Neuroendocrine Tumors of the Female Reproductive Tract: A Literature Review

Chun, Yi Kyeong

doi:10.4132/jptm.2015.09.20

Cited by 42 publications

(70 citation statements)

References 75 publications

(103 reference statements)

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“…[9] Usually, endometrial NECs are combined with other epithelial neoplasms; in detail, 50-80% of cases are admixed with FIGO grade 1 or 2 endometrioid adenocarcinoma. [6,7] To explain this intriguing association it has been hypothesized that some endometrial NECs may arise from the neuroendocrine component of endometrioid carcinomas. [10] Although the possibility that an abdominal NEC may secondarily develop due to chemotherapy for an original endometrial carcinoma should be mentioned, nevertheless in the present case this option should be excluded since the first diagnosis and consequently the therapeutical approach were based on colonic poorly differentiated carcinoma.…”

Section: Discussionmentioning

confidence: 99%

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Uterine large cell neuroendocrine carcinoma with unusual colonic metastasis

Ieni¹,

Angelico²,

Sarro³

et al. 2017

JCMT

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A 78-year-old female patient arrived at our practice complaining of progressive abdominal increase and presenting a clinical picture of intestinal obstruction. At physical examination, the abdomen appeared distended, moderately painful with the presence of a mass of hard consistency. Abdominal computed tomography scan showed a large hypodense pelvic mass that indicated a compression and lateral deviation of the uterus and bladder. Microscopically, the mass showed a uniform solid pattern, composed of medium and large-sized cells with hyperchromatic and pleomorphic nuclei demonstrating high mitotic activity and diffuse immunoreactivity for estrogen receptors and synaptophysin. A diagnosis of uterine poorly differentiated large cell neuroendocrine carcinoma, arising in the endometrium with an unusual colonic metastatic localization, was made. Key words:Neuroendocrine carcinoma, metastasis, uterus, differential diagnosis, immunohistochemistry ABSTRACTArticle history:

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Section: Discussionmentioning

confidence: 99%

“…[6,7] According to World Health Organization classification, NETs are classified in two principal groups: poorly differentiated neuroendocrine carcinomas (NECs) and welldifferentiated NETs. [8] NECs include small and large cell neuroendocrine carcinoma, while NETs include typical and atypical carcinoids.…”

Section: Discussionmentioning

confidence: 99%

Uterine large cell neuroendocrine carcinoma with unusual colonic metastasis

Ieni¹,

Angelico²,

Sarro³

et al. 2017

JCMT

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“…H&E, X400; Benign endometrial gland yanısıra stromada infiltrasyon oluşturan küçük hiperkromatik nukleuslu tümör hücreleri görülüyor TARTIŞMA Kadın genital sisteminin primer NET'leri çeşitli biyolojik davranışlar ve farklı histopatolojik görünümlere sahip, nadiren ortaya çıkan heterojen bir grup tümö-ral lezyonlardır. Serviks ve over yerleşimi daha sık olup literatürde primer endometrial kökenli olanlar az sayıda bildirilmektedir [2,4]. Bu tümörlerin endometriumda nereden kaynaklandığı konusunda hala tartışmalar mevcuttur.…”

Section: Olguunclassified

“…Tüm jinekolojik kanserlerin yaklaşık %2'sini oluştururlar. En sık serviks ve overlerde gözlenirler [2]. [4].…”

Section: Introductionunclassified

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Benign Endometrial Polyp and Primary Endometrial Small Cell Neuroendocrine Carcinoma Confined to the Polyp: A Rare Association

Oltulu

Uğurluoğlu²,

Uğur³

et al. 2016

Journal of Clinical and Experimental Investigations

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Neuroendocrine tumors (NETs) are a heterogeneous group of tumoral lesions originating from diffuse endocrine system cells. They occur mostly in the gastrointestinal system and the lung. Primary NETs of the female reproductive tract are rare. In a widely used classification, primary small cell neuroendocrine carcinomas (SCNECs) and large cell neuroendocrine carcinomas (LCNECs) of the endometrium were included in a subgroup of poorly differentiated neuroendocrine carcinomas. SCNECs of the endometrium are very rare and they are often combined with other epithelial neoplasms. Their myometrial and extrauterine invasions are common during the initial diagnosis due to their aggressive behaviors. In this article, we present a rare case of primary endometrial SC-NEC detected within the benign endometrial polyp and without invasion of myometrium and extrauterine tissues in a 70-year-old female patient presenting with postmenopausal bleeding. Histopathologically, the tumor cells showed positive staining with Synaptophysin, the Ki-67 labeling index was 80-90%, the mitotic index was 15/10 per HPF and there was no necrosis and lymphovascular invasion. J Clin Exp Invest 2016; 7 (1): 106-109

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