A Clinical Trial of FK506 in Refractory Uveitis

Mycophenolate mofetil is a highly effective and safe immunosuppressive agent for the treatment of uveitis

“…However, up to a third of patients may fail on this regime [22], and CsA and prednisolone both bear a considerable long-term risk due to their toxic effects on protein and glucose metabolism and on the kidney [9]. Other immunomodulatory drugs such as tacrolimus [20] and azathioprine [17] have also been tried in patients with refractory uveitis, but their use is not widespread. Mycophenolic acid (MPA) is an immunosuppressive agent that was first used in the 1970s for the treatment of psoriasis [27].…”

Treatment of ocular cicatricial pemphigoid with tacrolimus (FK 506)

“…The efficacy and safety of FK 506 therapy has been demonstrated when used for prevention of solid organ transplant rejection [18,19] and in treatment of autoimmune diseases such as psoriasis [20], uveitis [21], type I diabetes mellitus [22], pediatric autoimmune enteropathy [23], and Crohn's disease [24]. FK 506 is an effective immunosuppressive agent which acts primarily on CD4+ T-helper lymphocytes by inhibiting the production of lymphokines, principally IL-2, at the transcriptional level.…”

Visual Prognosis in Patients with Behçet’s Disease Receiving Colchicine, Systemic Corticosteroid or Cyclosporin

“…FK. 506 has recently been reported to be effective in treating refractory uveitis, includ ing Behçef s disease [11], and a long-term study is needed.…”