A Clinical Study on Serum Prostaglandin E<sub>2</sub> with Low-Level Laser Therapy

Mizutani, Kazuhiro; Musya, Yoshiro; Wakae, Kouzaburou; Kobayashi, Toshiyuki; Tobe, Masahiro; Taira, Kazumasa; Harada, Takashi

doi:10.1089/pho.2004.22.537

Cited by 125 publications

(85 citation statements)

References 5 publications

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“…Durante o primeiro estágio, as pros taglandinas têm um importante papel no acúmulo de células infla matórias e os leucócitos podem exacerbar a lesão inicial; acredita-se que reduzindo a produção de PGE 2 e acúmulo de células inflamatórias, ocorrerá redução na lesão do tendão (6) . Assim, o laser de baixa potência mostra-se como uma ferramenta em potencial nesses casos, visto os efeitos de redução nos níveis de COX-2 (25) e PGE 2 (26) , além de redução do edema inflamatório por provável ação na liberação de hormônios adrenais (27) . Mas diferentemente dos antiinflamatórios não hormonais (6) , o laser poderia não apresentar atraso do reparo tendíneo, vista sua importante ação no aumento de fibras colágenas e na força tênsil final (12)(13)(14) .…”

Section: Discussionunclassified

Efeitos do laser de baixa potência sobre a dor e edema no trauma tendíneo de ratos

Bertolini

Silva

Ciena

et al. 2008

Rev Bras Med Esporte

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RESUMOA dor e o edema são sinais, entre outros, que ocorrem durante a fase inflamatória no processo de cura de tendões lesados. A terapia antiinflamatória farmacológica recebe algumas críticas, com relação a seus efeitos deletérios para o reparo. Dessa forma, ganha corpo o uso de recursos físicos para o controle do processo. O objetivo do presente estudo foi avaliar o uso do laser de baixa potência sobre a dor e edema em tendão calcâneo de ratos submetidos a trauma experimental. Foram utilizados 28 ratos Wistar, divididos em quatro grupos: GC -submetido à lesão traumática e ao tratamento placebo; G2 -submetido à lesão e irradiado com laser 2J/cm 2 ; G4 -submetido à lesão e irradiado com 4J/cm 2 ; G8 -submetido à lesão e irradiado com 8J/cm 2 . A lesão foi realizada com a queda de um peso sobre a face lateral do tendão calcâneo direito de cada animal, com energia de aproximadamente 0,40J. A dor foi avaliada pelo tempo de elevação da pata (TEP) do animal caminhando durante um minuto, sobre um cilindro metálico com 30cm de diâmetro em 3rpm; a avaliação do edema ocorreu através de paquimetria; os momentos de avaliação foram: pré-lesão, pós-lesão, pós-tratamento, duas horas, oito horas, 24 horas e 5º dia de lesão. O tratamento com laser 670nm ocorreu de forma pontual e diária. Os resultados mostraram aumentos do TEP e formação de edema em todos os grupos após a lesão; para os grupos tratados houve redução da dor e do edema, fato observado no grupo controle apenas com relação à diminuição de edema no 5º dia de placebo. Conclui-se que o tratamento com laser de baixa potência diminuiu dor e edema nos animais com trauma tendíneo, de forma dose-dependente. Palavras-chave:Tendão do calcâneo, Laser de baixa potência, avaliação da dor. ABSTRACTDuring the injured tendons healing process there is the inflammatory phase, which occurs in the presen ce, among other signs, of pain and edema. The antiinflammatory drug therapy receives some criticism, with respect to its deleterious effects for the repair, thus gain body the use of physical resources for the process control. The aim of this study was to evaluate the use of low level laser therapy on the pain and edema of the rats calcaneus tendon, subjected to experimental trauma. We used 28 rats Wistar, divided into four groups: GC -subjected to traumatic injury and the placebo treatment; G2 -subject to injury and irradiated with laser 2 J/cm 2 ; G4 -subject to injury and irradiated with 4 J/cm 2 ; G8 -submitted to injury and irradiated with 8 J/cm 2 . The lesion was performed with the fall of a weight on the side of the right calcaneus tendon of each animal, with energy of about 0.40 J. The pain was evaluated by the paw elevation time (PET) for a minute, the animal walking on a metal cylinder with 30 cm in diameter at 3 rpm; the edema evaluation occurred through caliper; moments of the evaluation were: after and before injury, before treatment, 2 hours, 8 hours, 24 hours and 5 th injury day. Treatment with laser 670 nm, was so punctual and daily. The results showed increases in PE...

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Section: Discussionunclassified

Efeitos do laser de baixa potência sobre a dor e edema no trauma tendíneo de ratos

Bertolini

Silva

Ciena

et al. 2008

Rev Bras Med Esporte

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“…• Inhibiting cyclooxygenase, interrupting conversion of arachidonic acid in to prostaglandins, especially prostaglandin E2 (PGE2) (Shimizu, Yamaguchi et al 1995;Mizutani, Musya et al 2004). …”

Section: Mechanisms Of Analgesic Effects Of Low Level Laser Therapymentioning

confidence: 99%

Non-Thermal, Non-Ablative CO2 Laser Therapy (NACLT): A New Approach to Relieve Pain in Some Painful Oral Diseases

Zand¹

2012

CO2 Laser - Optimisation and Application

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“…Il a été démontré que le laser diode de faible puissance à GaAs (904 nm) réduit de manière significative la migration cellulaire des polynucléaires neutrophiles dans un modèle expérimental de péritonite induit par les lipopolysaccharides bactériens [23]. Dans l'étude de Lim et al (2007) [24], l'irradiation par le laser 635 nm a permis de mettre en évidence une inhibition du relarguage des prostaglandines inflammatoires (PGE2) et des deux isoformes (1 et 2) de la cyclooxygénase [25]. Il a été démontré que les lasers de faible puissance avaient par ailleurs une action antalgique en augmentant la synthèse et le relarguage des endorphines, ainsi qu'en diminuant le relarguage de récepteurs nociceptifs comme la bradykinine et la sérotonine [26][27][28][29].…”

Section: Commentairesunclassified

Intérêt de la photothérapie au laser pour le traitement des mucites de la cavité buccale. Présentation d’un cas et revue de la littérature

Lescaille

Lang

Ernenwein

et al. 2010

Med Buccale Chir Buccale

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Mots clés : mucite buccale / laser / douleur / cancers des voies aéro-digestivesRésumé -La mucite est une complication classique de la radiothérapie et/ou de la chimiothérapie dans le traitement des cancers des voies aéro-digestives supérieures. Sa prise en charge est avant tout symptomatique : prescription d'un traitement antalgique, topique et systémique. Depuis quelques années, l'utilisation de différents lasers s'est révélée particulièrement intéressante pour le traitement préventif et curatif des mucites radio et/ou chimio-induites. L'objectif de cet article est de faire le point sur les mécanismes d'action du laser de basse énergie et ses indications dans le traitement de lésions muqueuses spécifiques. Nous rapportons ici l'exemple d'un cas de mucite de grade 3 radio-induite chez un patient en cours de radiothérapie postopératoire pour un carcinome épidermoïde du rebord maxillaire. La prise en charge classique (soins locaux et antalgiques) a été mise en place, en association avec des séances de laser Nd :YAP (1,34 μm). Le retour à une toxicité muqueuse ≤ 2 et une cicatrisation de la plupart des zones ulcérées ont été observés dès la première semaine d'application. Parallèlement, un effet antalgique rapide était constaté avec une diminution de la douleur qui est passée de 90 à 30 sur l'EVA.Key words: oral mucositis / laser / pain / head and neck cancers Abstract -Lasers in the treatment of oral mucositis. Report of a case and review of littérature. The mucositis is a common complication of radiotherapy and/or chemotherapy in the treatment of head and neck cancers. Its management is symptomatic with topical and systemic analgesics. In recent years, the use of various lasers has proved particularly interesting for the preventive and curative treatment of mucositis induced by radiotherapy and chemotherapy. The aim of this article is to review the mechanisms of action of low energy laser and its indications in the treatment of mucosal lesion. We report here the case of mucositis grade 3 radiation-induced in a patient during postoperative radiotherapy for squamous cell carcinoma of the maxillary. Classical treatment (local care and analgesics) was set up in conjunction with sessions of Nd:YAP (1.34 mm). The return to ≤ 2 mucosal toxicity and scarring of the ulcerated areas were most observed in the first week of application. Meanwhile a rapid analgesic effect was observed with a decrease in pain that went from 90-30 on the VAS.La radiothérapie, exclusive ou postopératoire, occupe une place fondamentale dans le traitement des cancers des voies aéro-digestives supérieures. Dans les formes avancées, le bé-néfice d'une chimiothérapie concomitante à l'irradiation a été clairement démontré : elle permet d'améliorer le contrôle local

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A Clinical Study on Serum Prostaglandin E₂ with Low-Level Laser Therapy

Abstract: Based on the above findings, the analgesic effects of LLLT were found to be valid. The serum PGE(2) levels are therefore considered to directly reflect nociceptive pain.

Cited by 125 publications

References 5 publications

Efeitos do laser de baixa potência sobre a dor e edema no trauma tendíneo de ratos

Efeitos do laser de baixa potência sobre a dor e edema no trauma tendíneo de ratos

Non-Thermal, Non-Ablative CO2 Laser Therapy (NACLT): A New Approach to Relieve Pain in Some Painful Oral Diseases

Intérêt de la photothérapie au laser pour le traitement des mucites de la cavité buccale. Présentation d’un cas et revue de la littérature

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A Clinical Study on Serum Prostaglandin E2 with Low-Level Laser Therapy

Abstract: Based on the above findings, the analgesic effects of LLLT were found to be valid. The serum PGE(2) levels are therefore considered to directly reflect nociceptive pain.

Cited by 125 publications

References 5 publications

Efeitos do laser de baixa potência sobre a dor e edema no trauma tendíneo de ratos

Efeitos do laser de baixa potência sobre a dor e edema no trauma tendíneo de ratos

Non-Thermal, Non-Ablative CO2 Laser Therapy (NACLT): A New Approach to Relieve Pain in Some Painful Oral Diseases

Intérêt de la photothérapie au laser pour le traitement des mucites de la cavité buccale. Présentation d’un cas et revue de la littérature

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A Clinical Study on Serum Prostaglandin E₂ with Low-Level Laser Therapy