Background:
In addition to the well known role played on lactation and parturition, Oxytocin (OT) and OT
receptor (OTR) are involved in many other aspects such as the control of maternal and social behavior, the
regulation of the growth of the neocortex, the maintenance of blood supply to the cortex, the stimulation of
limbic olfactory area to mother-infant recognition bond, and the modulation of the autonomic nervous
system via vagal pathway. Moreover, OT and OTR show anti-inflammatory, anti-oxidant, anti-pain, antidiabetic, anti-dyslipidemic and anti-atherogenic effects.
Objective:
The aim of this narrative review is to
summarize the main data coming from the literature dealing with the role of OT and OTR in physiology and
pathologic conditions focusing on the most relevant aspects.
Methods:
Appropriate keywords and MeSH
terms were identified and searched in Pubmed. Finally, references of original articles and reviews were
examined.
Results:
We report the most significant and updated data about the role played by OT and OTR in
physiology and in different clinical context.
Conclusion:
Emerging evidence indicates the involvement of
OT system in several pathophysiological mechanisms influencing brain anatomy, cognition, language, sense
of safety and trust and maternal behavior, with a possible use of exogenous administered OT in the treatment
of specific neuro-psychiatric conditions. Furthermore, it modulates pancreatic β-cell responsiveness and lipid
metabolism leading to possible therapeutic use in diabetic and dyslipidemic patients and for limiting and
even reversing atherosclerotic lesions.