A clinicopathologic study of mucinous adenocarcinoma of the stomach

Kawamura, Hideki; Kondo, Yukifumi; Osawa, Shohei; Nisida, Yasunori; Okada, Ken-ichi; Isizu, Hiroyuki; Uebayasi, Takasi; Takahasi, M.; Hata, Tunetake

doi:10.1007/pl00011728

Cited by 53 publications

(63 citation statements)

References 9 publications

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“…However, no such significant differences in survival rates were observed between the two groups when the patients were stratified according to their disease stage. Our results were in agreement with those of Yasuda et al (11) and Kawamura et al (5). Furthermore, the multivariate analysis demonstrated that mucinous histological type was not a prognostic indicator in patients with gastric cancer.…”

Section: Univariate Analysissupporting

confidence: 93%

“…Additionally, peritoneal metastasis was more frequently observed in MGC, whereas hepatic metastasis was more common in NMGC cases. The rare incidence of hepatic metastasis in MGC was in accordance with the results reported by Kawamura et al (5). The presence of a mucinous component is generally associated with poor prognosis in colorectal cancer patients (15).…”

Section: Univariate Analysissupporting

confidence: 90%

“…Undifferentiated gastric carcinomas are generally associated with a worse prognosis (3). Mucinous gastric carcinoma (MGC) is a rare histological subtype of undifferentiated gastric carcinoma, accounting for 2.6-6.6% of all gastric cancer cases (4)(5)(6)(7)(8). The available literature on MGC is currently limited, mostly due to its rarity.…”

Section: Introductionmentioning

confidence: 99%

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Characteristics and prognosis of mucinous gastric carcinoma

Isobe

Hashimoto

Kizaki

et al. 2014

Molecular and Clinical Oncology

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Abstract. Mucinous gastric carcinoma (MGC) is a rare histological subtype of undifferentiated gastric carcinoma, accounting for ~2.6-6.6% of all gastric cancer cases. The clinicopathological characteristics and prognosis of MGC are controversial. The present study aimed to determine the clinicopathological characteristics and prognosis of patients with MGC. We retrospectively compared the characteristics and postoperative survival of 70 patients with MGC and 2,492 non-MGC (NMGC) cases who underwent surgical resection between 1990 and 2010. MGC was characterised by larger tumor size, macroscopic Borrmann type 2 and 3, T4 invasion of the gastric wall, positive N2 and N3 lymph node metastasis, positive lymphatic vessel invasion, positive venous invasion, peritoneal metastasis and advanced tumor stage III and IV. The prognosis of MGC patients was worse compared to that of NMGC patients, as the former group consisted of more advanced-stage cases. When patients with similar disease stages were compared, the incidence of peritoneal metastasis was significantly higher among MGC patients. However, hepatic metastasis was found significantly more often in NMGC patients. Otherwise, the prognosis of MGC and NMGC patients with similar disease stages was not significantly different. Therefore, our findings indicated that, although MGC is more rare and mostly detected at an advanced stage, the diagnosis of the mucinous histological subtype was not an independent prognostic factor.

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Section: Univariate Analysissupporting

confidence: 93%

Section: Univariate Analysissupporting

confidence: 90%

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Characteristics and prognosis of mucinous gastric carcinoma

Isobe

Hashimoto

Kizaki

et al. 2014

Molecular and Clinical Oncology

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“…The incidence of mucinous colorectal adenocarcinoma is 5.7% to 11.7% of colorectal cancers. 1 According to the Japanese Research Society for Gastric Cancer, mucinous carcinoma is defined as a morphologic subtype of adenocarcinoma in which more than 50% of the tumor is composed of mucin. 2 Another variant, signet ring cell carcinoma, also produces abundant mucin that is intracytoplasmic rather than extracytoplasmic.…”

Section: Discussionmentioning

confidence: 99%

“…1,2 The reported incidence of MGC among all gastric carcinomas is 3% to 5%. 3,4 These tumors are mostly in an advanced stage and rarely in an early stage.…”

Section: Introductionmentioning

confidence: 99%

Submucosal Tumor-like Early-stage Mucinous Gastric Carcinoma: A Case Study

Yoo

Park

et al. 2013

Korean J Gastroenterol

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Mucinous gastric carcinoma (MGC) is an unusual histologic subtype, and early detection of MGC is very rare. Early-stage MGC appears as an elevated lesion resembling a submucosal tumor (SMT) due to abundant mucin pools in the submucosa or mucosa. We report a rare case of SMT-like early-stage MGC. Tumor type was predicted preoperatively based on characteristic endoscopic findings, in which an SMT-like mass was observed at the gastric fundus. The tumor was covered by nearly normal mucosa, but with an opening allowing for the passage of copious mucus discharge. A total gastrectomy with Roux-en-Y esophagojejunostomy was subsequently performed. Histopathology of the tumor revealed early-stage (lamina propria) mucinous adenocarcinoma. (Korean J Gastroenterol 2013;62:122-125)

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Mucinous gastric carcinomas

Choi

Kim

Lee

et al. 2009

Cancer

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BACKGROUND: Mucinous gastric carcinoma (MGC) is characterized by substantial mucous lakes within tumors and comprises 3% of gastric carcinomas at the authors' institute. METHODS: The authors analyzed the clinicopathologic characteristics, mucin gene expression profiles, microsatellite instability (MSI), and status of the human epidermal growth factor receptor 2 (HER‐2) and epidermal growth factor receptor (EGFR) genes in 133 MGCs and compared them with the same variables in nonmucinous gastric carcinomas (NMGCs). In addition, the prognostic implications of clinicopathologic parameters were evaluated. RESULTS: Patients who had MGC had deeper invasion (P = .003), more frequent lymph node metastasis (P < .001), more advanced pathologic stage (P < .001), more frequent lymphatic invasion (P < .001), and lower disease‐specific survival rates (P < .0001) than patients who had NMGC. However, a mucinous histology per se was not identified as an independent prognostic factor. Negative mucin 1, cell surface associated (MUC1) status (P < .001); positive mucin 2, oligomeric mucus/gel‐forming (MUC2) status (P < .001); negative mucin 5AC, oligomeric mucus/gel‐forming (MUC5AC) status (P = .036); and negative mucin 6, oligomeric mucus/gel‐forming (MUC6) status (P < .001) were more frequent in MGCs. The frequency of MSI in MGC was not significantly different from that in NMGC. MGCs had a significantly lower incidence of HER‐2 protein overexpression (P = .046), HER‐2 gene amplification (P = .009), and EGFR protein overexpression (P = .017) than NMGCs; and multivariate analysis identified EGFR overexpression as a factor associated with a poor prognosis (P = .047). Patients with MGC who had a predominance of signet ring cells in mucin pools had poorer disease‐specific survival than patients who had MGC with predominant tubular differentiation (P = .017). CONCLUSIONS: The clinicopathologic and molecular characteristics of MGCs differed from those of NMGCs. Furthermore, the results indicated that EGFR overexpression and histologic subtyping by predominant tumor cell type in mucin pools may be helpful for predicting clinical outcome in patients with MGC. Cancer 2009. © 2009 American Cancer Society.

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A clinicopathologic study of mucinous adenocarcinoma of the stomach

Cited by 53 publications

References 9 publications

Characteristics and prognosis of mucinous gastric carcinoma

Characteristics and prognosis of mucinous gastric carcinoma

Submucosal Tumor-like Early-stage Mucinous Gastric Carcinoma: A Case Study

Mucinous gastric carcinomas

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