A commercial treatment planning system with a hybrid dose calculation algorithm for synchrotron radiotherapy trials

Day, Liam; Donzelli, Mattia; Pellicioli, Paolo; Smyth, Lloyd M. L.; Barnes, Micah; Bartzsch, Stefan; Crosbie, Jack

doi:10.1088/1361-6560/abd737

Cited by 8 publications

(5 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The hybrid dose calculation algorithm was previously paired with the Eclipse TM treatment planning system (Varian Medical Systems, inc.), a commercially available graphical software routinely used for treatment planning in the clinic [47,48]. Eclipse TM was used to generate the phantom geometry and display the dose distribution, while the dose calculation was performed using the hybrid algorithm engine.…”

Section: Monte Carlo Simulations Of Depth Dose Profilementioning

confidence: 99%

Synchrotron x-ray spectra characterisation for radiation therapy applications at the ESRF - ID17 biomedical beamline

Di Manici,

Reyes-Herrera,

Day

et al. 2024

Phys. Scr.

Self Cite

View full text Add to dashboard Cite

Objective: Radiation therapy requires reliable dosimetry protocols to deliver successful treatments with high accuracy and precision. In this context, accurate knowledge of the beam’s energy spectra is mandatory. The goal of this study was to validate the synchrotron X-ray spectrum of the ID17 beamline at the European Synchrotron Radiation Facility (ESRF). The modification of the synchrotron storage ring and beamline in recent years necessitates a new characterisation of the radiation spectra of the ID17 beamline. The validated spectra will be a starting point for possible future clinical applications.Approach: The half value layer method was used to measure the attenuation of the X-ray spectrum in Al and Cu. Experimental data was validated against theoretical data produced using OASYS; an in-house developed software for calculating beamline spectra. Two different spectral configurations, “conventional” and “clinical”, were investigated. The characterised spectra were used to perform dosimetric validation of depth dose profiles measured in a water-equivalent phantom. The dose profile was measured using two different detectors and compared with calculations generated using two different Monte Carlo algorithms.Main results: The results showed good agreement between measured and predicted half value layers, with differences of less than 1%. Excellent agreement to within 3% was obtained, an agreement that satisfies the requirements in conventional radiotherapy for approvable treatment planning.Significance: Accurate spectra have been defined and validated for the ESRF – ID17 Biomedical beamline. The validated spectra can be used as input for future dosimetric studies and treatment planning systems in the context of preclinical studies and possible future clinical trials.

show abstract

Section: Monte Carlo Simulations Of Depth Dose Profilementioning

confidence: 99%

Synchrotron x-ray spectra characterisation for radiation therapy applications at the ESRF - ID17 biomedical beamline

Di Manici,

Reyes-Herrera,

Day

et al. 2024

Phys. Scr.

Self Cite

View full text Add to dashboard Cite

show abstract

“…There are some studies conducting the dose calculation accuracy of different TPS in more complex geometries. 14,27,59,24,23,[61][62][63] Bahreyni Toossi et al 27 quantified dose calculation accuracy of TiGRT TPS in a RANDO phantom. In that study, they planned two lateral parallel opposed fields on the head and neck region of the phantom, in which one of them was an open field and was wedged field.…”

Section: Evaluating the Dose Calculation Accuracy Of Isogray Tps Base...mentioning

confidence: 99%

Evaluation of dose calculation accuracy of a commercial radiotherapy treatment planning system for adjacent radiation fields

et al. 2023

View full text Add to dashboard Cite

Background: Adjacent radiation fields are applied in some radiotherapeutic cases. When using these radiation fields, considerable dose errors across the junction of radiation fields are possible. Therefore, it is necessary to evaluate the accuracy of the dose calculated by treatment planning system (TPS) when using the adjacent radiation fields. The present study aimed to quantify the dose calculation accuracy of ISOgray TPS for the photon-photon adjacent fields. Materials and methods: To assess the accuracy of dose calculations, the dose profiles were first measured by a Semiflex ionization chamber at 1, 1·5, 5 and 10 cm depths for different field sizes (6 × 6, 10 × 10 and 20 × 20 cm2), source to surface distances (SSDs) (90, 100 and 110 cm) and beam angles (0º, 15º, 30º and 45º). In the second step, the data at corresponding depths were extracted from the ISOgray TPS. Finally, the dosimetric performance of TPS was evaluated using a gamma index analysis. Results: The overall dose calculation accuracy of ISOgray TPS was within the acceptable range for the build-up region (with acceptance criteria of dose difference (DD) = 15% and distance to agreement (DTA) = 3 mm) and the depths after the build-up region (with acceptance criteria of DD = 5% and DTA = 3 mm). Moreover, the overall accuracy of dose calculations was not affected by the field size and the SSD. It was also shown that the accuracy of dose calculations was similar for the adjacent radiation fields with beam angles of 0º, 15 º and 30 º, while a considerable decrease in the pass rate values is obtained for the adjacent radiation field with 45 º beam angle. A more detailed analysis of the findings revealed that the accuracy of dose calculations in the match line regions of the adjacent radiation fields for 1 cm beam profiles was within the acceptable range; however, it declined for other depths. Conclusions: The findings showed that the overall dose calculation accuracy of ISOgray TPS was acceptable for evaluated adjacent radiation fields. However, the accuracy of dose calculations in the match line regions of the adjacent radiation fields for the depth after build-up was not within the acceptable range.

show abstract

“…Another challenge is the extreme high dose and dose rate that is required, although recent preclinical studies have shown that temporal fractionation of the dose delivery, into three sessions delivered over 3 days, may provide the same benefits [71]. Development of suitable treatment planning systems prior to studies in veterinary trials is also underway [72]. The recent interest in FLASH radiotherapy has led to renewed interest in the development of new compact accelerators that can deliver radiation at the high dose rates required for FLASH and potentially these could also be used to deliver MRT in the future in a more cost-effective manner [73,74].…”

Section: Future Developments and Clinical Utilitymentioning

confidence: 99%

A Brief Overview of the Preclinical and Clinical Radiobiology of Microbeam Radiotherapy

et al. 2021

View full text Add to dashboard Cite

Microbeam radiotherapy (MRT) is the delivery of spatially fractionated beams that have the potential to offer significant improvements in the therapeutic ratio due to the delivery of micron-sized high dose and dose rate beams. They build on longstanding clinical experience of GRID radiotherapy and more recently lattice-based approaches. Here we briefly overview the preclinical evidence for MRT efficacy and highlight the challenges for bringing this to clinical utility. The biological mechanisms underpinning MRT efficacy are still unclear, but involve vascular, bystander, stem cell and potentially immune responses. There is probably significant overlap in the mechanisms underpinning MRT responses and FLASH radiotherapy that needs to be further defined.

show abstract

A commercial treatment planning system with a hybrid dose calculation algorithm for synchrotron radiotherapy trials

Cited by 8 publications

References 43 publications

Synchrotron x-ray spectra characterisation for radiation therapy applications at the ESRF - ID17 biomedical beamline

Synchrotron x-ray spectra characterisation for radiation therapy applications at the ESRF - ID17 biomedical beamline

Evaluation of dose calculation accuracy of a commercial radiotherapy treatment planning system for adjacent radiation fields

A Brief Overview of the Preclinical and Clinical Radiobiology of Microbeam Radiotherapy

Contact Info

Product

Resources

About