A coming era of precision diagnostics based on nano-assisted mass spectrometry

Qian, Kun; Wan, Jingjing; Gurav, Deepanjali D.; Li, Rongxin

doi:10.33218/prnano1(2).180724.2

Cited by 8 publications

(3 citation statements)

References 51 publications

(62 reference statements)

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“…Recently, novel analytical systems were introduced to detect biomarkers for disease diagnosis. [26][27][28][29][30][31][32] The microfluidic chip is a technology for precise control of microfluidics in submicron structures. [33,34] The use of microfluidic chips can facilitate the accurate control and detection of microfluids in the micro and nanoscale space.…”

Section: Introductionmentioning

confidence: 99%

Construction of Exosome SORL1 Detection Platform Based on 3D Porous Microfluidic Chip and its Application in Early Diagnosis of Colorectal Cancer

Chen

et al. 2023

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Exosomes are promising new biomarkers for colorectal cancer (CRC) diagnosis, due to their rich biological fingerprints and high level of stability. However, the accurate detection of exosomes with specific surface receptors is limited to clinical application. Herein, an exosome enrichment platform on a 3D porous sponge microfluidic chip is constructed and the exosome capture efficiency of this chip is ≈90%. Also, deep mass spectrometry analysis followed by multi‐level expression screenings revealed a CRC‐specific exosome membrane protein (SORL1). A method of SORL1 detection by specific quantum dot labeling is further designed and the ensemble classification system is established by extracting features from 64‐patched fluorescence images. Importantly, the area under the curve (AUC) using this system is 0.99, which is significantly higher (p < 0.001) than that using a conventional biomarker (carcinoembryonic antigen (CEA), AUC of 0.71). The above system showed similar diagnostic performance, dealing with early‐stage CRC, young CRC, and CEA‐negative CRC patients.

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Section: Introductionmentioning

confidence: 99%

Construction of Exosome SORL1 Detection Platform Based on 3D Porous Microfluidic Chip and its Application in Early Diagnosis of Colorectal Cancer

Chen

et al. 2023

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“…The future of nano-diagnostics is marked by expanding capabilities, driven by advancements in nanotechnology and its application in medical diagnostics. A group of researchers discuss the era of precision diagnostics ushered in by nano-assisted mass spectrometry (Qian et al, 2018). This technique overcomes the limitations of accuracy in traditional diagnostic methods, particularly when dealing with complex diseases.…”

Section: Expanding Capabilities: the Future Of Nano-diagnosticsmentioning

confidence: 99%

Nanotechnology in U.S. Medical Diagnostics: A Comprehensive Review

Destiny Balogun,

Chukwudum Ohalete,

Chigozie Ani

et al. 2023

J. tech. innov.

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This comprehensive review evaluates the advancements, potential, and ethical implications of nanotechnology in medical diagnostics within the U.S. healthcare system. The primary objective was to assess how nano-tools are revolutionizing early disease detection and management. The methodology involved a systematic review of peer-reviewed literature, focusing on studies published between 2000 and 2023. Data sources included academic databases such as PubMed, Scopus, and Web of Science, supplemented by secondary sources like journals and conference proceedings. The study emphasized the historical development of nanotechnology in diagnostics, current innovations, and future prospects in the field. Key findings reveal significant advancements in nano-diagnostic tools, highlighting their increased sensitivity and specificity in early disease detection. Innovations such as nano-enabled imaging and targeted drug delivery systems have shown potential in personalizing patient care. However, the study also identified challenges, including ethical concerns related to patient privacy, data security, and the need for comprehensive regulatory frameworks. The review concludes that while nanotechnology in diagnostics offers transformative potential, it also presents unique challenges. Recommendations for industry leaders and policymakers include fostering innovation within ethical and safety boundaries, investing in research, and establishing clear regulatory guidelines. Future research directions emphasize long-term efficacy and safety studies, cost-effective manufacturing processes, and exploring new applications in disease management. This study underscores the pivotal role of nanotechnology in shaping the future of healthcare diagnostics.

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“…A variety of biosensor platforms based on plasmonic nanomaterials with enhancements such as sensor platforms, molecular detection, and cell receptor analysis show promising outlooks from clinical perspectives. 54 Qian et al reported two independent studies based on a MALDI MS approach using plasmonic nanoshells for in vitro diagnostics of early-stage lung cancer patients and individuals with post-operative brain infections. A clear separation between the healthy and patient groups was achieved by the metabolic fingerprinting of biofluids, such as serum, exosomes and cerebrospinal fluid ( Fig.…”

Section: Maldi Ms and Sers Based Diagnosticsmentioning

confidence: 99%