A Clinical Study in Hodgkin's Disease

Levinson, Bernard; Walter, Bruce A.; Wintrobe, M. M.; Cartwright, G. E.

doi:10.1001/archinte.1957.00260040019002

Cited by 36 publications

(6 citation statements)

References 23 publications

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“…Before the advent of chemotherapy pulmonary involvement was regarded as a late complication of Hodgkin's disease, giving a poor prognosis (Levinson et al, 1957). The survival rates without chemotherapy in the present study confirm this finding.…”

Section: Discussionsupporting

confidence: 87%

Lung involvement in Hodgkin's disease.

Macdonald¹

1977

Thorax

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Section: Discussionsupporting

confidence: 87%

Lung involvement in Hodgkin's disease.

Macdonald¹

1977

Thorax

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“…The mean haemoglobin concentration in patients with localized disease (Stages IA and 2A) was not significantly different from that of normal subjects but there was a significantly lower haemoglobin concentration in those with generalized disease. The incidence of anaemia is comparable to that found by Levinson et al (1957) (Hoffbrand, 1964). The extent to which haemolysis contributes to anaemia is difficult to assess.…”

Section: Discussionmentioning

confidence: 80%

Iron Metabolism in Hodgkin's Disease

Beamish¹,

Jones²,

Trevett³

et al. 1972

Br J Cancer

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An evaluation of iron metabolism has been carried out in 23 untreated patients with Hodgkin's disease and 6 patients with other lymphomata. The reduction in red cell life span is related to the stage of the disease. There is an almost universal impairment of iron release from the reticuloendothelial system with a consequent sideropenia and failure of iron delivery to the bone marrow for erythropoiesis. This defect is found in all stages of the disease and is not related to systemic symptoms.

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“…observed a significant difference between the presence or absence of these systemic symptoms. The prognostic value of pruritus has been debated, and many authors have concluded that it is without significance (Chawla et al, 1970;Levinson et al, 1957;Moore, 1963;and Musshoff and Boutis, 1968). of the three other symptoms, as reported by .…”

Section: Discussionmentioning

confidence: 98%

“…Westling (1965) also had thoroughly discussed the prognostic value of the laboratory indicators. Bethel1 et al (1950) and Levinson et al (1957) observed that nonanemic patients were shown to survive longer than anemic ones. Tubiana et al (1971) found that blood groups had no prognostic significance.…”

Section: Discussionmentioning

confidence: 98%

“…found to imply a particularly serious prognosis by some authors (Jeliffe and Thomson, 1955;Levinson et al, 1957), but Bethel1 et al (1950 found the 5-year survival rate of patients with this symptom to be lower than those of those without it. Peters (1971) also found that patients with mediastinal involvement had a better prognosis than patients with involvement of other lymph node regions.…”

Section: Discussionmentioning

confidence: 99%

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Prognostic factors in Hodgkin's disease

Say

Lee

Hori

et al. 1975

Journal of Surgical Oncology

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The clinical records and treatment results of 163 patients with Hodgkin's disease, who were seen at Ellis Fischel State Cancer Hospital (EFSCH) between 1940 and 1971, were reviewed and analyzed. More than 200 clinical and histological variables were recorded for each case of Hodgkin's disease, including details of radiotherapy and chemotherapy. Statistical studies were carried out in order to evaluate the independent prognosis significance of each of these factors. All of the lesions were reclassified according to the Lukes proposal which was modified and recommended at the 1965 Rye classification (except for hepatomegaly which was included in Stage IV). This is a retrospective study, and the modern techniques of staging were rarely used in pretreatment studies (since 1965, only ten patients have had an abdominal exploration). The basic work-up consisted of a complete blood count, urinalysis, blood type, chest X ray, and EKG. Lymphangiogram and radioisotope liver scans were used on less than 10% of the patients. About 30% of the patients had gastrointestinal X rays and 70% had IVP. Bone marrow biopsies -- the majority of which were done by needle aspiration -- were obtained for approximatley 50% of the patients. Clinical stage, histological type, and presence of absence of systemic symptoms appeared to be themost significant prognostic factors. The classification of systemic symptoms according to the criteria of either the Rye or Ann Arbor conferences showed no particular difference in determining the survival rate. Among the systemic symptoms, fever appeared to be the most important for survival rate. Survival rates were higher in nonanemic and nonlymphocytopenic patients. Eosinophilia, blood group, and Rh factor had no prognostic significance. The relapse-free interval was an important indicator of long-term prognosis. The unfavorable influence of relapse in ultimate prognosis was clearly seen; however, the extent of the relapse site was shown to have no significant influence on survival.

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A Clinical Study in Hodgkin's Disease

Cited by 36 publications

References 23 publications

Lung involvement in Hodgkin's disease.

Lung involvement in Hodgkin's disease.

Iron Metabolism in Hodgkin's Disease

Prognostic factors in Hodgkin's disease

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