A Colony of Specific Pathogen-Free Rats

Bell, Deirdre P.; Elmes, P. C.; Wheeler, Sylvia M.

doi:10.1038/201273a0

Cited by 9 publications

(7 citation statements)

References 1 publication

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“…Complementfixation tests gave low titres (<4) against S. moniliformis, L1 and M. pulmonis. Lung histology was within normal limits according to criteria of normality established by an earlier study (Bell, 1967) and there was no evidence of CRD in any of the lungs ( fig. 1).…”

Section: Methodsmentioning

confidence: 96%

“…Previously cortisone has produced a marked exacerbation of CRD in naturally infected rats (Bell et al, 1964). Since CRD was produced by an inoculum from which S. monilgormis and M. pulmonis could not be cultured, it appears that S. moniliformis and M. pulmonis are merely secondary invaders or possibly commensals.…”

Section: Discussionmentioning

confidence: 99%

“…Animals of this colony were free from CRD ( fig. 1) and all infectious diseases (except pin-worm) that were present in the conventional colony (Bell, 1967(Bell, , 1968. The original stock for both of these colonies was provided by Imperial Chemical Industries Ltd soon after they started an SPF rat colony (Davey, 1959).…”

Section: Ratsmentioning

confidence: 99%

“…FIG into the trachea (Elmes and Bell, 1963). The left lung was stained as for experiments 1 and 2, but analysed in more detail by a method used previously on a large group of SPF and conventional rats of various ages (Bell, 1967). Grading.…”

Section: Bacteriology and Serologymentioning

confidence: 99%

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Effects Of Certain Organisms Associated With Chronic Respiratory Disease On Spf And Conventional Rats

Bell

Elmes

1969

Journal of Medical Microbiology

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Section: Methodsmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

Section: Ratsmentioning

confidence: 99%

Section: Bacteriology and Serologymentioning

confidence: 99%

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Effects Of Certain Organisms Associated With Chronic Respiratory Disease On Spf And Conventional Rats

Bell

Elmes

1969

Journal of Medical Microbiology

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“…For this purpose splenectomy was performed on 13 CD rats and 14 controls (Bell, Elmes & Wheeler, 1964).…”

Section: Methodsmentioning

confidence: 99%

Disease in a Caesarian-Derived Albino Rat Colony and in a Conventional Colony

Bell

1968

Lab Anim

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A small caesarian-derived colony of albino rats was established in 1960 and has been maintained apparently free of specific pathogens by a simple and inexpensive method. The prevalence of disease, parasite infestations and other abnormalities has been compared in the caesarian-derived colony with rats of the same strain kept under conventional conditions. The investigation has shown that rats of the caesarian-derived colony were free from chronic respiratory disease, lice, worms in the urinary bladder, tape-worms, bartonellosis, salmonellosis, labyrinthitis and various minor infections, all of which were prevalent in rats kept under conventional conditions. Animals of both colonies were subject to a low incidence of tumours, which were of various types in the caesarian-derived rats but mainly mammary carcinomas in the controls. A haemorrhagic hepatic disease occurred for a short time in both colonies. The most prevalent congenital abnormality was one associated with hydronephrosis, pyelonephritis and a haemorrhagic renal disease; both colonies had a similar prevalence of these lesions. Occasional cases of hydrocephalus, situs inversus, cleft lip and cleft palate, microphthalmia and absent organs were observed in both colonies. The study has indicated that there are considerable advantages in using caesarian-derived rats in preference to conventional stock in experimental work.

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The effects of chlorine gas on the lungs of rats without spontaneous pulmonary disease

Bell

Elmes

1965

J. Pathol.

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A Colony of Specific Pathogen-Free Rats

Cited by 9 publications

References 1 publication

Effects Of Certain Organisms Associated With Chronic Respiratory Disease On Spf And Conventional Rats

Effects Of Certain Organisms Associated With Chronic Respiratory Disease On Spf And Conventional Rats

Disease in a Caesarian-Derived Albino Rat Colony and in a Conventional Colony

The effects of chlorine gas on the lungs of rats without spontaneous pulmonary disease

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