2016
DOI: 10.1136/thoraxjnl-2016-208535
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A clustering approach to identify severe bronchiolitis profiles in children

Abstract: Objective Although bronchiolitis is generally considered a single disease, recent studies suggest heterogeneity. We aimed to identify severe bronchiolitis profiles using a clustering approach. Methods We analyzed data from two prospective, multi-center cohorts of children younger than 2 years hospitalized with bronchiolitis, one in the U.S. (2007–2010 winter seasons, n=2,207) and one in Finland (2008–2010 winter seasons, n=408). Severe bronchiolitis profiles were determined by latent class analysis, classify… Show more

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Cited by 82 publications
(141 citation statements)
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“…That the association for early wheeze is stronger implies that this is more complicated than the revealing of an innate state. It may be that different clinical phenotypes of bronchiolitis13 would be helpful in this prognostication, but we were not able to assess this using this dataset.…”
Section: Discussionmentioning
confidence: 98%
“…That the association for early wheeze is stronger implies that this is more complicated than the revealing of an innate state. It may be that different clinical phenotypes of bronchiolitis13 would be helpful in this prognostication, but we were not able to assess this using this dataset.…”
Section: Discussionmentioning
confidence: 98%
“…3% HS nebulizations cause minor and severe adverse events as seen in our study. The association between adverse events and the potential role of nebulization, medication and nebulizer utilized, and bronchiolitis phenotype [31] needs further exploration.…”
Section: Resultsmentioning
confidence: 99%
“…Todo lo anterior pone en evidencia que la bronquiolitis es una enfermedad heterogénea en su cuadro clínico y que depende de diversos factores, como el virus patógeno y su interacción con el microbioma de la vía aérea, la respuesta inmune, la genética del huésped y factores ambientales. 8,9 Por lo tanto, es muy probable que un mismo esquema terapéutico no sea lo más adecuado para tratar a todos los pacientes.…”
Section: Bronchodilators In Bronchiolitis: Yes or No?unclassified