2006
DOI: 10.1152/physiolgenomics.00060.2006
|View full text |Cite
|
Sign up to set email alerts
|

A combined1H-NMR spectroscopy- and mass spectrometry-based metabolomic study of the PPAR-α null mutant mouse defines profound systemic changes in metabolism linked to the metabolic syndrome

Abstract: The mobilization of triacylglycerides from storage in adipocytes to the liver is a vital response to the fasting state in mammalian metabolism. This is accompanied by a rapid translational activation of genes encoding mitochondrial, microsomal, and peroxisomal beta-oxidation in the liver, in part under the regulation of peroxisome proliferator-activated receptor-alpha (PPAR-alpha). A failure to express PPAR-alpha results in profound metabolic perturbations in muscle tissue as well as the liver. These changes r… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
2

Citation Types

6
129
0

Year Published

2008
2008
2013
2013

Publication Types

Select...
5
4

Relationship

0
9

Authors

Journals

citations
Cited by 149 publications
(135 citation statements)
references
References 44 publications
6
129
0
Order By: Relevance
“…The metabolic alterations observed at different time-points suggest that time-dependent in vivo effects occur during the earlier period after STZ injection, which was in accord with a previous study for examining the metabolic differences between acute (72 h) and chronic (14 d) STZ-induced diabetes. 41 These time-dependent alterations might contribute to some differences between our observations and those of Zhang et al 20 Furthermore, being consistent with a previous study using the 11-week-old Zucker diabetic rat and PPAR-α null mice model, 42,43 the concentrations of several glucogenic amino acids were also decreased, indicative of higher rates of gluconeogenesis.…”
Section: Discussionsupporting
confidence: 91%
“…The metabolic alterations observed at different time-points suggest that time-dependent in vivo effects occur during the earlier period after STZ injection, which was in accord with a previous study for examining the metabolic differences between acute (72 h) and chronic (14 d) STZ-induced diabetes. 41 These time-dependent alterations might contribute to some differences between our observations and those of Zhang et al 20 Furthermore, being consistent with a previous study using the 11-week-old Zucker diabetic rat and PPAR-α null mice model, 42,43 the concentrations of several glucogenic amino acids were also decreased, indicative of higher rates of gluconeogenesis.…”
Section: Discussionsupporting
confidence: 91%
“…In fact, GLUT-4 repression has profound changes in cardiac dysfunction and arrhythmias with accelerated apoptotic cell death. Although it was not the aim of our investigation, it is interesting to note that it is unlikely that all of the observed cardiac protection by resveratrol occurred directly via PPAR-␣ target, and GLUT-4 gene repression or expression is probably also modulated via PPAR-␣-independent transcriptional regulatory pathways linked to alteration in cellular energy metabolism (4,6).…”
Section: Discussionmentioning
confidence: 98%
“…Before this study, there had been only a few studies that had investigated substrate fuel utilization and its regulation in PPAR␣ null mouse hearts (3,9,27,30,37), none of which had specifically examined the utilization and/or regulation of CHOs for energy production or anaplerosis. Using our ex vivo working heart model, we documented the impact of an increase in workload induced by raising the preload from 12 to 15 mmHg, which remains in the physiological range.…”
Section: Discussionmentioning
confidence: 99%