A combination of prebiotic short- and long-chain inulin-type fructans enhances calcium absorption and bone mineralization in young adolescents

Abstract

Daily consumption of a combination of prebiotic short- and long-chain inulin-type fructans significantly increases calcium absorption and enhances bone mineralization during pubertal growth. Effects of dietary factors on calcium absorption may be modulated by genetic factors, including specific vitamin D receptor gene polymorphisms.

Osteoimmunology: from mice to humans

“…59 A previous study demonstrated that a mixture of short-and long-chain inulin-type fructans, given as prebiotics during adolescence as oral supplements for a 1-year period, increases bone mineralization and calcium absorption. 60 A possible explanation of the effect of dietary or prebiotic fiber on bone metabolism is the effect of the fiber on calcium absorption; the microbiota ferments the fiber to short-chain fatty acids (SCFAs), reducing the gut pH, thus reducing the formation of calcium phosphates and increasing the calcium absorption favoring bone. In the studies on the effect of prebiotics calcium absorption was investigated, whereas immune phenotype and inflammation were not.…”

Improvement of Bone-Sparing Effect of Soy Isoflavones by Pre- and Probiotics in Postmenopausal women

“…Of course, a concomitant trend towards an increase in mineral bioavailability and oestrogen mimetic effect cannot be ruled out (Scholtz-Ahrens et al 2001). Indeed, according to the data published by Abrams et al (2005), a mixture of chicory long-chain inulin and oligofructose is able to increase calcium absorption in volunteers and to impact markers of bone turnover.…”

Frutanos do tipo inulina e aumento da absorção de cálcio: uma revisão sistemática

“…Os estudos foram desenvolvidos em países europeus (Holanda 10,11 e França 12 ) e nos Estados Unidos da América [13][14][15][16] , com os protocolos experimentais aprovados pelos Comitês de Ética em Pesquisa das respectivas instituições. Os participantes e/ou seus responsáveis legais foram esclarecidos a respeito dos objetivos e procedimentos adotados e consentiram em participar dos estudos.…”

“…11 avaliaram somente meninos, Griffin et al 13,14 recrutaram apenas meninas pré-púberes e púberes (com idade próxima à primeira menarca), e Abrams et al 15 selecionaram meninos e meninas pré-púberes.…”

“…Para tanto, os autores utilizaram dados previamente publicados na literatura e consideraram um poder de 90% para detectar Griffin et al 13 Griffin et al 14 Abrams et al 15 Rev. Nutr., Campinas, 25(1):147-159, jan./fev., 2012 Revista de Nutrição diferenças de 5% na taxa de absorção de cálcio entre os grupos; dessa forma no estudo de van den Heuvel et al…”