A CMOS VEGF Sensor for Cancer Diagnosis Using a Peptide Aptamer-Based Functionalized Microneedle

Song, Seungwoo; Na, Jukwan; Jang, MoonHyung; Lee, Hyeyeon; Lee, Hye-Soo; Lim, Yong‐beom; Chae, Youngcheol

doi:10.1109/tbcas.2019.2954846

Cited by 30 publications

(14 citation statements)

References 15 publications

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“…Song et al 179 developed a complementary metal-oxide semiconductor (CMOS) biosensor for the specific, real-time detection of VEGF (vascular endothelial growth factor—a cancer biomarker). The analyte capture component comprised a solid AuSiO 2 microneedle array functionalised with peptide aptamers.…”

Section: Microneedle Diagnostic Platformsmentioning

confidence: 99%

Microneedle-based devices for point-of-care infectious disease diagnostics

Dixon

Skaria

Lau

et al. 2021

Acta Pharmaceutica Sinica B

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Recent infectious disease outbreaks, such as COVID-19 and Ebola, have highlighted the need for rapid and accurate diagnosis to initiate treatment and curb transmission. Successful diagnostic strategies critically depend on the efficiency of biological sampling and timely analysis. However, current diagnostic techniques are invasive/intrusive and present a severe bottleneck by requiring specialist equipment and trained personnel. Moreover, centralised test facilities are poorly accessible and the requirement to travel may increase disease transmission. Self-administrable, point-of-care (PoC) microneedle diagnostic devices could provide a viable solution to these problems. These miniature needle arrays can detect biomarkers in/from the skin in a minimally invasive manner to provide (near-) real-time diagnosis. Few microneedle devices have been developed specifically for infectious disease diagnosis, though similar technologies are well established in other fields and generally adaptable for infectious disease diagnosis. These include microneedles for biofluid extraction, microneedle sensors and analyte-capturing microneedles, or combinations thereof. Analyte sampling/detection from both blood and dermal interstitial fluid is possible. These technologies are in their early stages of development for infectious disease diagnostics, and there is a vast scope for further development. In this review, we discuss the utility and future outlook of these microneedle technologies in infectious disease diagnosis.

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Section: Microneedle Diagnostic Platformsmentioning

confidence: 99%

Microneedle-based devices for point-of-care infectious disease diagnostics

Dixon

Skaria

Lau

et al. 2021

Acta Pharmaceutica Sinica B

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“…These results are remarkable considering the massive efforts focused on the development of the label-(and indicator-) free approaches. Another label-free sensor for VEGF analysis in human blood exploited the complementary metal oxide semiconductor (CMOS) platform [23]. The VEGF binding by the peptide-aptamer-modified microneedles was followed by monitoring the capacitance changes between the microneedles by a two-step capacitance-to-digital converter (CDC).…”

Section: Vascular Endothelial Growth Factormentioning

confidence: 99%

“…The VEGF binding by the peptide-aptamer-modified microneedles was followed by monitoring the capacitance changes between the microneedles by a two-step capacitance-to-digital converter (CDC). The aptasensor detected VEGF at its 0.1 pM levels [23].…”

Section: Vascular Endothelial Growth Factormentioning

confidence: 99%

“…Hitherto, the peptide aptamers are rarely used in cancer diagnostic devices and thus are excluded from the scope of this review. Further the term "aptamer'' will be used here only in connection with the nucleic acids aptamers, except for one example of an aptasensor for vascular endothelial growth factor detection based on a peptide aptamer [23].…”

Section: Introductionmentioning

confidence: 99%

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Design Strategies for Electrochemical Aptasensors for Cancer Diagnostic Devices

Malecka

Mikuła

Ferapontova

2021

Sensors

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Improved outcomes for many types of cancer achieved during recent years is due, among other factors, to the earlier detection of tumours and the greater availability of screening tests. With this, non-invasive, fast and accurate diagnostic devices for cancer diagnosis strongly improve the quality of healthcare by delivering screening results in the most cost-effective and safe way. Biosensors for cancer diagnostics exploiting aptamers offer several important advantages over traditional antibodies-based assays, such as the in-vitro aptamer production, their inexpensive and easy chemical synthesis and modification, and excellent thermal stability. On the other hand, electrochemical biosensing approaches allow sensitive, accurate and inexpensive way of sensing, due to the rapid detection with lower costs, smaller equipment size and lower power requirements. This review presents an up-to-date assessment of the recent design strategies and analytical performance of the electrochemical aptamer-based biosensors for cancer diagnosis and their future perspectives in cancer diagnostics.

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“…Typically, hydrogel solution is poured into a metal or polydimethylsiloxane (PDMS)-based template mold, centrifuged to entirely fill the mold spacing (especially for viscous hydrogel solution filling small gaps like MN tips), and crosslinked (e.g., photoinitiator and UV irradiation) to allow hardening and subsequent removal of the gel structures from the mold [17,47]. Colorimetric, enzymatic, and/or electrochemical sensor moieties have been incorporated within hydrogel MNs in this fashion to facilitate the non-invasive assessment and monitoring of skin biomarkers without burdensome devices [48,49].…”

Section: Synthesis and Preparation Of Hydrogel Technologiesmentioning

confidence: 99%

Hydrogel-Based Technologies for the Diagnosis of Skin Pathology

et al. 2020

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Hydrogels, swellable hydrophilic polymer networks fabricated through chemical cross-linking or physical entanglement are increasingly utilized in various biomedical applications over the past few decades. Hydrogel-based microparticles, dressings and microneedle patches have been explored to achieve safe, sustained and on-demand therapeutic purposes toward numerous skin pathologies, through incorporation of stimuli-responsive moieties and therapeutic agents. More recently, these platforms are expanded to fulfill the diagnostic and monitoring role. Herein, the development of hydrogel technology to achieve diagnosis and monitoring of pathological skin conditions are highlighted, with proteins, nucleic acids, metabolites, and reactive species employed as target biomarkers, among others. The scope of this review includes the characteristics of hydrogel materials, its fabrication procedures, examples of diagnostic studies, as well as discussion pertaining clinical translation of hydrogel systems.

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A CMOS VEGF Sensor for Cancer Diagnosis Using a Peptide Aptamer-Based Functionalized Microneedle

Cited by 30 publications

References 15 publications

Microneedle-based devices for point-of-care infectious disease diagnostics

Microneedle-based devices for point-of-care infectious disease diagnostics

Design Strategies for Electrochemical Aptasensors for Cancer Diagnostic Devices

Hydrogel-Based Technologies for the Diagnosis of Skin Pathology

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