A clinicopathological study of gastric cancer with special reference to age of the patients: An analysis of 1,630 cases

Mitsudomi, Tetsuya; Matsusaka, T; Wakasugi, Kenzo; Takenaka, Motoyasu; Kume, Kazuhiro; Fujinaga, Y; Teraoka, Hiroaki; Iwashita, Akinori

doi:10.1007/bf01658407

Cited by 55 publications

(58 citation statements)

References 17 publications

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“…Although in some studies, it proved that age is a significant factor in lifetime (Matley et al, 1988;Mitsudomi et al, 1989;Arveux et al, 1992;Maehara et al, 1995;Haugstvedt et al, 1993;Bucchi et al, 2004;Enzinger and Mayer, 2004;Saidi et al, 2004) there was no significant relationship between age and the lifetime in this study but, in some other studies there was shown that there is not a significant relationship between age and the lifetime (Khedmat et al, 2007;Biglarian et al, 2009;Roshanaei et al, 2010).…”

Section: Discussioncontrasting

confidence: 53%

Estimation of Hazard Function and its Associated Factors in Gastric Cancer Patients using Wavelet and Kernel Smoothing Methods

Ahmadi

Roudbari

Gohari³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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Background and Objectives: Increase of mortality rates of gastric cancer in Iran and the world in recent years reveal necessity of studies on this disease. Here, hazard function for gastric cancer patients was estimated using Wavelet and Kernel methods and some related factors were assessed. Materials and Methods: Ninetyfive gastric cancer patients in Fayazbakhsh Hospital between 1996 and 2003 were studied. The effects of age of patients, gender, stage of disease and treatment method on patient's lifetime were assessed. For data analyses, survival analyses using Wavelet method and Log-rank test in R software were used. Results: Nearly 25.3% of patients were female. Fourteen percent had surgery treatment and the rest had treatment without surgery. Three fourths died and the rest were censored. Almost 9.5% of patients were in early stages of the disease, 53.7% in locally advance stage and 36.8% in metastatic stage. Hazard function estimation with the wavelet method showed significant difference for stages of disease (P<0.001) and did not reveal any significant difference for age, gender and treatment method. Conclusion: Only stage of disease had effects on hazard and most patients were diagnosed in late stages of disease, which is possibly one of the most reasons for high hazard rate and low survival. Therefore, it seems to be necessary a public education about symptoms of disease by media and regular tests and screening for early diagnosis.

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Section: Discussioncontrasting

confidence: 53%

Estimation of Hazard Function and its Associated Factors in Gastric Cancer Patients using Wavelet and Kernel Smoothing Methods

Ahmadi

Roudbari

Gohari³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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“…Previous data have shown that GC occurs predominantly in older age groups, with a peak age at the sixth decade [9]. However, there has been some concern about a trend toward steadily increasing GC in young patients over the past few decades and studies were conducted to define the demographic, clinicopathologic and prognostic factors of GC in young patients [10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Clinical characteristics and outcomes for gastric cancer patients aged 18–30 years

et al. 2014

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Background There is little known about the clinicopathological features and the predictors of survival in extremely young adult patients aged 18-30 years. The aim of this study was to identify clinicopathological features and clinical outcomes for the overall population and for a resectable subgroup of gastric cancer patients aged 18-30 years.Methods From January 2004 to December 2010, 207 patients aged between 18 and 30 years old were diagnosed with gastric cancer and treated at the Asan Medical Center. Clinical findings, histopathological parameters and outcomes were reviewed retrospectively. Patients were further divided into 2 groups according to tumor resectability and then clinicopathological factors that affect tumor resectability and clinical outcomes were analyzed. Results Clinicopathological characteristics of study population showed a predominance of females, undifferentiated tumors, diffuse-type cancers, and advanced gastric cancer. The overall resectability rate was 70.0 % and the median follow-up period was significantly longer in the resectable tumor group (P \ 0.001). Significant prognostic predictors for overall survival in overall patients were higher CEA levels (P = 0.016), larger tumor size (P \ 0.001), unresectability (P = 0.006), and presence of lymphovascular invasion (P = 0.012) in a multivariate analysis. Significant prognostic factors for overall survival in patients with resectable disease included larger tumor size ([4 cm), lymphovascular invasion and higher CEA level in the multivariate analysis. Conclusions Gastric adenocarcinomas in young adult patients aged 18-30 years have unique clinicopathological features. Early detection in a resectable state and subsequent complete resection could increase survival period in young patients with gastric cancer.

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“…In the case of gastric cancer, some authors have reported a close relationship between the prognosis and age of the patients and others have not found a relationship (Grabiec & Owen, 1985;Mitsudomi et al, 1989). Lundegardh et al (1986) reported that, for 34,549 patients surgically or non-surgically treated, the mortality rate for men over age 75 years was slightly higher, but there was no clear relationship, between prognosis based on clinical criteria, and age at diagnosis.…”

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confidence: 99%

Death due to recurrence following curative resection of early gastric cancer depends on age of the patient

Moriguchi

Odaka²,

Hayashi³

et al. 1991

Br J Cancer

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The prognosis of patients with malignancy depends upon biologic aspects of the tumour, tumour-host relationship, and the therapy prescribed. In the case of gastric cancer, some authors have reported a close relationship between the prognosis and age of the patients and others have not found a relationship (Grabiec & Owen, 1985;Mitsudomi et al., 1989). Lundegardh et al. (1986) reported that, for 34,549 patients surgically or non-surgically treated, the mortality rate for men over age 75 years was slightly higher, but there was no clear relationship, between prognosis based on clinical criteria, and age at diagnosis. Bozzetti et al. (1986) found that for patients who underwent gastrectomy survival time decreased with increasing age of the patient at the time of operation. In contrast, Coluccia et al. (1987) reported that, in patients over age 65 years, surgical resection of the gastric cancer favoured survival. In an 'early' gastric cancer, several factors are related to the prognosis (Inokuchi et al., 1983;Kodama et al., 1983;Fukutomi & Sakita, 1984;Kitaoka et al., 1984;Koga et al., 1984;Habu et al., 1986;Itoh et al., 1989). The relationship between age and prognosis due to recurrence after resection of early gastric cancer was examined herein. Adjustment for other clinicopathological prognostic factors was made using univariate and multivariate analyses. Materials and methods PatientsFor this retrospective study, we used data from 385 consecutive patients with no other simultaneous malignancy. All the patients had been treated by 'curative' gastrectomy for primary early gastric cancer, between January 1965 and December 1985 in the Department of Surgery II, Kyushu University Hospital. Early gastric cancer is defined as a lesion in which cancerous invasion is confined to the mucosa, or mucosa and submucosa, regardless of the regional lymph node metastases (Japanese Research Society for Gastric Cancer, 1981 (Dixon, 1988). The BMDP P4F and P3S programs were used in cases of the chi-square test and the Wilcoxon signed-rank test in compare groups of patients with respect to each characteristic. The BMDP PIL program was used to analyse the survival rates, using the Kaplan-Meier method, and to test for disparity of the survival curves, using the method of Mantel-Cox and the generalised Wilcoxon tests. The BMDP P2L program was used to determine which variables were independent prognostic factors for survival time by the Cox proportional hazard model in a stepwise manner (Cox, 1972). In a Cox regression analysis, age and size of tumour were included as continuous variables. Results MortalityAt the time of this analysis of data on 382 patients who underwent curative gastrectomy for early gastric cancer, the median follow-up time for 274 survivors (71.7%) was 10.2 years and 108 had died during this follow-up period (mortality, 28.3%). Of the 108 deaths, 25 were related to a recurrence of the gastric cancer (mortality, 6.5%), 18 were due to another malignancy (mortality, 4.7%) and 65 were due to another disease or to an acci...

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A clinicopathological study of gastric cancer with special reference to age of the patients: An analysis of 1,630 cases

Cited by 55 publications

References 17 publications

Estimation of Hazard Function and its Associated Factors in Gastric Cancer Patients using Wavelet and Kernel Smoothing Methods

Estimation of Hazard Function and its Associated Factors in Gastric Cancer Patients using Wavelet and Kernel Smoothing Methods

Clinical characteristics and outcomes for gastric cancer patients aged 18–30 years

Death due to recurrence following curative resection of early gastric cancer depends on age of the patient

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