Mucinous gastric carcinomas

Choi, Jong Hoon; Kim, Min A; Lee, Hee Eun; Lee, Hye Seung; Kim, Woo Ho

doi:10.1002/cncr.24422

Cited by 48 publications

(25 citation statements)

References 20 publications

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“…Peritoneal metastases were twice as common in signet ring adenocarcinoma compared with generic type adenocarcinoma, whereas metastases apparently arisen by hematologic spread were less frequent. Mucus produced by adenocarcinomas may infiltrate the surrounding stroma and help the tumor invading the stroma more rapidly, thus facilitating spread to the serosa and within the peritoneal fluid [18]. There might also be a genetic link between peritoneal growth and mucin production.…”

Section: Discussionmentioning

confidence: 99%

Metastatic spread in patients with gastric cancer

et al. 2016

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BackgroundThe epidemiology of metastatic gastric cancer is unexplored because cancer registries seldom cover metastatic involvement apart from “present or not”. We used a novel approach by utilizing Swedish registers to assess metastatic spread in gastric cancer. To our knowledge, this is the first nationwide description of metastases in gastric cancer.ResultsThe most common sites of metastasis were liver (in 48% of metastatic cancer patients), peritoneum (32%), lung (15%), and bone (12%). Metastases to the lung, nervous system, and bone were more frequent in cardia cancer and men, whereas non-cardia cancer more frequently metastasized within the peritoneum. Signet ring adenocarcinomas more frequently metastasized within the peritoneum, bone and ovaries, and less frequently to the lungs and liver compared with generic adenocarcinoma. The liver and the peritoneum were commonly single metastases while lung metastases occurred frequently together with liver metastases. The median survival in metastatic gastric cancer was 3 months, worst among those with bone and liver metastases (2 months).MethodsA total of 7,559 patients with gastric cancer were identified. Metastatic patterns and survival depending on sex, age, stage, anatomical location (cardia and non-cardia), and histological type were assessed.ConclusionsThe patterns of metastasis differ notably depending on histological type. Cardia cancer exhibits a completely different metastatic behavior than non-cardia cancer. Awareness of the differing patterns may guide in tailored diagnosis of metastases. Survivors from cardia cancer would benefit from increased surveillance of extraperitoneal metastases. Bone metastases should be considered in patients with signet ring adenocarcinoma if symptoms emerge.

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Section: Discussionmentioning

confidence: 99%

Metastatic spread in patients with gastric cancer

et al. 2016

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“…In a recent published study, 133 mucinous gastric carcinomas (MGC) were compared with nonmucinous gastric carcinomas (NMGC) [182]. Key findings included that MGC tumor had deeper invasion, frequently metastasized to lymph nodes, and had a more advanced pathologic state than NMGC.…”

Section: Mucins As Diagnostic Markers For Various Cancersmentioning

confidence: 99%

Current status of mucins in the diagnosis and therapy of cancer

et al. 2009

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Mucins are the most abundant high molecular weight glycoproteins in mucus. Their nature and glycosylation content dictates the biochemical and biophysical properties of viscoelastic secretions, pointing out an important role in diverse biological functions, such as differentiation, cell adhesions, immune responses, and cell signaling. Mucins are expressed in tubular organs by specialized epithelial cells in the body. Their aberrant expression is well documented in a variety of inflammatory or malignant diseases. From a prognosis point of view, their expression and alterations in glycosylation are associated with the development and progression of malignant diseases. Therefore, mucins can be used as valuable markers to distinguish between normal and disease conditions. Indeed, this alteration in glycosylation patterns generates several epitopes in the oligosaccharide side chains that can be used as diagnostic and/or prognostic markers. Furthermore, these characteristic tumor-associated epitopes are extensively used as appropriate immunotargets of malignant epithelial cells. Therefore, in an effort to detect and treat cancer at the earliest stage possible, mucins are analyzed as potential markers of disease for diagnosis, progression, and for therapeutic purposes. In this review, we focused on the current status of the distribution of mucins in normal and pathologic conditions and their clinical use both in cancer diagnosis and therapeutics treatments.

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“…A new H&E slide of each tumor was made and reviewed to determine the histological subtype according to Lauren`s classification (Choi et al, 2009).…”

Section: Samples and Tissue Collectionmentioning

confidence: 99%