Review - Pharmaceuticals and Natural Drugs

The unusual behavior of the Gibbs’ reagent versus Nitrofural

“…The Gibbs' reagent has been and is still used as a powerful analytical tool for the qualitative and quantitative analysis of many pharmacopoeial representatives, such as orciprenaline sulfate (2), Cresolum crudum (17,18), vitamins B6 (19) and K (20), theophylline (21), methylthiouracil (22,23), the anesthetic propofol (24)(25)(26), as well as of some antibiotics and opiates (27). The presence both of all aforementioned compounds and many other non-pharmaco-poeial analytes can also be verified using the "Gibbs' spray" (TLC developer).…”

Determination of organic acids and carbonyl compounds

“…Guenther and others (9,10,11) have reviewed the analytical methods for the determination of acidic substances in essential oils and related products. Pifer, Wollish and Schmall (12,13,14), Marsh and Hilty (15) and Ekeblad and Erne (16) have investigated the application of nonaqueous titrimetry to pharmaceutical products. Methods for the de termination of organic acids encountered in clinical chemistry have been reviewed (17).…”