A CMOS neuroelectronic interface based on two-dimensional transistor arrays with monolithically-integrated circuitry

Chang, Che-Pei; Chang, Shih-Chieh; Lin, Jhih-Min; Lee, Y.T.; Yeh, Shih-Rung; Chen, H.

doi:10.1016/j.bios.2008.09.007

Cited by 4 publications

(2 citation statements)

References 41 publications

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“…As the ISFET is employed to detect transient potential changes (e.g., neural activity), the potential changes are normally transduced into drain currents for further amplification and filtering [34,35]. A large transconductance ( g m ) is thus important for ensuring the sensitivity of the ISFET.…”

Section: Resultsmentioning

confidence: 99%

A CMOS-Compatible, Low-Noise ISFET Based on High Efficiency Ion-Modulated Lateral-Bipolar Conduction

Chang

Chen

2009

Sensors

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Ion-sensitive, field-effect transistors (ISFET) have been useful biosensors in many applications. However, the signal-to-noise ratio of the ISFET is limited by its intrinsic, low-frequency noise. This paper presents an ISFET capable of utilizing lateral-bipolar conduction to reduce low-frequency noise. With a particular layout design, the conduction efficiency is further enhanced. Moreover, the ISFET is compatible with the standard CMOS technology. All materials above the gate-oxide are removed by simple, die-level post-CMOS process, allowing ions to modulate the lateral-bipolar current directly. By varying the gate-to-bulk voltage, the operation mode of the ISFET is controlled effectively, so is the noise performance measured and compared. Finally, the biasing conditions preferable for different low-noise applications are identified. Under the identified biasing condition, the signal-to-noise ratio of the ISFET as a pH sensor is proved to be improved by more than five times.

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Section: Resultsmentioning

confidence: 99%

A CMOS-Compatible, Low-Noise ISFET Based on High Efficiency Ion-Modulated Lateral-Bipolar Conduction

Chang

Chen

2009

Sensors

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“…Examples 4 Author to whom any correspondence should be addressed. include those based on the electrochemical [2,3], impedimetric [4][5][6], ion-sensitive [7,8], magnetic [9,10], optical [11,12] and micromechanical [13,14] approaches. These IC-based biosensors, like many nonintegrated biosensor chips, do not provide on-chip manipulation to move biomolecules to the sensing sites; similarly, many microfluidic biochips capable of manipulating biomolecules do not provide onchip biosensing capabilities.…”

Section: Introductionmentioning

confidence: 99%

An integrated micro-manipulation and biosensing platform built in glass-based LTPS TFT technology

Chen

2012

J. Micromech. Microeng.

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The glass-based low-temperature polycrystalline-silicon (LTPS) thin-film transistor (TFT) process, widely known for making liquid crystal displays, is utilized in this work to realize a fully integrated, microbead-based micro-manipulation and biosensing platform. The operation utilizes arrays of microelectrodes made of transparent iridium tin oxide (ITO) to move the immobilized polystyrene microbeads to the sensor surface by dielectrophoresis (DEP). Detection of remaining microbeads after a specific antigen/antibody reaction is accomplished by photo-detectors under the transparent electrodes. It was found that microbeads can be driven successfully by the 30 × 30 μm 2 microelectrodes separated by 10 μm with no more than 6 V p-p , which is compatible with the operating range of thin-film transistors. Microbeads immobilized with antimouse immunoglobulin (IgG) and prostate-specific antigen (PSA) antibody were successfully detected after specific binding, illustrating the potential of LTPS TFT microarrays for more versatile biosensing applications.

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Drift compensation using bulk feedback in a neural recording system based on open-gate FET

Vijayan

Sreenivasan

Nair

et al. 2015

2015 International Conference on Smart Sensors and Application (ICSSA)

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A CMOS neuroelectronic interface based on two-dimensional transistor arrays with monolithically-integrated circuitry

Cited by 4 publications

References 41 publications

A CMOS-Compatible, Low-Noise ISFET Based on High Efficiency Ion-Modulated Lateral-Bipolar Conduction

A CMOS-Compatible, Low-Noise ISFET Based on High Efficiency Ion-Modulated Lateral-Bipolar Conduction

An integrated micro-manipulation and biosensing platform built in glass-based LTPS TFT technology

Drift compensation using bulk feedback in a neural recording system based on open-gate FET

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