A combined microRNA-based targeted therapeutic approach to eradicate glioblastoma stem-like cells

Abstract

Release, 238 . pp. 43 57. ISSN 0168 3659 It is advisable to refer to the publisher's version if you intend to cite from the work.http://dx.doi.org/10. 1016/j.jconrel.2016.07.032 For more information about UCLan's research in this area go to http://www.uclan.ac.uk/researchgroups/ and search for <name of research Group>. This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. A C C E P T E D M A N U S C R I P T ACCEPTED MANUSCRIPT

Retracted - miR-423-5p knockdown enhances the sensitivity of glioma stem cells to apigenin through the mitochondrial pathway

“…Morgado et al 2 showed that miR-145 regulates neural stem cell differentiation through the Sox2-Lin28/let-7 signaling pathway and that miR-145-mediated modulation of the Sox2-Lin28/let-7 network is crucial for neurogenesis progression. Zheng et al 3 reported that overexpression of miR-186 inhibits the proliferation, migration, and invasion of GSCs and promotes apoptosis, and Esposito et al 4 found that combining miR-137 and anti-miR-10b could prevent GSC expansion. Recently, the "Pharmaco-miR" concept has been put forth through miRNA pharmacogenomics, which is defined as the study of miRNAs and polymorphisms affecting miRNA function to predict drug behavior and improve drug efficacy.…”

Cancer‐Targeting Nanoparticles for Combinatorial Nucleic Acid Delivery

“…This minor population of glioblastoma cells has been associated with tumor reoccurrence and drug resistance. Using pooled miRNAs to revert the stem‐like traits in these cells has proven successful in inhibiting growth, neurosphere formation, and shrinking orthotopic xenografts in mouse glioblastoma models . Therefore, particular combinations of nucleic acids can target certain phenotypes associated with aggressive or reoccurring disease.…”

Drug resistance‐related microRNAs in osteosarcoma: Translating basic evidence into therapeutic strategies

“…MiRNAs have gained increasing attention, and their antagonists or mimics have been designed in cancer therapy to reduce or elevate their previous levels, respectively. 146,147 On one hand, it's acknowledged that a single miRNA simultaneously targets several mRNAs implicated in several signal pathways, which brings great benefits to refractory cancers with genomic heterogeneity. On the other hand, a mRNA can be modulated by multiple miRNAs, implying a therapeutic strategy of applying different miRNA antagonists or mimics to effectively affect the specific target mRNA.…”