A combination of ketogenic diet and voluntary exercise ameliorates anxiety and depression-like behaviors in Balb/c mice

Gümüş, Hikmet; Ilgin, Rabia; Koç, Başar; Yüksel, Oğuz; Kızıldağ, Servet; Güvendi, Güven; Karakiliç, Aslı; Kandiş, Sevim; Hoşgörler, Ferda; Ateş, Mehmet; Alaçam, Hasan; Uysal, Nazan

doi:10.1016/j.neulet.2021.136443

Cited by 12 publications

(5 citation statements)

References 43 publications

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“…An in vivo study investigated the impacts of KD intervention and routine voluntary exercise on anxiety and depressive behavior in Balb/c mice [ 50 ]. Both anxiety and depressive symptoms were reduced in KD-exercised mice.…”

Section: Resultsmentioning

confidence: 99%

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The Relationship of Ketogenic Diet with Neurodegenerative and Psychiatric Diseases: A Scoping Review from Basic Research to Clinical Practice

et al. 2023

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Background: The ketogenic diet (KD) has become widespread for the therapy of epileptic pathology in childhood and adulthood. In the last few decades, the current re-emergence of its popularity has focused on the treatment of obesity and diabetes mellitus. KD also exerts anti-inflammatory and neuroprotective properties, which could be utilized for the therapy of neurodegenerative and psychiatric disorders. Purpose: This is a thorough, scoping review that aims to summarize and scrutinize the currently available basic research performed in in vitro and in vivo settings, as well as the clinical evidence of the potential beneficial effects of KD against neurodegenerative and psychiatric diseases. This review was conducted to systematically map the research performed in this area as well as identify gaps in knowledge. Methods: We thoroughly explored the most accurate scientific web databases, e.g., PubMed, Scopus, Web of Science, and Google Scholar, to obtain the most recent in vitro and in vivo data from animal studies as well as clinical human surveys from the last twenty years, applying effective and characteristic keywords. Results: Basic research has revealed multiple molecular mechanisms through which KD can exert neuroprotective effects, such as neuroinflammation inhibition, decreased reactive oxygen species (ROS) production, decreased amyloid plaque deposition and microglial activation, protection in dopaminergic neurons, tau hyper-phosphorylation suppression, stimulating mitochondrial biogenesis, enhancing gut microbial diversity, restoration of histone acetylation, and neuron repair promotion. On the other hand, clinical evidence remains scarce. Most existing clinical studies are modest, frequently uncontrolled, and merely assess the short-term impacts of KD. Moreover, several clinical studies had large dropout rates and a considerable lack of compliance assessment, as well as an increased level of heterogeneity in the study design and methodology. Conclusions: KD can exert substantial neuroprotective effects via multiple molecular mechanisms in various neurodegenerative and psychiatric pathological states. Large, long-term, randomized, double-blind, controlled clinical trials with a prospective design are strongly recommended to delineate whether KD may attenuate or even treat neurodegenerative and psychiatric disease development, progression, and symptomatology.

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Section: Resultsmentioning

confidence: 99%

“…Both anxiety and depressive symptoms were reduced in KD-exercised mice. This decrease in anxiety and depressive behavior caused by KD and routine voluntary exercise could be related to enhanced BHBA amounts, reduced LDL/HDL fraction, and insulin or glucose concentrations [ 50 ].…”

Section: Resultsmentioning

confidence: 99%

The Relationship of Ketogenic Diet with Neurodegenerative and Psychiatric Diseases: A Scoping Review from Basic Research to Clinical Practice

et al. 2023

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“…After the test, each animal was introduced into a box containing dry towel paper under heated lighting. During the analysis of the videos, the immobility time was recorded, which has been broadly used to identify depressive-like behaviors in studies involving FST and rodents ( Holanda et al, 2022 , Gumus et al, 2022 , Sofidiya et al, 2022 ).…”

Section: Methodsmentioning

confidence: 99%

Shedding light on the toxicity of SARS-CoV-2-derived peptide in non-target COVID-19 organisms: A study involving inbred and outbred mice

et al. 2022

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“…A preclinical study found that a 6 weeks program of the KD and exercise can lead to a decrease in anxious and depressive behaviors ( 141 ). A KD comprised of 81% fat, 16% protein, and 1% carbohydrate compared to a control diet of 13% fat, 25% protein, and 62% carbohydrate was provided ad libitum to a series of mice divided into four test groups (KD + Exercise, KD, Exercise, Control).…”

Section: Anxiety Disordersmentioning

confidence: 99%

Exploring the role of ketone bodies in the diagnosis and treatment of psychiatric disorders

Omori¹,

Malys

Woo³

et al. 2023

Front. Psychiatry

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In recent times, advances in the field of metabolomics have shed greater light on the role of metabolic disturbances in neuropsychiatric conditions. The following review explores the role of ketone bodies and ketosis in both the diagnosis and treatment of three major psychiatric disorders: major depressive disorder, anxiety disorders, and schizophrenia. Distinction is made between the potential therapeutic effects of the ketogenic diet and exogenous ketone preparations, as exogenous ketones in particular offer a standardized, reproducible manner for inducing ketosis. Compelling associations between symptoms of mental distress and dysregulation in central nervous system ketone metabolism have been demonstrated in preclinical studies with putative neuroprotective effects of ketone bodies being elucidated, including effects on inflammasomes and the promotion of neurogenesis in the central nervous system. Despite emerging pre-clinical data, clinical research on ketone body effectiveness as a treatment option for psychiatric disorders remains lacking. This gap in understanding warrants further investigating, especially considering that safe and acceptable ways of inducing ketosis are readily available.

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A combination of ketogenic diet and voluntary exercise ameliorates anxiety and depression-like behaviors in Balb/c mice

Cited by 12 publications

References 43 publications

The Relationship of Ketogenic Diet with Neurodegenerative and Psychiatric Diseases: A Scoping Review from Basic Research to Clinical Practice

The Relationship of Ketogenic Diet with Neurodegenerative and Psychiatric Diseases: A Scoping Review from Basic Research to Clinical Practice

Shedding light on the toxicity of SARS-CoV-2-derived peptide in non-target COVID-19 organisms: A study involving inbred and outbred mice

Exploring the role of ketone bodies in the diagnosis and treatment of psychiatric disorders

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