A clinical risk prediction model of orthodontic-induced external apical root resorption

IRAK1 variant is protective for orthodontic‐induced external apical root resorption

“…In complex phenotypes, like EARR, the identification of risk factors is an important step for the implementation of the so‐called medicine of precision. In the present study, using a multiple linear regression model, we identified a new susceptibility gene, IRAK1 , and confirmed the role of four clinical variables, gender, treatment duration, Hyrax appliance, and premolar extractions (Pereira et al , ,b). The model explains about 30% (determination coefficient = 0.285) of the %EARRmax variability.…”

An Insight into Risk Factors for Root Resorption During Orthodontic Treatment

“…It is found that almost all patients and up to 91% of all teeth showed some degree of root shortening but few patients and teeth had root shortening 7 of >4 mm. Pereira et al 8 reported percentage in external apical root resorption varies on each anterior teeth ranging from 8.5% for upper right canines, to 12.6% for upper right lateral incisors, with significant higher root resorption in incisors than canines. Makedonas et al 5 reported 4% of patients were diagnosed with root resorption after 6 months of fixed appliances with only 3.1% of maxillary incisors involved.…”

“…Evaluating root resorption through radiograph is more related to clinical practise and many researchers had favored 3D images such as cone beam CT and micro-CT in detecting root resorption during orthodontic treatment as compared to 2D images such as periapical, panoramic and lateral cephalometric [5][6][7][8]10,18,[21][22][23][24][25][26][27][28][29][30] . Higher prevalence of root resorption is expected in 3D images as the view eliminates overlapping structure and allow for better visualization of specific tissue…”

“…Host factors: Gender differences in the risk of root resorption were investigated and male was found to have a higher chance of root resorption as compared to women 8,11 . Nevertheless, there were studies that proved that there was insignificant difference in gender in relation to root resorption 7,10,13,18,21,38 .…”

“…Nevertheless, there were studies that proved that there was insignificant difference in gender in relation to root resorption 7,10,13,18,21,38 . As far as age concern, patients above 20 years old may have significant relation to root resorption but most of the studies found age is not a risk factor for root resorption 8,11,18,21,38 .…”