A colorimetric aptasensor for the diagnosis of malaria based on cationic polymers and gold nanoparticles

Diagnosis of communicable diseases using papepr microfluidic platforms

“…Over the past few decades, a variety of paper-based devices have been developed for the diagnosis of malaria parasites [50,51,[54][55][56][57][58][59][60][61][62]]. An automated two-dimensional paper device has been fabricated for the detection of Plasmodium falciparum histidine-rich protein 2 (PfHRP2) [54].…”

A simple and sensitive fluorimetric aptasensor for the ultrasensitive detection of arsenic(III) based on cysteamine stabilized CdTe/ZnS quantum dots aggregation

“…Aptamers are oligonucleotide molecules (ssDNA or RNA) that bind to a specific target such as molecules or metallic ions (Jeon et al, 2013). Aptamers compete to antibodies in both therapeutic and diagnostic applications (Jeon et al, 2013).…”

“…Aptamers compete to antibodies in both therapeutic and diagnostic applications (Jeon et al, 2013). The aptamer-target interaction takes places via hydrogen bonding, electrostatic and Van der Waals forces, or a combination of these interactions between aptamer and its target (Saberian et al, 2012).…”

“…Using of aptamers in the different fields of research has increased in the past few decades because of their advantages such as their simplicity of detection and analysis, specificity to targets and ease of synthesis (Jeon et al, 2013).…”

Aromatic Surfactant as Aggregating Agent for Aptamer-Gold Nanoparticle-Based Detection of Plasmodium Lactate Dehydrogenase

“…Several biomarkers for diagnosis of malaria have been investigated [13] among which Plasmodium-specific lactate dehydrogenase has emerged as a promising biomarker for malaria detection owing to its subtle structural and kinetic differences from the mammalian counterpart, leading to an increased interest in development of sensors that target this enzyme [14][15][16][17][18]. Here, we report a novel ssDNA aptamer developed against Plasmodium falciparum lactate dehydrogenase and its application potential to detect this biomarker through an aromatic cationic surfactant-based assay using gold nanoparticles as the optical sensing platform.…”