A Combined Modality for Anaplastic Largecell Carcinoma of the Thyroid

Kasai, N; Sakamoto, Atsuhiko; Uchida, Masaoki

doi:10.1016/s0385-8146(85)80033-x

Cited by 5 publications

(3 citation statements)

References 3 publications

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“…Our data indicate that patients with the anaplastic, follicular, and papillary variants of TCDM may benefit from multimodal therapy consisting of surgery and radiation. The literature supports the use of multimodal therapy methods 37,55–59 . However, these studies did not compare histological variants or account for the presence of metastatic disease as our study does.…”

Section: Discussionmentioning

confidence: 69%

The Benefit of Primary Tumor Surgical Resection in Distant Metastatic Carcinomas of the Thyroid

et al. 2020

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Objectives/Hypothesis Thyroid cancer with distant metastasis (TCDM) at diagnosis has significantly worse survival rates when compared to localized/regional thyroid cancer. This study sought to report on the characteristics of patients presenting with TCDM and the potential survival advantage of surgical resection. Study Design Data were acquired from the Surveillance, Epidemiology, and End Results (SEER) database with cases from 2004 to 2015. Methods TCDM cases (n = 2,558) were identified from the SEER database. The Bonferroni correction was applied for multivariate analysis. Kaplan‐Meier analysis was utilized to obtain disease‐specific survival (DSS) rates. Cox regression analysis was utilized to identify independent factors significantly associated with survival. Results The average age of diagnosis of TCDM was 62.0 (±17.5) years. Patients were predominantly white (74.6%), female (54.6%), in a relationship (56.0%), and between ages 36 and 80 years (76.4%). Cases consisted of papillary (57.2%), follicular (16.0%), medullary (8.9%), anaplastic (17.9%) TCDM histological variants. Overall 1‐, 5‐, and 10‐year DSS rates were 72.0%, 56.8%, and 43.8%, respectively. Anaplastic and medullary variants had the worst 10‐year DSS (0% and 25.5%, respectively). Patients who underwent surgical resection only and surgical resection with radiation were 49% and 59% less likely to die, respectively. Treatment, age, histology, T staging, relationship status, and metastasis site were determined to be significant predictors of survival. Conclusions Surgical resection with radiation was found to be a significant predictor of survival after applying the Bonferroni correction for all thyroid cancer variants except medullary. To increase survival, surgical intervention should be recommended in patients who are deemed to be medically tolerant of surgery. Level of Evidence 4 Laryngoscope, 131:1026–1034, 2021

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Section: Discussionmentioning

confidence: 69%

The Benefit of Primary Tumor Surgical Resection in Distant Metastatic Carcinomas of the Thyroid

et al. 2020

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“…[3][4][5][6][7][8][9][10][11][12][13][14][15][16] However, to our knowledge, few published data have shown any significant survival benefit from multimodal therapy.…”

Section: Discussionmentioning

confidence: 99%

“…The evidence that supports such an approach, however, is based on single-institution studies of select groups of patients. 5,7,9,10,13,16,[22][23][24][25][26] Our current study of the population-based SEER data demonstrates that patients Ͻ 60 years old who have intrathyroidal ATC have a better prognosis compared with older patients who have distant metastasis. Surgical resection with external beam radiation in patients with regional and distant ATC was associated with lower cause-specific cancer mortality.…”

Section: Discussionmentioning

confidence: 99%

Anaplastic thyroid carcinoma

Kebebew

Greenspan

Clark

et al. 2005

Cancer

532

183

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BACKGROUNDAnaplastic thyroid carcinoma (ATC) is rare but is one of the most aggressive human malignancies. Several prognostic factors have been observed in patients with ATC, and some experts advocate aggressive multimodal therapy in selected patients. However, it is unclear whether such an approach significantly improves survival. The authors analyzed prognostic factors and treatment outcomes in patients with ATC reported in the National Cancer Institute's Surveillance, Epidemiology, and End Results data base.METHODSThe cohort consisted of 516 patients with ATC reported to 12 population‐based cancer registries between 1973 and 2000. Demographic, pathologic, and treatment data were used for univariate and multivariate survival analyses.RESULTSThe mean patient age at diagnosis was 71.3 years, and there were 171 men and 345 women. Eight percent of patients had intrathyroidal tumors, 38% had extrathyroidal tumors and/or lymph node invasion, and 43% of patients had distant metastasis. The average tumor size was 6.4 cm (range, 1–15 cm). Sixty‐four percent of patients underwent surgical resection of their primary tumor, and 63% received external beam radiotherapy. The overall cause‐specific mortality rate was 68.4% at 6 months and 80.7% at 12 months. Univariate analysis showed that age < 60 years, female gender, intrathyroidal tumor, external beam radiotherapy, surgical resection, and combined surgical resection of tumor and radiotherapy were associated with a lower cause‐specific mortality. On multivariate analysis, only age < 60 years, an intrathyroidal tumor, and the combined use of surgical and external beam radiation therapy were identified as independent predictors of lower cause‐specific mortality.CONCLUSIONSAlthough most patients with ATC had an extremely poor prognosis, patients < 60 years old with intrathyroidal tumors survived longer. Surgical resection with external beam radiotherapy for ATC was associated with lower cause‐specific mortality. Cancer 2005. © 2005 American Cancer Society.

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