A compact breath acetone analyser based on an ultraviolet light emitting diode

Li, Jing; Smeeton, T. M.; Zanola, M.; Barrett, Jacob; Berryman-Bousquet, Valerie

doi:10.1016/j.snb.2018.05.114

Cited by 15 publications

(16 citation statements)

References 25 publications

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“…One of the cheapest and very effective methods to increase the detection limit is by using a gas preconcentration structure [ 29 , 30 ]. In addition, scientists are carrying out research for developing a single gas sensor which could cover the exhaled acetone range [ 31 ] and, crucially, work at room temperature [ 32 , 33 , 34 , 35 ], and includes microwave-based [ 36 , 37 ] and optical-based sensors [ 38 , 39 , 40 ]. That makes the process noninvasive, real-time, and less expensive compared to the traditional medical diagnosis methods.…”

Section: Introductionmentioning

confidence: 99%

Sensors for Enhanced Detection of Acetone as a Potential Tool for Noninvasive Diabetes Monitoring

Rydosz

2018

Sensors

130

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Measurement of blood-borne volatile organic compounds (VOCs) occurring in human exhaled breath as a result of metabolic changes or pathological disorders is a promising tool for noninvasive medical diagnosis, such as exhaled acetone measurements in terms of diabetes monitoring. The conventional methods for exhaled breath analysis are based on spectrometry techniques, however, the development of gas sensors has made them more and more attractive from a medical point of view. This review focuses on the latest achievements in gas sensors for exhaled acetone detection. Several different methods and techniques are presented and discussed as well.

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Section: Introductionmentioning

confidence: 99%

Sensors for Enhanced Detection of Acetone as a Potential Tool for Noninvasive Diabetes Monitoring

Rydosz

2018

Sensors

130

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“…The result shows high linearity, and the correlation coefficient R 2 is 0.9995. We found that the measurement accuracy has a standard deviation of 0.074 ppm, which is a better value compared with the UV absorption measurement reported by Smeeton [ 30 ] (0.2 ppm). For healthy adults, the concentration of breath acetone is between 0.3 and 1.2 ppm [ 33 ], whereas, for diabetics, it is 1–10 ppm [ 36 ].…”

Section: Discussionmentioning

confidence: 41%

“…However, the system is complicated and expensive. Li et al proposed a compact analysis system for breath acetone using a cheap light-emitting diode that can produce 285 nm of UV light [ 30 ]. They also developed a compact multipath gas cell to enhance the sensitivity.…”

Section: Introductionmentioning

confidence: 99%

Vacuum Ultraviolet Absorption Spectroscopy Analysis of Breath Acetone Using a Hollow Optical Fiber Gas Cell

Kudo

Kino

Matsuura

2021

Sensors

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Human breath is a biomarker of body fat metabolism and can be used to diagnose various diseases, such as diabetes. As such, in this paper, a vacuum ultraviolet (VUV) spectroscopy system is proposed to measure the acetone in exhaled human breath. A strong absorption acetone peak at 195 nm is detected using a simple system consisting of a deuterium lamp source, a hollow-core fiber gas cell, and a fiber-coupled compact spectrometer corresponding to the VUV region. The hollow-core fiber functions both as a long-path and an extremely small-volume gas cell; it enables us to sensitively measure the trace components of exhaled breath. For breath analysis, we apply multiple regression analysis using the absorption spectra of oxygen, water, and acetone standard gas as explanatory variables to quantitate the concentration of acetone in breath. Based on human breath, we apply the standard addition method to obtain the measurement accuracy. The results suggest that the standard deviation is 0.074 ppm for healthy human breath with an acetone concentration of around 0.8 ppm and a precision of 0.026 ppm. We also monitor body fat burn based on breath acetone and confirm that breath acetone increases after exercise because it is a volatile byproduct of lipolysis.

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“…Evidence for currently available commercial ketone breathalyzers is lacking. Many studies have assessed the utility of novel sensors in the ketogenic diet [ 25 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 ], but very few have evaluated currently available devices. The BIOSENSE™ device is a breathalyzer with published clinical trial data detailing its efficacy.…”

Section: Current Technologymentioning

confidence: 99%

The Ketogenic Diet: Breath Acetone Sensing Technology

Alkedeh

Priefer

2021

Biosensors

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The ketogenic diet, while originally thought to treat epilepsy in children, is now used for weight loss due to increasing evidence indicating that fat is burned more rapidly when there is a low carbohydrate intake. This low carbohydrate intake can lead to elevated ketone levels in the blood and breath. Breath and blood ketones can be measured to gauge the level of ketosis and allow for adjustment of the diet to meet the user’s needs. Blood ketone levels have been historically used, but now breath acetone sensors are becoming more common due to less invasiveness and convenience. New technologies are being researched in the area of acetone sensors to capitalize on the rising popularity of the diet. Current breath acetone sensors come in the form of handheld breathalyzer devices. Technologies in development mostly consist of semiconductor metal oxides in different physio-chemical formations. These current devices and future technologies are investigated here with regard to utility and efficacy. Technologies currently in development do not have extensive testing of the selectivity of the sensors including the many compounds present in human breath. While some sensors have undergone human testing, the sample sizes are very small, and the testing was not extensive. Data regarding current devices is lacking and more research needs to be done to effectively evaluate current devices if they are to have a place as medical devices. Future technologies are very promising but are still in early development stages.

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A compact breath acetone analyser based on an ultraviolet light emitting diode

Cited by 15 publications

References 25 publications

Sensors for Enhanced Detection of Acetone as a Potential Tool for Noninvasive Diabetes Monitoring

Sensors for Enhanced Detection of Acetone as a Potential Tool for Noninvasive Diabetes Monitoring

Vacuum Ultraviolet Absorption Spectroscopy Analysis of Breath Acetone Using a Hollow Optical Fiber Gas Cell

The Ketogenic Diet: Breath Acetone Sensing Technology

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