Shedding light on the toxicity of SARS-CoV-2-derived peptide in non-target COVID-19 organisms: A study involving inbred and outbred mice

Luz, Thiarlen Marinho da; Araújo, Amanda Pereira da Costa; Rezende, Fernanda Neves Estrêla; Silva, Abner Marcelino; Charlie-Silva, Ives; Braz, Helyson Lucas Bezerra; Rahman, Md. Mostafizur; Barceló, Damià; Malafaia, Guilherme

doi:10.1016/j.neuro.2022.03.012

Cited by 9 publications

(1 citation statement)

References 121 publications

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“…The FST involved placing each rat separately in a cylindrical tank (40 cm height, 20 cm diameter) filled with water set at room temperature of 25 °C (Can et al 2012 ; da Luz et al 2022 ; da Silva et al 2018 ) (20 cm depth) for 6 min. Then the rats were then taken out of the water, dried, and returned to their cages.…”

Section: Methodsmentioning

confidence: 99%

Bee venom (Apis mellifera L.) rescues zinc oxide nanoparticles induced neurobehavioral and neurotoxic impact via controlling neurofilament and GAP-43 in rat brain

Eleiwa

Ali

Said

et al. 2023

Environ Sci Pollut Res

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This study investigated the possible beneficial role of the bee venom (BV, Apis mellifera L.) against zinc oxide nanoparticles (ZNPs)-induced neurobehavioral and neurotoxic impacts in rats. Fifty male Sprague Dawley rats were alienated into five groups. Three groups were intraperitoneally injected distilled water (C 28D group), ZNPs (100 mg/kg b.wt) (ZNPs group), or ZNPs (100 mg/kg.wt) and BV (1 mg/ kg.bwt) (ZNPs + BV group) for 28 days. One group was intraperitoneally injected with 1 mL of distilled water for 56 days (C 56D group). The last group was intraperitoneally injected with ZNPs for 28 days, then BV for another 28 days at the same earlier doses and duration (ZNPs/BV group). Depression, anxiety, locomotor activity, spatial learning, and memory were evaluated using the forced swimming test, elevated plus maze, open field test, and Morris water maze test, respectively. The brain contents of dopamine, serotonin, total antioxidant capacity (TAC), malondialdehyde (MDA), and Zn were estimated. The histopathological changes and immunoexpressions of neurofilament and GAP-43 protein in the brain tissues were followed. The results displayed that BV significantly decreased the ZNPs-induced depression, anxiety, memory impairment, and spatial learning disorders. Moreover, the ZNPs-induced increment in serotonin and dopamine levels and Zn content was significantly suppressed by BV. Besides, BV significantly restored the depleted TAC but minimized the augmented MDA brain content associated with ZNPs exposure. Likewise, the neurodegenerative changes induced by ZNPs were significantly abolished by BV. Also, the increased neurofilament and GAP-43 immunoexpression due to ZNPs exposure were alleviated with BV. Of note, BV achieved better results in the ZNPs + BV group than in the ZNPs/BV group. Conclusively, these results demonstrated that BV could be employed as a biologically effective therapy to mitigate the neurotoxic and neurobehavioral effects of ZNPs, particularly when used during ZNPs exposure.

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Section: Methodsmentioning

confidence: 99%