and excisional surgical specimens. Patients and Methods: During a 2.5-year study period, we identified 30 patients with breast cancer, who underwent CNB and definitive surgery. To evaluate the accuracy of CNB, tumor grade, ER, PR, HER2, and p53 status were immunohistochemically determined in both the CNB and the surgical specimens, and concordance of results between the 2 specimens was assessed. Results: The concordance rate was 100% for histological type, 66.6% for histological grade, and 96.7, 90, 76.7 and 93.3% for ER, PR, p53 and HER2/neu, respectively. Conclusion: Our study showed that CNB has an excellent accuracy for tumor type, ER, and HER2/neu; however, it should be used cautiously for tumor grade, PR, and p53 status. Thus, excisional biopsy is recommended for the determination of these factors.

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“…For p53, the concordance rate was 76.7% in our study, which is similar to the results of Ough et al [15]. Other studies have reported concordance rates of 85-100% [7].…”

Section: Disclosure Statementsupporting

confidence: 82%

Section: Resultscontrasting

confidence: 52%

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Accuracy of Prognostic and Predictive Markers in Core Needle Breast Biopsies Compared with Excisional Specimens

et al. 2014

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“…As well, neoadjuvant treatment, when indicated, can be based on the grade assessment and HR status of the CNBS. In cases of complete pathologic response, this will be the only source for evaluation of HR (1, 2). It can also determine the HR status more accurately than the IHC exam of an excised tumor with partial response to neoadjuvant chemotherapy.…”

Section: Discussionmentioning

confidence: 99%

“…In modern practice, the diagnosis of breast cancer is completed through the histological exam of core needle biopsy (CNB) samples(1). One of the important issues in treatment planning is the hormone receptor (HR) status of the tumor which can be assessed by immunohistochemitry (IHC) on the CNB specimens (CNBS) or over the subsequent surgical sample (SS).When neoadjuvant therapies are necessary preoperatively, decision making would necessarily be based on the evaluation of the needle biopsy samples (2).…”

Section: Introductionmentioning

confidence: 99%

Accuracy of Estrogen and Progesterone Receptor Assessment in Core Needle Biopsy Specimens of Breast Cancer

Omranipour¹,

Alipour²,

Hadji³

et al. 2013

Iran Red Crescent Med J

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BackgroundDiagnosis of breast cancer is completed through core needle biopsy (CNB) of the tumors but there is controversy on the accuracy of hormone receptor results on CNB specimens.ObjectivesWe undertook this study to compare the results of hormone receptor assessment in CNB and surgical samples on our patients.Patients and MethodsHormone receptor status was determined in CNB and surgical samples in breast cancer patients whose CNB and operation had been performed in this institute from 2009 to 2011 and had not undergone neoadjuvant chemotherapy.ResultsAbout 350 patients, 60 cases met all the criteria for entering the study. The mean age was 49.8 years. Considering a confidence interval (CI) of 95%, the sensitivity of ER and PR assessment in CNB was 92.9% and 81%, respectively and the specificity of both was 100%. The Accuracy of CNB was 98% for ER and 93% for PR.ConclusionsOur results confirm the acceptable accuracy of ER assessment on CNB. The subject needs further investigation in developing countries where omission of the test in surgical samples can be cost and time-saving.

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Meta-analysis of the concordance of histological grade of breast cancer between core needle biopsy and surgical excision specimen

Knuttel

Menezes

Diest

et al. 2016

British Journal of Surgery

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A comparative analysis of core needle biopsy and final excision for breast cancer: histology and marker expression

Cited by 37 publications

References 11 publications

Accuracy of Prognostic and Predictive Markers in Core Needle Breast Biopsies Compared with Excisional Specimens

Accuracy of Prognostic and Predictive Markers in Core Needle Breast Biopsies Compared with Excisional Specimens

Accuracy of Estrogen and Progesterone Receptor Assessment in Core Needle Biopsy Specimens of Breast Cancer

Meta-analysis of the concordance of histological grade of breast cancer between core needle biopsy and surgical excision specimen

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