A combination of isolated phytochemicals and botanical extracts lowers diastolic blood pressure in a randomized controlled trial of hypertensive subjects

Abstract

Our clinical and in vitro data support the theory that this combination of polyphenols reduced diastolic pressure by potentiating eNOS activation and nitric oxide production. Such supplements may have clinical relevance as stand-alone or adjunct therapy to help reduce BP.

Resveratrol and Related Stilbenoids, Nutraceutical/Dietary Complements with Health‐Promoting Actions: Industrial Production, Safety, and the Search for Mode of Action

“…Usually, one given compound is assayed for one disease or for two/three closely related diseases. In the case of RSV, results from clinical trials have been reported for menopause (Chow et al., ; Evans, Howe, & Wong, ; Yoshino et al., ; Zern et al., ) and for an incredibly high number of ailments: ulcerative colitis (Samsami‐kor, Daryani, Asl, & Hekmatdoost, ), lung affections/infections (Culpitt et al., ; Miraglia Del Giudice et al., ; Varricchio et al., ), allergic rhinitis (Miraglia Del Giudice et al., ), liver diseases (Chachay et al., ; Faghihzadeh, Adibi, & Hekmatdoost, ; Faghihzadeh, Adibi, Rafiei, & Hekmatdoost, ; Heebøll et al., ), chronic kidney disease (Migliori et al., ), benign prostate hyperplasia (Kjaer et al., ), schizophrenia (Zortea et al., ), memory performance/cognition/brain glucose consumption/AD (Cuzzola et al., ; Kennedy et al., ; Turner et al., ; Wightman et al., ; Witte, Kerti, Margulies, & Flöel, ), Friedreich ataxia (Yiu et al., ), facial nerve injury (Tanyeri, Celik, Erbas, Oltulu, & Yilmaz Dilsiz, ), diabetes/metabolic syndrome/insulin resistance (Bhatt, Thomas, & Nanjan, ; Brasnyó et al., ; Chen et al., ; Crandall et al., ; Fujitaka et al., ; Goh et al., ; Méndez‐del Villar, González‐Ortiz, Martínez‐Abundis, Pérez‐Rubio, & Lizárraga‐Valdez, ; Olesen et al., ; Skroza et al., ; Thazhath et al., ; Tomé‐Carneiro et al., ), inflammation (Olesen et al., ), facial redness (Ferzli, Patel, Phrsai, & Brody, ), cancer/metastases (Brown et al., ; Chow et al., ; Howells et al., ; Ji et al., ; Patel et al., ; Popat et al., ), cardiovascular diseases/lipoprotein status/obesity (Agarwal et al., ; Amato et al., ; Bakker et al., ; Biesinger et al., ; Cruz, ; Dash, Xiao, Morgantini, Szeto, & Lewis, ; De Groote et al., …”

“…RSV intake by humans results in enhanced production of tumor necrosis factor alpha by monocytes activated upon bacterial infection (Gualdoni et al., ). The effect of the molecule in endothelial cells may be related to nitric oxide production, as deduced from a study using a mixture of plant extracts and RSV (Biesinger et al., ). RSV also promotes changes in the hypermethylation pattern of breast cancer‐related genes in mammary ductoscopy specimens (Zhu et al., ).…”

Health Benefits of Dietary Whole Grains: An Umbrella Review of Meta-analyses

“…10,11 Finally, whole grain phytochemical constituents can influence the vascular endothelium directly by promoting vasodilation, which leads to a reduction in blood pressure. 33 A reduction in blood pressure could significantly reduce the incidence of stroke, and this was identified in both meta-analyses that reported a reduction in RR of between 8% and 14%; however, only 1 of the 2 meta-analyses was statistically significant. 15 Compared with populations with the lowest intakes of dietary whole grains, the populations with the highest intakes observed significant reductions in the incidence of colorectal cancer by 21%, pancreatic cancer by 24% to 30%, and gastric cancer by 43%.…”

Protective Activity of Resveratrol in Cardio- and Cerebrovascular Diseases

“…In fact, a randomized, crossover, double-blind, single-dose, placebo-uncontrolled clinical trial with a single ingestion of 30, 90, 270 mg of synthetic RSV or placebo at weekly intervals, with analyses performed 1 h after consumption on nine healthy over-weighted/obese men or postmenopausal women with mildly elevated blood pressure, showed an acute RSV effect on FMD, which improved by 65% after consumption of 30 or 90 mg RSV and by 88% with 270 mg [87]. Another double-blind, randomized, placebo-controlled, crossover clinical trial on 18 patients with 330 mg of grape seeds and skin, 100 mg of green tea, 60 mg of RSV, 60 mg blend of quercetin and ginkgo biloba and bilberry on a 28 day basis showed a significant reduction in diastolic blood pressure [88]. RSV's main purpose has been studied by this clinical crossover, randomized, doubleblind, placebo-controlled, single-center trial, which confirmed that RSV for 4 weeks lowers BP in prehypertensive and stage 1-hypertensive patients [89].…”