A collagen I derived matricryptin increases aorta vascular wall remodeling after induced thrombosis in mouse

Pozzo, Caroline Fernanda Sanches Dal; Sielski, Micheli S.; Vidal, Benedicto de Campos; Werneck, Cláudio C.; Vicente, Cristina Pontes

doi:10.1016/j.thromres.2021.11.021

Cited by 3 publications

(3 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Peptide p1158/59 is naturally present in human and mouse infarcted myocardium, and its synthetic counterpart has been shown to promote remodeling of left ventricle tissue and cardiac function in infarcted mouse hearts by mediating scarring and angiogenesis [ 170 , 171 ]. Peptide p1158/59 also potentiated the remodeling of the mouse aorta wall after induced thrombosis [ 172 ]. To our knowledge, p1158/59 has not yet entered clinical trials.…”

Section: Targeting With Collagenmentioning

confidence: 99%

The Versatility of Collagen in Pharmacology: Targeting Collagen, Targeting with Collagen

Revert-Ros,

Ventura,

Prieto-Ruiz

et al. 2024

IJMS

View full text Add to dashboard Cite

Collagen, a versatile family of proteins with 28 members and 44 genes, is pivotal in maintaining tissue integrity and function. It plays a crucial role in physiological processes like wound healing, hemostasis, and pathological conditions such as fibrosis and cancer. Collagen is a target in these processes. Direct methods for collagen modulation include enzymatic breakdown and molecular binding approaches. For instance, Clostridium histolyticum collagenase is effective in treating localized fibrosis. Polypeptides like collagen-binding domains offer promising avenues for tumor-specific immunotherapy and drug delivery. Indirect targeting of collagen involves regulating cellular processes essential for its synthesis and maturation, such as translation regulation and microRNA activity. Enzymes involved in collagen modification, such as prolyl-hydroxylases or lysyl-oxidases, are also indirect therapeutic targets. From another perspective, collagen is also a natural source of drugs. Enzymatic degradation of collagen generates bioactive fragments known as matrikines and matricryptins, which exhibit diverse pharmacological activities. Overall, collagen-derived peptides present significant therapeutic potential beyond tissue repair, offering various strategies for treating fibrosis, cancer, and genetic disorders. Continued research into specific collagen targeting and the application of collagen and its derivatives may lead to the development of novel treatments for a range of pathological conditions.

show abstract

Section: Targeting With Collagenmentioning

confidence: 99%

The Versatility of Collagen in Pharmacology: Targeting Collagen, Targeting with Collagen

Revert-Ros,

Ventura,

Prieto-Ruiz

et al. 2024

IJMS

View full text Add to dashboard Cite

show abstract

“…Type I collagen is one of the most abundant structural matrix proteins, forming a heterotrimer with two α1 chains and one α2 chain, and it is widely distributed throughout the body, including the kidneys. Peptides produced by the degradation of type 1 collagen by MMPs have been reported to be involved in several physiological processes, such as angiogenesis [ 11 ] and matrix remodelling [ 12 ▪▪ ]. Polypeptide fragments found at (and referred to by) their starting amino acid position at p1158/159, produced through cleavage by MMP2 and MMP9 from the C-terminal region of mature type I collagen α1 chain and further degraded by MMP9 into smaller fragments, are thought to act as matrikines [ 11 ].…”

Section: Collagensmentioning

confidence: 99%

“…Studies where the first 15 amino acids of p1158/159 were purified have reported that it promotes wound healing both in fibroblasts and in a mouse model of myocardial infarction by accelerating matrix remodelling and angiogenesis [ 11 ]. This small peptide also improved vascular re-endothelialization, collagen fibre deposition and organization by inducing remodelling of the matrix in a mouse model of vascular injury [ 12 ▪▪ ]. Furthermore, a trimer of C-terminal-derived peptides (propeptide trimer carboxyl-terminal to type I collagen: PICP), which are cleaved and released from the precursor type I procollagen during the formation of type I collagen α1 and α2 chains, have been shown to induce directional migration of vascular endothelial cells in vitro [ 13 ].…”

Section: Collagensmentioning

confidence: 99%

Matrikines in kidney ageing and age-related disease

Eckersley

Yamamura

Lennon

2023

Current Opinion in Nephrology &Amp; Hypertension

View full text Add to dashboard Cite

Purpose of review Matrikines are cell-signalling extracellular matrix fragments and they have attracted recent attention from basic and translational scientists, due to their diverse roles in age-related disease and their potential as therapeutic agents. In kidney, the matrix undergoes remodelling by proteolytic fragmentation, so matrikines are likely to play a substantial, yet understudied, role in ageing and pathogenesis of age-related diseases. Recent findings This review presents an up-to-date description of known matrikines with either a confirmed or highly anticipated role in kidney ageing and disease, including their point of origin, mechanism of cleavage, a summary of known biological actions and the current knowledge which links them to kidney health. We also highlight areas of interest, such as the prospect of matrikine cross-tissue communication, and gaps in knowledge, such as the unexplored signalling potential of many kidney disease-specific matrix fragments. Summary We anticipate that knowledge of specific matrikines, and their roles in controlling processes of kidney pathology, could be leveraged for the development of exciting new future therapies through inhibition or even with their supplementation.

show abstract

Down-regulation of the Smad signaling by circZBTB46 via the Smad2-PDLIM5 axis to inhibit type I collagen expression

Wang

Zhang

et al. 2023

Journal of Geriatric Cardiology

View full text Add to dashboard Cite

A collagen I derived matricryptin increases aorta vascular wall remodeling after induced thrombosis in mouse

Cited by 3 publications

References 51 publications

The Versatility of Collagen in Pharmacology: Targeting Collagen, Targeting with Collagen

The Versatility of Collagen in Pharmacology: Targeting Collagen, Targeting with Collagen

Matrikines in kidney ageing and age-related disease

Down-regulation of the Smad signaling by circZBTB46 via the Smad2-PDLIM5 axis to inhibit type I collagen expression

Contact Info

Product

Resources

About