A Colorimetric Determination of Streptomycin and Dihydrostreptomycin**The author wishes to thank Mr. F. H. Hedger, Mr. T. C. Grenfell, and Dr. J. A. Means for their helpful comments and constructive criticisms of this paper.

Review - Pharmaceuticals and Natural Drugs

“…A correction is made for streptomycin interference when present in excess of 2%; the procedure requires careful control of variables (381). Monastero (256) has reported the colorimetric determination of streptomycin and dihydrostreptomycin which involves a reaction of the streptidine moiety of the molecule; the color reaction is an extension of a test for guanidine. The Voges-Proskauer reaction has also been adapted to the quantitative determination of streptomycin and dihydrostreptomycin (365).…”

Separation of Aureomycin from Terramycin by Countercurrent Distribution and by Paper Chromatography

“…The agents appear to be very similar in certain respects, though there are differences in ultraviolet absorption spectra (S) and in certain functional groups (6,17). Isolated materials may be differentiated in part by the action of concentrated sulfuric acid (11,18); a cherry-red color is formed by Terramycin and a blue color by Aureomycin. The structures of Terramycin (9) and Aureomycin (17,20) have recently been elucidated.…”

The biogenesis of mitochondria, VI. Biochemical basis of the resistance of Saccharomyces cerevisiae toward antibiotics which specifically inhibit mitochondrial protein synthesis.

“…Most experiments were conducted with strain L410 (CAP-S, 0.1; ERY-S, 0.1) and three mutants derived therefrom, L414 (CAP-R, 1.5; ERY-S, 0.1), L411 (CAP-S, 0.1; ERY-R, 8), and L413 (CAP-R, 1.5; ERY-R, 8). CAP and ERY denote chloramphenicol and erythromycin and the suffixes R and S the whole cell resistance or sensitivity to the antibiotics; the number following the suffix is the concentration of antibiotic (mg/ml) in a glycerol growth medium to which the cells are either sensitive or resistant.…”