Lung involvement in Hodgkin's disease.

Macdonald, J

doi:10.1136/thx.32.6.664

Cited by 63 publications

(12 citation statements)

References 8 publications

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“…[2][3][4][5][6] Fewer than 100 cases of PPHL have been reported in the literature, either as individual case reports or as small series. [2][3][4][5][6][7][8][9][10][11] Transthoracic fine needle aspiration cytology (FNAC) plays a crucial role in the diagnosis and management of patients with hematolymphoid malignancies, helping to avoid unnecessary excisions. PPHL needs to be distinguished from the commonly encountered neoplastic and nonneoplastic conditions of the lung.…”

mentioning

confidence: 96%

Primary pulmonary Hodgkin's lymphoma: A rare pitfall in transthoracic fine needle aspiration cytology

Kumar

Sidhu

Mistry

et al. 2008

Diagnostic Cytopathology

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Primary pulmonary Hodgkin's lymphoma (PPHL) is extremely rare. At an extranodal location such as the lung this lymphoma is likely to be confused with the more commonly occurring carcinomas at this site. We report the fine needle aspiration cytology (FNAC) findings of a PPHL in a 36-year-old male with a view to discuss the pitfalls and clues to the accurate cytologic diagnosis. This patient presented with a large, heterogeneously enhancing mass involving the anterior segment of right upper lobe without any evidence of nodal involvement. A CT-guided transthoracic FNAC of this mass revealed large connective tissue fragments with entrapped voluminous cells amidst a polymorphous population of eosinophils, polymorphs, and lymphocytes. The large cells showed abundant often stripped off cytoplasm, an irregular nucleus with nucleolus and were initially diagnosed as non-small cell carcinoma of the lung. In view of the locally advanced stage, patient received a carboplatin and gemcite-based chemotherapy with complete response but postchemotherapy patient refused local surgery. Two years later, the patient developed enlarged nodes which were diagnosed as Hodgkin's lymphoma, and a review of prior lung tumor confirmed the diagnosis of PPHL. Hence the rare diagnosis of PPHL should be kept in mind when a cytopathologist observes large cells embedded in collagenous tissue fragments with dominant cell dispersal amidst an inflammatory infiltrate in an aspirate from a primary lung tumor.

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confidence: 96%

Primary pulmonary Hodgkin's lymphoma: A rare pitfall in transthoracic fine needle aspiration cytology

Kumar

Sidhu

Mistry

et al. 2008

Diagnostic Cytopathology

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“…As bilateral pulmonary involvement or the pres ence of B symptoms is accompanied by a worse prog nosis, some authors [7] have advocated the same com binations of chemotherapy that are used for advanced Hodgkin's disease (stages 111 and IV). In a group of 9 patients with primary pulmonary involvement treated with a chemotherapy regimen of more than three agents, Yousem et al [3] reported that 6 patients were alive without evidence of disease after a median ob servation period of 3 years.…”

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confidence: 99%

Primary Pulmonary Manifestation of Hodgkin’s Disease

Schee

Dinkla²,

Knapen³

1990

Respiration

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We describe 2 patients with rare primary pulmonary manifestation of Hodgkin’s disease. Our 1st patient, who had unilateral pulmonary involvement and has been treated with segmental resection and cyclophosphamide, has survived > 18 years without relapse. He is the first patient reported with such a long survival. Our 2nd patient had bilateral pulmonary involvement and B symptoms and has been treated with an aggressive chemotherapy regimen. She is alive after 3 years without evidence of disease

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“…Irsfeld et al did not mention CT findings in their two patients with thoracic disease. In AT patients with HD, it might be difficult to interpret the basis for the pulmonary findings, especially when mediastinal involvement is apparent because primary pulmonary parencymal HD without lymph node involvement is exceedingly rare [5], and cavitation of the pulmonary lesions is even rarer [6]. Since data regarding the patterns of pulmonary involvement in patients with AT and HD are lacking, the development of cavitating pulmonary lesions in three of our six AT patients with HD raises the question of a possible common underlying pathophysiology in these patients.…”

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Letter to the editor: Ataxia telangiectasia and Hodgkin disease

Kutluk

Yalçın

Büyükpamukçu

2000

Med. Pediatr. Oncol.

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Pediatric Oncology [1]. We would like to share our experience with AT patients having HD.Between 1988 and 1998, we treated six children with AT and HD. Of these, five were females, the age at diagnosis of HD was 8 years in five patients and 6.5 in the other. The mean age in 210 Turkish children with HD treated in our center was 8 years, and 69% of the cases had mixed-cellularity [2]. The ages at diagnosis of HD in our AT patients are similar, and are in accordance with the two patients reported by Irsfeld et al. They noted that both their patients had mixed-cellularity HD [1], which also was found in 42% of the cases of AT reported by Mueller and Pizzo [3]. In contrast, the histologic subtypes in our six AT patients were as follows: four lymphocyte-depletion-type, one mixed-cellularity, and one unspecified.Respiratory infections are the principle cause for morbidity and mortality in AT patients. Ersoy et al. [4] reported that frequent sinopulmonary infections were the cause of death in two-thirds of patients who died in a series of 160 AT patients from our hospital. Another interesting finding in our patients was that plain chest X-ray films displayed evidence of mediastinal disease in five cases, three of them having accompanying cavitating pulmonary infiltrates. Thoracic computed tomography (CT) was available for these three patients in whom cavitations and pulmonary infiltrates were clearly demonstrated. Irsfeld et al. did not mention CT findings in their two patients with thoracic disease. In AT patients with HD, it might be difficult to interpret the basis for the pulmonary findings, especially when mediastinal involvement is apparent because primary pulmonary parencymal HD without lymph node involvement is exceedingly rare [5], and cavitation of the pulmonary lesions is even rarer [6]. Since data regarding the patterns of pulmonary involvement in patients with AT and HD are lacking, the development of cavitating pulmonary lesions in three of our six AT patients with HD raises the question of a possible common underlying pathophysiology in these patients.

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Lung involvement in Hodgkin's disease.

Cited by 63 publications

References 8 publications

Primary pulmonary Hodgkin's lymphoma: A rare pitfall in transthoracic fine needle aspiration cytology

Primary pulmonary Hodgkin's lymphoma: A rare pitfall in transthoracic fine needle aspiration cytology

Primary Pulmonary Manifestation of Hodgkin’s Disease

Letter to the editor: Ataxia telangiectasia and Hodgkin disease

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