2006
DOI: 10.1177/039463200601900315
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A Clinical Trial of Oral Hyposensitization in Systemic Allergy to Nickel

Abstract: Nickel allergy is the most common contact allergy. Some nickel-sensitive patients present systemic (cutaneous and/or digestive) symptoms related to the ingestion of high nickel-content foods, which significantly improve after a specific low nickel-content diet. The etiopathogenetic role of nickel in the genesis of systemic disorders is, furthermore, demonstrated by the relapse of previous contact lesions, appearance of widespread eczema and generalized urticaria-like lesions after oral nickel challenge test. T… Show more

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Cited by 36 publications
(32 citation statements)
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References 34 publications
(48 reference statements)
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“…The most common gastrointestinal symptoms include nausea, gastric pyrosis, meteorism, abdominal pain, diarrhea. This condition is known as Systemic Nickel Allergy Syndrome (SNAS) (1)(2). It has been demonstrated that Nickel assumption in SNAS patients is associated to an infiltrate of lymphocytes and plasma cells with edema and vasodilatation of the lamina propria at gastrointestinal mucosal level (2).…”
mentioning
confidence: 99%
“…The most common gastrointestinal symptoms include nausea, gastric pyrosis, meteorism, abdominal pain, diarrhea. This condition is known as Systemic Nickel Allergy Syndrome (SNAS) (1)(2). It has been demonstrated that Nickel assumption in SNAS patients is associated to an infiltrate of lymphocytes and plasma cells with edema and vasodilatation of the lamina propria at gastrointestinal mucosal level (2).…”
mentioning
confidence: 99%
“…The last definition, proposed by one of us (MDG), seems more adherent to the clinical picture of the disease. In a wide clinical survey performed in Italy on 1086 patients with Ni-contact allergy, 209 (19.2%) resulted affected not only by systemic cutaneous manifestations (urticaria, edema, eczema, erythema) but also by respiratory and digestive symptoms (nausea, gastric pyrosis, meteorism, abdominal pain, diarrhea and constipation) (13)(14)(15). Intestinal biopsies from SNAS patients show, compared to normal histological findings in ACD and healthy subjects, an inflammatory infiltrate of lymphocytes and plasma cells with edema and vasodilatation of the lamina propria (14), furthermore it has been detected an apoptotic decrease of epithelial CD8+ cells and an infiltration of CD4+ cells after an oral challenge with the metal (12).…”
mentioning
confidence: 99%
“…The trypcanocidal activity of L929 cells was dependent on endogenous nitric oxide synthase activity, which is largely induced by IFN-γ produced by NK cells. Moreover, studies in mice revealed an enhanced cytolytic activity of NK cells as early as 24 hours into T. cruzi infection (9)(10)(11)(12)(13)(14) and direct NK-mediated destruction of the extracellular epimastigote and trypomastigote forms of T. cruzi and T. lewisi in vitro (15)(16)(17).…”
Section: Nk Cells and Parasitesmentioning
confidence: 99%