A compact fiber‐optic probe‐based singlet oxygen luminescence detection system

Gemmell, Nathan R.; McCarthy, Aongus; Kim, Michele M.; Veilleux, Israël; Zhu, Timothy C.; Buller, Gerald S.; Wilson, Brian C.; Hadfield, Robert H.

doi:10.1002/jbio.201600078

Cited by 24 publications

(25 citation statements)

References 29 publications

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“…Ongoing research is being pursued to improve photosensitizers, delivery methods, and dosimetry techniques so that there is higher tumor selectivity with drugs, a rapid accumulation in the target tissue to reduce the drug‐light interval, and rapid clearance to minimize post‐treatment photosensitivity. Dosimetry techniques are being developed for improved real‐time information of delivered dose to the target with more sophisticated methods, including explicit dosimetry, real‐time light dosimetry, and direct singlet oxygen luminescence dosimetry .…”

Section: Other Technologiesmentioning

confidence: 99%

Light Sources and Dosimetry Techniques for Photodynamic Therapy

Kim

Darafsheh

2020

Photochem & Photobiology

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267

225

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Effective treatment delivery in photodynamic therapy (PDT) requires coordination of the light source, the photosensitizer, and the delivery device appropriate to the target tissue. Lasers, light‐emitting diodes (LEDs), and lamps are the main types of light sources utilized for PDT applications. The choice of light source depends on the target location, photosensitizer used, and light dose to be delivered. Geometry of minimally accessible areas also plays a role in deciding light applicator type. Typically, optical fiber‐based devices are used to deliver the treatment light close to the target. The optical properties of tissue also affect the distribution of the treatment light. Treatment light undergoes scattering and absorption in tissue. Most tissue will scatter light, but highly pigmented areas will absorb light, especially at short wavelengths. This review will summarize the basic physics of light sources, and describe methods for determining the dose delivered to the patient.

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Section: Other Technologiesmentioning

confidence: 99%

Light Sources and Dosimetry Techniques for Photodynamic Therapy

Kim

Darafsheh

2020

Photochem & Photobiology

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267

225

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“…Singlet oxygen luminescence dosimetry (SOLD) was performed using a compact, fiberoptic near-infrared probe-based system [21,22]. The probe was coupled to a compact InGaAs/InP single photon avalanche diode (SPAD) detector (Micro Photon Devices, Bolzano Italy).…”

Section: Methodsmentioning

confidence: 99%

A Comparison of Singlet Oxygen Explicit Dosimetry (SOED) and Singlet Oxygen Luminescence Dosimetry (SOLD) for Photofrin-Mediated Photodynamic Therapy

Kim

Penjweini

Gemmell

et al. 2016

Cancers

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Accurate photodynamic therapy (PDT) dosimetry is critical for the use of PDT in the treatment of malignant and nonmalignant localized diseases. A singlet oxygen explicit dosimetry (SOED) model has been developed for in vivo purposes. It involves the measurement of the key components in PDT—light fluence (rate), photosensitizer concentration, and ground-state oxygen concentration ([3O2])—to calculate the amount of reacted singlet oxygen ([1O2]rx), the main cytotoxic component in type II PDT. Experiments were performed in phantoms with the photosensitizer Photofrin and in solution using phosphorescence-based singlet oxygen luminescence dosimetry (SOLD) to validate the SOED model. Oxygen concentration and photosensitizer photobleaching versus time were measured during PDT, along with direct SOLD measurements of singlet oxygen and triplet state lifetime (τΔ and τt), for various photosensitizer concentrations to determine necessary photophysical parameters. SOLD-determined cumulative [1O2]rx was compared to SOED-calculated [1O2]rx for various photosensitizer concentrations to show a clear correlation between the two methods. This illustrates that explicit dosimetry can be used when phosphorescence-based dosimetry is not feasible. Using SOED modeling, we have also shown evidence that SOLD-measured [1O2]rx using a 523 nm pulsed laser can be used to correlate to singlet oxygen generated by a 630 nm laser during a clinical malignant pleural mesothelioma (MPM) PDT protocol by using a conversion formula.

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“…Singlet oxygen luminescence dosimetry was performed using a compact, fiber optic probe-based singlet oxygen luminescence detection system [18]. The near-infrared luminescence probe was coupled to a compact InGaAs/InP single photon avalanche diode (SPAD) detector.…”

Section: Methodsmentioning

confidence: 99%

A feasibility study of singlet oxygen explicit dosmietry (SOED) of PDT by intercomparison with a singlet oxygen luminescence dosimetry (SOLD) system

et al. 2016

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An explicit dosimetry model has been developed to calculate the apparent reacted 1O2 concentration ([1O2]rx) in an in-vivo model. In the model, a macroscopic quantity, g, is introduced to account for oxygen perfusion to the medium during PDT. In this study, the SOED model is extended for PDT treatment in phantom conditions where vasculature is not present; the oxygen perfusion is achieved through the air-phantom interface instead. The solution of the SOED model is obtained by solving the coupled photochemical rate equations incorporating oxygen perfusion through the air-liquid interface. Experiments were performed for two photosensitizers (PS), Rose Bengal (RB) and Photofrin (PH), in solution, using SOED and SOLD measurements to determine both the instantaneous [1O2] as well as cumulative [1O2]rx concentrations, where [1O2]rx = (1/τΔ) · ∫[1O2]dt. The PS concentrations varied between 10 and 100 mM for RB and ~200 mM for Photofrin. The resulting magnitudes of [1O2] were compared between SOED and SOLD.

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A compact fiber‐optic probe‐based singlet oxygen luminescence detection system

Cited by 24 publications

References 29 publications

Light Sources and Dosimetry Techniques for Photodynamic Therapy

Light Sources and Dosimetry Techniques for Photodynamic Therapy

A Comparison of Singlet Oxygen Explicit Dosimetry (SOED) and Singlet Oxygen Luminescence Dosimetry (SOLD) for Photofrin-Mediated Photodynamic Therapy

A feasibility study of singlet oxygen explicit dosmietry (SOED) of PDT by intercomparison with a singlet oxygen luminescence dosimetry (SOLD) system

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