A combination of GDNF and hUCMSC transplantation loaded on SF/AGs composite scaffolds for spinal cord injury repair

Jiao, Genlong; Lou, Guofeng; Mo, Yunfei; Pan, Yongqin; Zhang, Ziyong; Guo, Rui; Li, Zhizhong

doi:10.1016/j.msec.2016.12.017

Cited by 33 publications

(25 citation statements)

References 46 publications

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“…38,71,73–77 These physiologic effects can additionally be accentuated with the co-administration of various growth factors, to include brain-derived neutrophic factor, 71 glial cell-line neutrophic factor, 72 and neurotrophin-3. 78 …”

Section: Methodsmentioning

confidence: 99%

The Science and Clinical Applications of Placental Tissues in Spine Surgery

Shaw

Parada

Gloystein

et al. 2018

Global Spine Journal

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Study Design:Narrative literature review.Objectives:Placental tissue, amniotic/chorionic membrane, and umbilical cord have seen a recent expansion in their clinical application in various fields of surgery. It is important for practicing surgeons to know the underlying science, especially as it relates to spine surgery, to understand the rationale and clinical indication, if any, for their usage.Methods:A literature search was performed using PubMed and MEDLINE databases to identify studies reporting the application of placental tissues as it relates to the practicing spine surgeon. Four areas of interest were identified and a comprehensive review was performed of available literature.Results:Clinical application of placental tissue holds promise with regard to treatment of intervertebral disc pathology, preventing epidural fibrosis, spinal dysraphism closure, and spinal cord injury; however, there is an overall paucity of high-quality evidence. As such, evidence-based guidelines for its clinical application are currently unavailable.Conclusions:There is no high-level clinical evidence to support the application of placental tissue for spinal surgery, although it does hold promise for several areas of interest for the practicing spine surgeon. High-quality research is needed to define the clinical effectiveness and indications of placental tissue as it relates to spine surgery.

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Section: Methodsmentioning

confidence: 99%

The Science and Clinical Applications of Placental Tissues in Spine Surgery

Shaw

Parada

Gloystein

et al. 2018

Global Spine Journal

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“…Jiao et al [31] employed a silk fibroin/alginate GDNF scaffold seeded with human umbilical cord mesenchymal stem cells (hUCMSCs) for a thoracic contusion injury in a rat model. The silk fibroin scaffold combined with alginate had a prolonged release of GDNF compared to either scaffold alone.…”

Section: Studies Using Gdnf In Combinational Therapies For Sci Repairmentioning

confidence: 99%

Role of GDNF in Spinal Cord Injury Repair

Walker¹,

Xu²

2018

Preprint

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Following an initial mechanical insult, traumatic spinal cord injury (SCI) induces a secondary wave of injury, resulting in a toxic lesion environment inhibitory to axonal regeneration. This review focuses on the glial cell line-derived neurotrophic factor (GDNF) and its application, also in combination with other factors and cell transplantations, for repairing the injured spinal cord. As recent decades of studies strongly suggest combinational treatment approaches hold the greatest therapeutic potential for the central nervous system (CNS) trauma, future directions of combinational therapies will also be discussed.

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“…Eight-weeks post-implantation, it was observed a more prominent locomotor recovery in the cell + scaffold group compared with the group implanted with the scaffold alone. On the other hand, Jiao and colleagues ( 104 ) compared the regenerative potential ofhUC-MSCs loaded on a specific composite scaffold composed of silk fibroin/alginate and coated with GDNF (SF/AGs/GDNF scaffold) with the SF/AGs/GDNF scaffold group alone in a compressive SCI rat model. Eight weeks after implantation, they found that combining the composite scaffold with hUC-MSCs improved the locomotor recovery after SCI.…”

Section: Combined Approaches Of Mscs and Scaffoldsmentioning

confidence: 99%

The combined strategy of mesenchymal stem cells and tissue-engineered scaffolds for spinal cord injury regeneration

Libro

Bramantı

Mazzon

2017

Experimental and Therapeutic Medicine

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Spinal cord injury (SCI) is a traumatic lesion that can result in the loss of motor or sensory neurons. Stem cell (SC)-based therapies have been demonstrated to promote neuronal regeneration following SCI, by releasing a range of trophic factors that support endogenous repair or by differentiating into neurons, or glial cells in order to replace the damaged cells. However, numerous limitations remain for therapies based on SC transplantion alone, including a low rate of survival/engraftment. Nevertheless, scaffolds are 3-dimentional substrates that have revealed to support cell survival, proliferation and differentiation in vivo, by mimicking a more favorable endogenous microenvironment. A multidisciplinary approach, which combines engineered scaffolds with SCs has been proposed as a promising strategy for encouraging spinal cord regeneration. The present review has focused on the regenerative potential of mesenchymal SCs isolated from different sources and combined with various scaffold types, in preclinical and clinical SCI studies.

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A combination of GDNF and hUCMSC transplantation loaded on SF/AGs composite scaffolds for spinal cord injury repair

Cited by 33 publications

References 46 publications

The Science and Clinical Applications of Placental Tissues in Spine Surgery

The Science and Clinical Applications of Placental Tissues in Spine Surgery

Role of GDNF in Spinal Cord Injury Repair

The combined strategy of mesenchymal stem cells and tissue-engineered scaffolds for spinal cord injury regeneration

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