A cMUT probe for ultrasound-guided focused ultrasound targeted therapy

Gross, D.; Coutier, C.; Legros, Mathieu; Bouakaz, Ayache; Certon, Dominique

doi:10.1109/tuffc.2014.006887

Cited by 26 publications

(14 citation statements)

References 46 publications

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“…More precisely, sonoporation and the triggered release of thermosensitive liposomes (TSLs) [28] were targeted. Whereas sonoporation generally requires a relatively low peak negative pressure (PNP), the mild hyperthermia required to reach the melting phase transition temperature of the TSLs is more challenging to generate at 1 MHz: [29] showed that this temperature, typically approximately 42˚C, can be reached at 1 MHz, More detailed information about the design stage, the manufacturing process and the choice of the CMUT geometry are given by [27]. …”

Section: Overview Of the Usgfus Cmut Probementioning

confidence: 99%

“…Therefore, high-end probes including multi-frequency compact arrays are achievable using CMUT technology, which are highly beneficial to the development of breakthrough USgFUS products. The USgFUS CMUT probe we have developed has been previously presented [27]. Contrary to the previous article that was dedicated to the probe description and the very first characterizations of the CMUT arrays, this article is devoted to the in-depth characterization of the therapeutic ultrasonic beam and the assessment of the CMUTs viability for hyperthermia applications.…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of an Ultrasound-Guided Focused Ultrasound CMUT Probe for Targeted Therapy Applications

Gross¹,

Legros

Vince³

et al. 2018

OJAppS

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Capacitive Micromachined Ultrasonic Transducer (CMUT) technology, which has been widely studied in the field of medical imaging, possesses strong design flexibility due to its manufacturing process. Many applications could benefit from this unique feature, especially those that require different operating ultrasonic frequencies. This article reports on the characterization of the therapeutic low-frequency field provided by an ultrasound-guided focused ultrasound CMUT probe that is connected to a custom ultrasonic scanner for hyperthermia applications. The study begins by mapping the focused ultrasonic beam in the vicinity of the focal spot and a parametric analysis providing the maximum peak-to-peak (PTP) pressure delivered by the probe under different acoustic conditions. The measured maximum PTP pressure at the targeted operating frequency of 1 MHz is 3 MPa, with a maximum of 3.6 MPa at 1.25 MHz. Based on an in vitro setup found in the literature, the temperature elevation at the focal point was measured, showing results in agreement with the targeted applications (max. ∆T = 7.5˚C). The article concludes with a reliability study considering the delivered pressure and the self-heating of the CMUT probe: the results show the good stability of the pressure amplitude over 1.8 × 10 9 cycles at a duty cycle of 40%, with a moderate internal heating of 3˚C.

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Section: Overview Of the Usgfus Cmut Probementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Evaluation of an Ultrasound-Guided Focused Ultrasound CMUT Probe for Targeted Therapy Applications

Gross¹,

Legros

Vince³

et al. 2018

OJAppS

Self Cite

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“…Research on MEMS (microelectromechanical systems) has seen an amazing growth during the last three decades, stimulated both by their interesting physical properties and their attractive application potential. One of those appealing MEMS devices is capacitive micromachined ultrasonic transducers (CMUTs) [1,2]. Advantages of CMUTs over conventional piezoelectric transducers include better impedance matching with fluids, broader bandwidth, stable device properties, the ease of fabrication, and the possibility of on-chip integration with electronics [3].…”

Section: Introductionmentioning

confidence: 99%

Pull-In Analysis of the Flat Circular CMUT Cell Featuring Sealed Cavity

Zhang¹,

Zhang

Du³

et al. 2015

Mathematical Problems in Engineering

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Capacitive micromachined ultrasonic transducers (CMUTs) are one of the appealing MEMS devices. Most studies treat CMUTs as rigid plates vibrating in open air, ignoring the mechanical boundary conditions for simplification and resulting in cumulative errors in coupled fields. This paper presents a new analytical model for the pull-in characteristics of the flat circular CMUT cell featuring sealed cavity. Utilizing the plate theory coupled with Boyle’s law, the paper establishes a strong relation between the pressures inside the sealed cavity and the pull-in characteristics for the first time. Not only did we point out that the existence of the pressure inside the sealed cavity cannot be omitted, but we also quantified the direct effect of the pressure ratios on the pull-in phenomenon. The pull-in voltages increase while the pull-in ratios decrease with the pressure ratios of the pressure inside the sealed cavity to the ambient pressure. The proposed calculation process delivers a good approximation of the pull-in voltages and displacements, which are consistent with COMSOL simulation results. Particularly, the percentage error of our calculation process is 6.986% for the worst case. Therefore, our proposed analytical model accurately and efficiently predicts the pull-in characteristics and this paper offers new perspectives and reference value in designing and modeling the CMUTs.

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“…Recently, a combined therapy and imaging ultrasound phased array utilizing CMUT technology was developed and experimentally tested, showing promise for ultrasound-guided drug delivery [292]. …”

Section: Experimental Image-guided Phased Array Systemsmentioning

confidence: 99%

Image-guided ultrasound phased arrays are a disruptive technology for non-invasive therapy

Hynynen¹,

Jones²

2016

Phys. Med. Biol.

106

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Focused ultrasound offers a non-invasive way of depositing acoustic energy deep into the body, which can be harnessed for a broad spectrum of therapeutic purposes, including tissue ablation, the targeting of therapeutic agents, and stem cell delivery. Phased array transducers enable electronic control over the beam geometry and direction, and can be tailored to provide optimal energy deposition patterns for a given therapeutic application. Their use in combination with modern medical imaging for therapy guidance allows precise targeting, online monitoring, and post-treatment evaluation of the ultrasound-mediated bioeffects. In the past there have been some technical obstacles hindering the construction of large aperture, high-power, densely-populated phased arrays and, as a result, they have not been fully exploited for therapy delivery to date. However, recent research has made the construction of such arrays feasible, and it is expected that their continued development will both greatly improve the safety and efficacy of existing ultrasound therapies as well as enable treatments that are not currently possible with existing technology. This review will summarize the basic principles, current statures, and future potential of image-guided ultrasound phased arrays for therapy.

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A cMUT probe for ultrasound-guided focused ultrasound targeted therapy

Cited by 26 publications

References 46 publications

Evaluation of an Ultrasound-Guided Focused Ultrasound CMUT Probe for Targeted Therapy Applications

Evaluation of an Ultrasound-Guided Focused Ultrasound CMUT Probe for Targeted Therapy Applications

Pull-In Analysis of the Flat Circular CMUT Cell Featuring Sealed Cavity

Image-guided ultrasound phased arrays are a disruptive technology for non-invasive therapy

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