A Clinical Study of Surgical Management of Diaphyseal Fractures of Tibia With Intramedullary Interlocking Nail

Abstract

OBJECTIVE AND BACKGROUND: Turmeric (Curcuma longa) is one of the common constituents of our daily food. The present study was undertaken to evaluate the anti-diabetic effects of ethanolic extract of Rhizomes of curcuma longa in alloxan induced diabetic rats and compared with of Pioglitazone, which is the standard anti-diabetic agent. METHODS: Alloxan monohydrate is used to induce diabetes mellitus in albino rats in the dose of 120mg/kg i.p. and anti-diabetic activity of turmeric was studied by following study design. The rats are divided into 6 groups and each group contains 6 rats (N= 6) as follows. Group I: Normal control Given normal saline (10ml/kg/day). Group II: Diabetic control Given normal saline (10ml/kg/day). Group III: Euglycemic rats Given turmeric extract (300mg/kg/day). Group IV: Diabetic rats Given turmeric extract (300mg/kg/day). Group V: Diabetic control Given turmeric extract (500mg/kg/day). Group VI: Diabetic rats Given Pioglitazone (6mg/kg/day) Study was conducted for a period of 28 days and all the drugs were given orally once daily. Blood glucose levels were estimated at 1, 3, 5, 7 hrs. (acute study) and 7, 14, 21, 28 days (chronic study). The body weights of the rats in every groups recorded weekly and general behavior and health of the animal were monitored carefully. The data was analyzed statistically using student's paired and unpaired t-test. RESULTS: Ethanolic extract of turmeric produced significant ( p < 005 ) decreases in blood glucose levels on 7 th , 14 th , 21 th and 28 days in diabetic

Study of interlocking nail in shaft tibia fracture

“…In Rahul Katta [13] series also commonly males were affected accounting to 88 male (73.33%) compared to females of 32 patients (26.66 %). Radhakrishnan A.M. et al study [4] showed similar results (21 male 70% and 9 female patients 30%). Male predominance can be drawn from this inference.…”

“…In Rahul Katta study [13] , 88 patients had road traffic accident and 18 patients (15%) had fracture due to fall on floor/stairs. Radhakrishna A.M. et al study [4] , 26 patients (86.67%) had road traffic accident and 4 patients had fall from stairs. Increased incidence of road traffic accident for transportation has increased in recent times in our country and relatively the expansion of highway and security has not improved in relation with it.…”

“…In Yograj Rathwa et al [6] study, patient's average age was 27 years (age group 18 to 30) and most common age group was 17 to 44 years in Rahul Katta study [13] . In Radhakrishna A.M. et al study [4] , the most common age group was 18-39 years. From this it is infer that tibia shaft fractures occur in young and active patients.…”

“…In our study, majority of tibia shaft fracture were closed type (40 cases, 80%), followed by equal predominance of open grade I and open grade II injuries 5 cases (10%) each. In Yograj Rathwa et al study [6] , [4] 43% of cases were comminuted fractures while transverse fractures only made upto 23% cases. Oblique and transverse fractures made 30% fractures (09 patients).…”

“…In Yograj Rathwa et al study [6] , majority of the fractures occurred at distal third of tibia (32 cases, 64%) followed by middle third (11 cases, 22%) and proximal third of tibia (7 cases, 14%). In Rahul Katta study [13] , majority of the fractures occurred at middle third (62 cases, 52%) followed by distal third of tibia (41 cases, 34%) and proximal third of tibia (17 cases, 14%).In Radhakrishna A.M et al study [4] , majority of the fractures occurred at middle third shaft of tibia (18 cases,59.94%) followed by lower third fracture (7 cases, 23.31%) and proximal third of tibia shaft (5 cases, 16.65%). We had 19 patients (38%) who presented with distal 3rd tibia shaft fractures which are more prone to non-union because of poor vascularity in distal tibia region.…”