A Compact, Large-Aperture Tunable Lens with Adaptive Spherical Correction

Wapler, Matthias C.; Stürmer, Moritz; Wallrabe, Ulrike

doi:10.1109/isot.2014.39

Cited by 12 publications

(11 citation statements)

References 7 publications

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“…Our adaptive lens is an advanced version of the lens introduced in 31 and consists of a 50 µm thin glass membrane, which is glued in-between two piezo rings ( Fig. 2, inset).…”

Section: Resultsmentioning

confidence: 99%

Diffraction-limited axial scanning in thick biological tissue with an aberration-correcting adaptive lens

Philipp

Lemke

Scholz

et al. 2019

Sci Rep

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Diffraction-limited deep focusing into biological tissue is challenging due to aberrations that lead to a broadening of the focal spot. The diffraction limit can be restored by employing aberration correction for example with a deformable mirror. However, this results in a bulky setup due to the required beam folding. We propose a bi-actuator adaptive lens that simultaneously enables axial scanning and the correction of specimen-induced spherical aberrations with a compact setup. Using the bi-actuator lens in a confocal microscope, we show diffraction-limited axial scanning up to 340 μm deep inside a phantom specimen. The application of this technique to in vivo measurements of zebrafish embryos with reporter-gene-driven fluorescence in a thyroid gland reveals substructures of the thyroid follicles, indicating that the bi-actuator adaptive lens is a meaningful supplement to the existing adaptive optics toolset.

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“…Our adaptive lens is an advanced version of the lens introduced in 31 and consists of a 50 µm thin glass membrane, which is glued in-between two piezo rings ( Fig. 2, inset).…”

Section: Resultsmentioning

confidence: 99%

Diffraction-limited axial scanning in thick biological tissue with an aberration-correcting adaptive lens

Philipp

Lemke

Scholz

et al. 2019

Sci Rep

Self Cite

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“…• Available non-magnetic adaptive lenses [26][27][28] provide a free aperture of 12 mm and a usable aperture around 8 to 9 mm at a focal power around ±10m −1 . An earlier version [28] of the adaptive lens had to be oriented horizontally to avoid distortions due to gravity.…”

Section: Optical Designmentioning

confidence: 99%

MR-compatible optical microscope for in-situ dual-mode MR-optical microscopy

et al. 2021

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We present the development of a dual-mode imaging platform that combines optical microscopy with magnetic resonance microscopy. Our microscope is designed to operate inside a 9.4T small animal scanner with the option to use a 72mm bore animal RF coil or different integrated linear micro coils. With a design that minimizes the magnetic distortions near the sample, we achieved a field inhomogeneity of 19 ppb RMS. We further integrated a waveguide in the optical layout for the electromagnetic shielding of the camera, which minimizes the noise increase in the MR and optical images below practical relevance. The optical layout uses an adaptive lens for focusing, 2 × 2 modular combinations of objectives with 0.6mm to 2.3mm field of view and 4 configurable RGBW illumination channels and achieves a plano-apochromatic optical aberration correction with 0.6μm to 2.3μm resolution. We present the design, implementation and characterization of the prototype including the general optical and MR-compatible design strategies, a knife-edge optical characterization and different concurrent imaging demonstrations.

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“…The complete assambly is shown in figure 2. For a simplified analytical model of the bending mode, as derived in [18], we assume a spherical deformation and neglect forces, e.g. the bending stiffness of the piezo rings and the glass membrane.…”

Section: Operating Principle and Analytic Approximationmentioning

confidence: 99%

“…The main advantage of our design [18] is that we are able to control both, the defocus and the spherical aberrations simultaneously. In [19,20] we demonstrated experimentally that we can independently control the focal power and aspherical coefficient and also showed the achievable aspherical and focal tuning range for one of our lenses [19].…”

Section: Introductionmentioning

confidence: 99%

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Multiphysics simulation of the aspherical deformation of piezo-glass membrane lenses including hysteresis, fabrication and nonlinear effects

Lemke

Frey

Bruno

et al. 2019

Smart Mater. Struct.

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In this paper we present and verify the non-linear simulation of an aspherical adaptive lens based on a piezo-glass sandwich membrane with combined bending and buckling actuation. To predict the full non-linear piezoelectric behavior, we measured the non-linear charge coefficient, hysteresis and creep effects of the piezo material and inserted them into the FEM model using a virtual electric field. We further included and discussed the fabrication parameters -glue layers and thermal stress -and their variations. To verify our simulations, we fabricated and measured a set of lenses with different geometries, where we found good agreement and show that their qualitative behavior is also well described by a simple analytical model. We finally discuss the effects of the geometry on the electric response and find, e.g., an increased focal power range from ±4.5 to ±9 m −1 when changing the aperture from 14 to 10 mm.

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A Compact, Large-Aperture Tunable Lens with Adaptive Spherical Correction

Cited by 12 publications

References 7 publications

Diffraction-limited axial scanning in thick biological tissue with an aberration-correcting adaptive lens

Diffraction-limited axial scanning in thick biological tissue with an aberration-correcting adaptive lens

MR-compatible optical microscope for in-situ dual-mode MR-optical microscopy

Multiphysics simulation of the aspherical deformation of piezo-glass membrane lenses including hysteresis, fabrication and nonlinear effects

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