Retracted - miR-423-5p knockdown enhances the sensitivity of glioma stem cells to apigenin through the mitochondrial pathway

Wan, Yi; Fei, Xifeng; Wang, Zhimin; Jiang, Dazong; Chen, Hanchun; Wang, Mian; Zhou, Shijun

doi:10.1177/1010428317695526

Cited by 25 publications

(21 citation statements)

References 26 publications

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“…Furthermore, in pancreatic cancer, miR-423-5p was either downregulated or upregulated with a significant inter-individual variation ( 28 ). However, miR-423-5p was demonstrated to be overexpressed in glioma tissues and corresponding glioma stem cells ( 29 ). In the present study, the ovarian tissue and plasma miRNA-423-5p levels in ovarian cancer patients were detected by RT-qPCR, and patients with ovarian endometriosis served as control subjects.…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, miR-423-5p expression enhanced glioma cell proliferation, angiogenesis and invasion via targeting inhibitor of growth family member 4 and activating important signaling molecules, including AKT and extracellular signal-regulated kinase 1/2 ( 31 ). In another study, miR-423-5p knockdown notably enhanced the inhibitory effect of apigenin on the proliferation of glioma stem cells and the promotion of their apoptosis through the mitochondrial pathway ( 29 ). However, hepatocellular cancer cells transfected with miR-423-5p exhibited an increase in the S-phase population of the cell cycle, paralleled by a similar-size increase in autophagic cells ( 21 ).…”

Section: Discussionmentioning

confidence: 99%

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miR‑423‑5p serves as a diagnostic indicator and inhibits the proliferation and invasion of ovarian cancer

et al. 2018

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MicroRNA (miR)-423-5p is a potential target for the diagnosis and therapy of heart failure and cancer. The present study aimed to investigate the expression and role of miR-423-5p in ovarian cancer. miR-423-5p expression in ovarian tissues and plasma collected from ovarian cancer patients and healthy volunteers was analyzed by polymerase chain reaction analysis. In addition, a cell proliferation assay, clonogenic assay and Matrigel-based assay were performed to evaluate the role of miR-423-5p in ovarian cancer cells. The results demonstrated that miR-423-5p was downregulated in ovarian cancer tissues and plasma from ovarian cancer patients, compared with healthy individuals. Of note, miR-423-5p expression in ovarian tissues and plasma was demonstrated to be inversely correlated with ovarian cancer progression. Transfection with miR-423-5p efficiently increased miR-423-5p expression in A2780-s and A2780-cp cells, which had low miR-423-5p expression. Ectopic overexpression of miR-423-5p reduced cell proliferation, colony formation and invasion of ovarian cancer cells. In conclusion, the present study indicated that miR-423-5p may serve as a diagnostic indicator and functions as a tumor suppressor in ovarian cancer.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

miR‑423‑5p serves as a diagnostic indicator and inhibits the proliferation and invasion of ovarian cancer

et al. 2018

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“…Furthermore, our report is the first to identify the downregulation of miR-423-5p in the testis in response to scrotal hyperthermia. Previously, Wan et al reported that miR-423-5p knockdown correlated with reduced proliferation and increased mitochondria-dependent apoptosis among glioma stem cells [ 28 ]. Other studies found that miR-423-5p regulates gastric cancer cell proliferation and invasion [ 29 ] and promotes hepatocarcinoma cell autophagy [ 30 ].…”

Section: Discussionmentioning

confidence: 99%

Next-generation sequencing-based microRNA profiling of mice testis subjected to transient heat stress

Rao

Zeng

et al. 2017

Oncotarget

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This study aimed to investigate the role of microRNA (miRNA) in heat stress-induced spermatogenic impairment. Testes from 15 adult ICR mice subjected to testicular hyperthermia at 43°C for 30 min and from 15 control mice were collected and pooled into 3 samples. Isolated RNA from these samples was subjected to small RNA high-throughput sequencing, and differentially expressed miRNAs were identified and validated using RT-PCR. The identified miRNAs were further subjected to Gene Ontology and KEGG analyses, which revealed significant enrichment for pathways potentially involved in heat stress-induced spermatogenic impairment. Additionally, a correlation analysis of the relative levels of validated miRNAs with germ cell apoptosis was performed. Of the 11 miRNAs identified as differentially expressed, 8 were validated as consistent with sequencing data. Further analyses suggested that the target genes of those miRNAs were involved in various pathways (e.g., ribosomal, HIF-1, MAPK) that may be critical to heat stress-induced testicular damage. Some identified miRNAs, including miR-449a-3p, miR-92a-1-5p, miR-423-3p, and miR-128-3p, correlated closely with germ cell apoptosis. The study results reveal a detailed miRNA profile of heat stress-induced testicular damage and highlight new and potentially important candidate targets in the process of male infertility.

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“…miR-423-5p is overexpressed in glioblastomas and contributes to glioma stem cells. The downregulation of miR-423-5p enhances apigenin-induced cell apoptosis in glioma stem cells with a shift in the Bax/Bcl-2 ratio, an increased cytochrome c level, Apaf-1 induction and caspase-3 activation [ 126 ]. In contrast, in malignant neuroblastoma SK-N-DZ and SK-N-BE2 cells, miR-138 overexpression significantly enhanced apigenin-induced cell apoptosis and decreased cell viability and colony formation capability in vitro and effectively suppressed tumor growth in vivo [ 127 ].…”

Section: Combination Therapy For Apigeninmentioning

confidence: 99%

Apigenin in cancer therapy: anti-cancer effects and mechanisms of action

et al. 2017

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Apigenin is a common dietary flavonoid that is abundantly present in many fruits, vegetables and Chinese medicinal herbs and serves multiple physiological functions, such as strong anti-inflammatory, antioxidant, antibacterial and antiviral activities and blood pressure reduction. Therefore, apigenin has been used as a traditional medicine for centuries. Recently, apigenin has been widely investigated for its anti-cancer activities and low toxicity. Apigenin was reported to suppress various human cancers in vitro and in vivo by multiple biological effects, such as triggering cell apoptosis and autophagy, inducing cell cycle arrest, suppressing cell migration and invasion, and stimulating an immune response. In this review, we focus on the most recent advances in the anti-cancer effects of apigenin and their underlying mechanisms, and we summarize the signaling pathways modulated by apigenin, including the PI3K/AKT, MAPK/ERK, JAK/STAT, NF-κB and Wnt/β-catenin pathways. We also discuss combinatorial strategies to enhance the anti-cancer effect of apigenin on various cancers and its use as an adjuvant chemotherapeutic agent to overcome cancer drug resistance or to alleviate other adverse effects of chemotherapy. The functions of apigenin against cancer stem cells are also summarized and discussed. These data demonstrate that apigenin is a promising reagent for cancer therapy. Apigenin appears to have the potential to be developed either as a dietary supplement or as an adjuvant chemotherapeutic agent for cancer therapy.

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Retracted - miR-423-5p knockdown enhances the sensitivity of glioma stem cells to apigenin through the mitochondrial pathway

Abstract: -423-5p knockdown enhances the sensitivity of glioma stem cells to apigenin through the mitochondrial pathway.

Cited by 25 publications

References 26 publications

miR‑423‑5p serves as a diagnostic indicator and inhibits the proliferation and invasion of ovarian cancer

miR‑423‑5p serves as a diagnostic indicator and inhibits the proliferation and invasion of ovarian cancer

Next-generation sequencing-based microRNA profiling of mice testis subjected to transient heat stress

Apigenin in cancer therapy: anti-cancer effects and mechanisms of action

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