A Closed-Loop Approach to Fight Coronavirus: Early Detection and Subsequent Treatment

Abstract

The recent COVID-19 pandemic has caused tremendous damage to the social economy and people’s health. Some major issues fighting COVID-19 include early and accurate diagnosis and the shortage of ventilator machines for critical patients. In this manuscript, we describe a novel solution to deal with COVID-19: portable biosensing and wearable photoacoustic imaging for early and accurate diagnosis of infection and magnetic neuromodulation or minimally invasive electrical stimulation to replace traditional ventilation. The solution is a closed-loop system in that the three modules are integrated together and form a loop to cover all-phase strategies for fighting COVID-19. The proposed technique can guarantee ubiquitous and onsite detection, and an electrical hypoglossal stimulator can be more effective in helping severe patients and reducing complications caused by ventilators.

Machine Learning Techniques for Effective Pathogen Detection Based on Resonant Biosensors

“…Biosensor technologies have high sensitivity, good specificity, fast turnaround, ease of operation, low cost, and onsite deployment capability [ 12 , 13 ]. We have previously proposed a photonic biosensor with high sensitivity and specificity for the fast, on-site detection of SARS-CoV-2 [ 14 , 15 ]. The biosensor is based on a nanoporous silicon material fabricated via a CMOS-compatible silicon process and nanophotonic working principles of localized surface plasmon resonance (LSPR) [ 16 ] and Tamm plasmon polariton (TPP) [ 17 , 18 ].…”

Tamm Plasmon Polariton Biosensors Based on Porous Silicon: Design, Validation and Analysis

“…Researchers have proposed optical biosensors based on optic fiber [6], optical waveguide [7], ring resonator [8], optical interferometer [9], photonic crystal [10], surface plasmon resonance (SPR) [11], and localized surface plasmon resonance (LSPR) [12]. Optical biosensors have been demonstrated for the detection of bacteria [13], virus [14], DNA [15], proteins [16], and small molecules [17].…”