A Clinical Study of the Effect of Dentifrice Containing Sodium Polyphosphate, Tranexamic Acid and Sodium Fluoride on the Prevention of Calculus Formation and Gingivitis.

Effects of topical application of inorganic polyphosphate on tissue remodeling in rat inflamed gingiva

“…Poly(P) is a safe material with very low toxicity, and it is used in food additives and cosmetics. A previous study reported that supplementation of poly(P) in dentifrices is effective to suppress the formation of supragingival dental calculus (31). The present study revealed that poly(P), at a concentration of > 1%, is also an effective agent that improves inflamed gingival connective tissue.…”

Effect of inorganic polyphosphate in periodontitis in the elderly

“…It could be hypothesised that periodontal inflammation is improved during a short-term period, and bone formation may be induced during prolonged use with Poly (P). However, Poly (P) has not been used for the treatment of periodontitis because its precise biological function in periodontal regeneration and its involvement in bone formation remain unknown, although the fact that Poly (P) is useful in the prevention of supragingival dental calculus has been demonstrated 33 . In the present study the effects and the utility of the local application of Poly (P), newly developed as a treatment for periodontitis, are analysed and discussed.…”