A Clinical Study on Multiple Primary Cancers in Cases of Resected Lung Cancer

Sakaizawa, Takao; Katō, K.; Tominaga, Yoshiaki; Eguchi, Takashi; Kobayashi, N.; Hyogotani, Akira; Shiina, Takayuki; Yoshida, Kazuo; Amano, Jun

doi:10.2482/haigan.48.33

Cited by 12 publications

(2 citation statements)

References 11 publications

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“…There are some cases with quadruple primary malignancy involving lung cancer in literature [ 9 – 11 ]. However, this is the first case report of six primary cancers involving lung cancer.…”

Section: Discussionmentioning

confidence: 99%

Stereotactic body radiation therapy for multiple lung cancers in a patient with six primary cancers: a case report

Ishida,

Nagata,

Fukuda

et al. 2024

J Med Case Reports

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Background Surgery is the standard care for patients with early-stage lung cancer, and stereotactic body radiation therapy is an option for those who are medically inoperable or refuse surgery. Medical developments in diagnostic and therapeutic strategies would prolong prognosis of patients with cancer. The number of patients with multiple cancers has also increased. Duplex primary malignant neoplasms are the most common, and triple or more primary malignant neoplasms were extremely rare. This is the first case of sextuple primary malignant neoplasms with lung cancer. Case presentation We report a case of two courses of stereotactic body radiation therapy for an 88-year-old Japanese male patient with six primary cancers in five organs. Cancers were detected in the thyroid, prostate, esophagus, bladder, and lungs. He also had a history of angina pectoris and had undergone percutaneous coronary intervention. Although he was capable of undergoing surgery for lung cancers, he refused it because he had experienced many invasive treatments, such as surgeries and percutaneous coronary intervention. In January 2020, the first stereotactic body radiation therapy was performed for the adenocarcinoma in the right lung. In March 2022, the second stereotactic body radiation therapy was performed for the nodule of the left lung. Although he complained of mild dyspnea after the first stereotactic body radiation therapy, we did not use steroids because his peripheral oxygen saturation was within the normal range. He had pleural effusion, cardiac dilatation, and pericardial effusion 2 months after the second stereotactic body radiation therapy, which improved with the use of compression stockings. Conclusion A total of 43 and 17 months have passed since the first and second stereotactic body radiation therapy, respectively, there is no local recurrence and the patient can walk independently. We safely performed stereotactic body radiation therapy twice for our older patient with metachronous early-stage lung cancers. If another new tumor is detected, stereotactic body radiation therapy would be a good treatment option for the functional preservation of organs.

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Section: Discussionmentioning

confidence: 99%

Stereotactic body radiation therapy for multiple lung cancers in a patient with six primary cancers: a case report

Ishida,

Nagata,

Fukuda

et al. 2024

J Med Case Reports

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“…In our patient, we found the coexistence of adenocarcinoma in the right upper lobe S 3 of the lung and T-cell lymphoma. In a report by Kondo et al [5] on 731 cases of resected lung cancer, the frequency of multiple primary cancers, particularly with coexisting malignant lymphoma, was rare at 0.8%. In addition, only one case of T-cell lymphoma and primary lung cancer overlap has been reported [6].…”

Section: Discussionmentioning

confidence: 99%

Primary pulmonary T-cell lymphoma with lung adenocarcinoma: a case report

et al. 2019

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Background Primary pulmonary T-cell lymphoma is an extremely rare disease that is characterized by neoplastic proliferation of T-cell lymphocytes in the lung. Case presentation An 88-year-old Japanese woman was admitted to our hospital because of dyspnea. She was treated with antibiotics for chest x-ray findings of consolidation in the upper and middle lobes of the right lung. However, her condition worsened and progressed to respiratory failure, which led to death 14 days after admission. Autopsy of the lungs revealed both T-cell lymphoma and adenocarcinoma. Conclusions Our patient had a rare case of primary pulmonary T-cell lymphoma with primary lung adenocarcinoma. Further evidence and accumulation of case reports are required to clarify the pathophysiology of primary pulmonary T-cell lymphoma.

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