A clinicopathological aspect of primary small-cell carcinoma of the uterine cervix: a single-centre study of 25 cases

Li, Jun Dong; Zhuang, Yuan; Li, Yan Fang; Yang, Feng; Hou, Jin Hui; Chen, Liang; Zhu, An Na; Wu, Qiu Liang; Yun, Jing Ping

doi:10.1136/jclinpath-2011-200274

Cited by 29 publications

(16 citation statements)

References 29 publications

(30 reference statements)

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“…However, past studies have shown disagreement in the 5-year overall survival (OS) rate of SCNEC. The lowest rate was reported by Li et al as 4% [3] and the highest was reported by Chen et al as 51% [4].…”

Section: Introductionmentioning

confidence: 79%

Clinicopathological Aspects of Small Cell Neuroendocrine Carcinoma of the Uterine Cervix: a Multicenter Retrospective Study and Meta-Analysis

et al. 2018

Cell Physiol Biochem

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Background/Aims: To evaluate the clinicopathologic aspects of small cell neuroendocrine carcinoma of the uterine cervix (SCNEC). Methods: A retrospective review of 40 patients with SCNEC in 3 hospitals from 2009 to 2015 was conducted to assess the survival rates and examine the associations between clinicopathological variables and overall survival (OS). A meta-analysis of 22 studies containing 1901 patients was also conducted to further confirm the results. Results: In the clinical group of 40 patients, the 5-year OS rate was 20%. Advanced International Federation of Gynecology and Obstetrics (FIGO) stage and radiation therapy (RT) were associated with poor survival. However, radical surgery was associated with prolonged survival. In the meta-analysis of 1901 patients, the 2-year disease-free survival (DFS) rate, 5-year DFS rate, 2-year OS rate, 3-year OS rate and 5-year OS rate of SCNEC were 48%, 35%, 62%, 35%, and 35% respectively. Advanced FIGO stage, larger tumor size, lymph node metastasis (LNM) (+), lymphovascular space involvement (LVSI) (+), parametrial involvement (PI) (+), depth of stromal invasion (DSI) > 2/3, and RT were associated with poor survival. However, a chemotherapy regimen similar to that for small cell lung cancer was associated with prolonged survival. Conclusion: Advanced FIGO stage, larger tumor size, LNM (+), LVSI (+), DSI > 2/3, PI (+), and RT were independent predictors of poor prognosis of SCNEC. Radical surgery combined with a chemotherapy regimen similar to that of small cell lung cancer may be a potential therapeutic approach for SCNEC.

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Section: Introductionmentioning

confidence: 79%

Clinicopathological Aspects of Small Cell Neuroendocrine Carcinoma of the Uterine Cervix: a Multicenter Retrospective Study and Meta-Analysis

et al. 2018

Cell Physiol Biochem

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“…Attention to the histologic features of neuroendocrine differentiation and the immunohistochemical staining of neuroendocrine markers is necessary to reach a correct diagnosis. CD56 is known to be a less specific neuroendocrine marker compared to chromogranin and synaptophysin [ 11 , 20 , 55 ]. The common coexistence of NEC and epithelial tumors along with the monoclonality of the two components implies a common cellular origin of the neuroendocrine and epithelial components [ 17 , 72 ].…”

Section: Discussionmentioning

confidence: 99%

“…Chromogranin, synaptophysin, and CD56 are commonly used neuroendocrine markers. However, CD56 is considered a less specific marker of neuroendocrine differentiation compared to chromogranin and synaptophysin [ 11 , 20 ]. This staining should be carefully interpreted, as CD56 can be present in non-NECs, such as squamous cell carcinomas and adenocarcinomas [ 20 ].…”

Section: Neuroendocrine Tumors Of the Uterine Cervixmentioning

confidence: 99%

“…Attention to the histologic features of neuroendocrine differentiation and the use of immunohistochemical stains are necessary to resolve this potential underrecognition [ 64 ]. CD56 is known to be a less specific neuroendocrine marker compared to chromogranin and synaptophysin [ 11 , 20 , 55 ]. However, chromogranin and synaptophysin can be detected in ovarian Sertoli cell tumors, Sertoli-Leydig cell tumors, and endometrioid tumors, which could be a potential pitfall resulting in the misdiagnosis of NETs [ 55 , 73 ].…”

Section: Neuroendocrine Tumors Of the Ovarymentioning

confidence: 99%

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Neuroendocrine Tumors of the Female Reproductive Tract: A Literature Review

Chun¹

2015

J Pathol Transl Med

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Neuroendocrine tumors of the female reproductive tract are a heterogeneous group of neoplasms that display various histologic findings and biologic behaviors. In this review, the classification and clinicopathologic characteristics of neuroendocrine tumors of the female reproductive tract are described. Differential diagnoses are discussed, especially for non-neuroendocrine tumors showing high-grade nuclei with neuroendocrine differentiation. This review also discusses recent advances in our pathogenetic understanding of these disorders.

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“…The diagnosis of SCCC was aided by immunohistochemical staining for common neuroendocrine markers, including Syn, CgA, neuron-specific enolase (NSE) and CD56. Typically, SCCC samples exhibit 100, 96.0, 68.0, 76.0, 40.0, 84.0, 68.0 and 8.0% positivity for NSE, Syn, CD56, CgA, thyroid transcription factor-1, epithelial membrane antigen, cytokeratin and S100 immunohistochemical biomarkers, respectively ( 5 ).…”

Section: Discussionmentioning

confidence: 99%

Small cell carcinoma of the uterine cervix in pregnancy: A case report and review of the literature

et al. 2014

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Abstract. The occurrence of cervical cancer during pregnancy is extremely rare, particularly small cell carcinoma. Small cell cervical carcinoma (SCCC) is a neuroendocrine tumor with a poor prognosis. This study presents the case of an 18-year-old female with stage IB2 SCCC complicated by pregnancy, who was treated with chemotherapy and radiotherapy. The patient was diagnosed shortly after giving birth, and is the youngest female case to be reported in the world. The patient was treated with cisplatin and etoposide chemotherapy and radiotherapy. Complete remission was achieved following neoadjuvant chemotherapy and radiotherapy, and the patient remains in clinical remission eight months following treatment. Cytological screening, colposcopy and if necessary, biopsy, and selective conization at 14-20 weeks should be considered in the patient evaluation.

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A clinicopathological aspect of primary small-cell carcinoma of the uterine cervix: a single-centre study of 25 cases

Cited by 29 publications

References 29 publications

Clinicopathological Aspects of Small Cell Neuroendocrine Carcinoma of the Uterine Cervix: a Multicenter Retrospective Study and Meta-Analysis

Clinicopathological Aspects of Small Cell Neuroendocrine Carcinoma of the Uterine Cervix: a Multicenter Retrospective Study and Meta-Analysis

Neuroendocrine Tumors of the Female Reproductive Tract: A Literature Review

Small cell carcinoma of the uterine cervix in pregnancy: A case report and review of the literature

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