A Combinatorial Code for Pattern Formation in Drosophila Oogenesis

Yakoby, Nir; Bristow, Christopher A.; Gong, Danielle; Schafer, Xenia; Lembong, Jessica; Zartman, Jeremiah J.; Halfon, Marc S.; Schüpbach, Trudi; Shvartsman, Stanislav Y.

doi:10.1016/j.devcel.2008.09.008

Cited by 67 publications

(89 citation statements)

References 78 publications

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“…1D, Inset). In contrast, gene expression patterns within postmitotic ovarian follicle cells are exquisitely regulated by intercellular signaling (17) but show no evident relationship to cell lineage.…”

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confidence: 91%

Epigenetic stability increases extensively during Drosophila follicle stem cell differentiation

Skora

Spradling

2010

Proc. Natl. Acad. Sci. U.S.A.

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Stem and embryonic cells facilitate programming toward multiple daughter cell fates, whereas differentiated cells resist reprogramming and oncogenic transformation. How alterations in the chromatin-based machinery of epigenetic inheritance contribute to these differences remains poorly known. We observed random, heritable changes in GAL4/UAS transgene programming during Drosophila ovarian follicle stem cell differentiation and used them to measure the stage-specific epigenetic stability of gene programming. The frequency of GAL4/UAS reprogramming declines more than 100-fold over the nine divisions comprising this stem cell lineage. Stabilization acts in cis, suggesting that it is chromatin-based, and correlates with increased S phase length. Our results suggest that stem/early progenitor cells cannot accurately transmit nongenetic information to their progeny; full epigenetic competence is acquired only gradually during early differentiation. Modulating epigenetic inheritance may be a critical process controlling transitions between the pleuripotent and differentiated states.epigenetic inheritance | pleuripotency | cell lineage | reprogramming

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confidence: 91%

Epigenetic stability increases extensively during Drosophila follicle stem cell differentiation

Skora

Spradling

2010

Proc. Natl. Acad. Sci. U.S.A.

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“…Their specification is initiated when the TGFα-like ligand Gurken (GRK) is secreted from the dorsal anterior cortex of the oocyte and signals through EGF receptors on the neighboring follicle cells (Chang et al, 2008;Neuman-Silberberg and Schupbach, 1993;Neuman-Silberberg and Schupbach, 1994;Queenan et al, 1997). The resulting gradient of EGFR activation controls a number of transcription factors, signaling molecules and effector genes required for eggshell morphogenesis (Cavaliere et al, 2008;Dobens and Raftery, 2000;Wu et al, 2008;Yakoby et al, 2008a). Several other pathways, including Decapentaplegic (DPP) and Notch, are also involved in this process (Deng and Bownes, 1997;Twombly et al, 1996;Ward et al, 2006), but their role is secondary to that of the EGFR pathway as the dorsal eggshell structures are completely abolished in the absence of GRK (Schupbach, 1987).…”

Section: Introductionmentioning

confidence: 99%

Feedback control of the EGFR signaling gradient: superposition of domain-splitting events inDrosophilaoogenesis

et al. 2009

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The morphogenesis of structures with repeated functional units, such as body segments and appendages, depends on multi-domain patterns of cell signaling and gene expression. We demonstrate that during Drosophila oogenesis, the two-domain expression pattern of Broad, a transcription factor essential for the formation of the two respiratory eggshell appendages, is established by a single gradient of EGFR activation that induces both Broad and Pointed, which mediates repression of Broad. Two negativefeedback loops provided by the intracellular inhibitors of EGFR signaling, Kekkon-1 and Sprouty, control the number and position of Broad-expressing cells and in this way influence eggshell morphology. Later in oogenesis, the gradient of EGFR activation is split into two smaller domains in a process that depends on Argos, a secreted antagonist of EGFR signaling. In contrast to the previously proposed model of eggshell patterning, we show that the two-domain pattern of EGFR signaling is not essential for specifying the number of appendages. Thus, the processes that define the two-domain patterns of Broad and EGFR activation are distinct; their actions are separated in time and have different effects on eggshell morphology.

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“…miR-318 is uniformly expressed in somatically derived follicle cells during late oogenesis. It has been shown that spatial gene expression patterns in the follicle cells follow a simple combinatorial code based on six basic shapes, including the uniform pattern (Yakoby et al 2008;Cheung et al 2011). The uniform expression pattern of miR-318 in the follicle cells may reflect its function as a uniform repressor.…”

Section: Discussionmentioning

confidence: 99%

Regulation of Pattern Formation and Gene Amplification During Drosophila Oogenesis by the miR-318 microRNA

Deng

Guo

et al. 2015

Genetics

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Pattern formation during epithelial development requires the coordination of multiple signaling pathways. Here, we investigate the functions of an ovary-enriched miRNA, miR-318, in epithelial development during Drosophila oogenesis. mir-318 maternal loss-of-function mutants were female-sterile and laid eggs with abnormal morphology. Removal of mir-318 disrupted the dorsal-anterior follicle cell patterning, resulting in abnormal dorsal appendages. mir-318 mutant females also produced thin and fragile eggshells due to impaired chorion gene amplification. We provide evidence that the ecdysone signaling pathway activates expression of miR-318 and that miR-318 cooperates with Tramtrack69 to control the switch from endocycling to chorion gene amplification during differentiation of the follicular epithelium. The multiple functions of miR-318 in oogenesis illustrate the importance of miRNAs in maintaining cell fate and in promoting the developmental transition in the female follicular epithelium.

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A Combinatorial Code for Pattern Formation in Drosophila Oogenesis

Cited by 67 publications

References 78 publications

Epigenetic stability increases extensively during Drosophila follicle stem cell differentiation

Epigenetic stability increases extensively during Drosophila follicle stem cell differentiation

Feedback control of the EGFR signaling gradient: superposition of domain-splitting events inDrosophilaoogenesis

Regulation of Pattern Formation and Gene Amplification During Drosophila Oogenesis by the miR-318 microRNA

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