A clinical study of vitiligo in a rural set up of Gujarat

Abstract

Introduction:Vitiligo is an acquired depigmentary condition caused by inactivation or destruction of melanocytes in epidermis and hair follicle. Worldwide incidence of 1% has been reported; similar to various dermatological clinics in India. Widespread prejudice, ignorance, taboos, lack of scientific appraisal, and confusion of vitiligo with leprosy makes it an immense psychological stress.Aim:To know the clinical profile of vitiligo patient with associated cofactors.Materials and Methods:Total 1,010 patients of vitiligo attended in outpatient department at Shree Krishna Hospital (SKH) and Matar camp, Gujarat over 1 year period from August 2011 to July 2012 were included in this study. Detail history and clinical examination of patients were done.Results:Out of 1,010 patients 57.3% were females and 42.7 % were males. Most cases developed vitiligo by 2nd decade of life. Progressive course was found in 60.9 % of patients. Vitiligo vulgaris (57.8%) was most common morphological type. Most common site of onset (41.5%) and involvement (75.7%) was lower limb. Family history was present in 20.4%.Conclusions:Vitiligo constitutes important dermatological disease especially in India. The data suggest that local epidemiological behavior of vitiligo need not be the same across different regions. Vitiligo differs substantially in various clinical aspects.

A Practical Approach to the Diagnosis and Treatment of Vitiligo in Children

“…17 Children younger than 20 years represent 35.5% of patients in a Nigerian cohort 18 and age of onset before 20 years of age was noted in 47.8% of patients in a Gujarati cohort. 19 Mean age of onset can be as low as 6.9 years in Indian children 12 years and younger 17 and as high as 17.4 years in an unselected Saudi Arabian mixed pediatric and adult population. 20 Family history appears to be associated with earlier age of onset.…”

“…21 The prevalence of vitiligo by gender is usually close to if not equal, with some studies supporting female predilection in the youngest age groups. Vora et al 19 described a Gujarati cohort of 1100 patients of all ages in which 57.3% were female individuals and 42.7% were male individuals. In a cohort of 268 Indian children 12 years and younger, 56.7% were girls (n = 152) and 43.3% were boys (n = 116).…”

The effect of topical piperine combined with narrowband UVB on vitiligo treatment: A clinical trial study

“…Vitiligo is an acquired idiopathic disease that appears as skin depigmented patches (Vora, Patel, Chaudhary, Mehta, & Pilani, ). Its prevalence varies from 1% to 4% in different parts of the world and affects all races (Khaitan, Kathuria, & Ramam, ); moreover, it is more common among people with autoimmune diseases and children whose parents are suffering from this disease.…”

“…It could be concluded that the simultaneous use of NB-UVB and topical piperine has a remarkable effect on treatment of vitiligo. KEYWORDS herbal, pigmentation, piperine, topical treatment, UVB, vitiligo 1 | INTRODUCTION Vitiligo is an acquired idiopathic disease that appears as skin depigmented patches (Vora, Patel, Chaudhary, Mehta, & Pilani, 2014). Its prevalence varies from 1% to 4% in different parts of the world and affects all races (Khaitan, Kathuria, & Ramam, 2012); moreover, it is more common among people with autoimmune diseases and children whose parents are suffering from this disease.…”

Topical Histamine Stimulates Repigmentation of Nonsegmental Vitiligo by a Receptor-Dependent Mechanism

“…The prevalence of vitiligo exceeds 8% in certain regions of the world [reviewed in [1]]. Although the lesions are asymptomatic, vitiligo negatively impacts the quality of patients' lives [2,3].…”